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Atmospheric Pressure plAsma meets biomaterials for bone Cancer HEaling

Total Cost €


EC-Contrib. €






Project "APACHE" data sheet

The following table provides information about the project.


Organization address
postcode: 8034

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Project website
 Total cost 1˙499˙887 €
 EC max contribution 1˙499˙887 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-STG
 Funding Scheme ERC-STG
 Starting year 2017
 Duration (year-month-day) from 2017-04-01   to  2022-03-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

Cold atmospheric pressure plasmas (APP) have been reported to selectively kill cancer cells without damaging the surrounding tissues. Studies have been conducted on a variety of cancer types but to the best of our knowledge not on any kind of bone cancer. Treatment options for bone cancer include surgery, chemotherapy, etc. and may involve the use of bone grafting biomaterials to replace the surgically removed bone. APACHE brings a totally different and ground-breaking approach in the design of a novel therapy for bone cancer by taking advantage of the active species generated by APP in combination with biomaterials to deliver the active species locally in the diseased site. The feasibility of this approach is rooted in the evidence that the cellular effects of APP appear to strongly involve the suite of reactive species created by plasmas, which can be derived from a) direct treatment of the malignant cells by APP or b) indirect treatment of the liquid media by APP which is then put in contact with the cancer cells. In APACHE we aim to investigate the fundamentals involved in the lethal effects of cold plasmas on bone cancer cells, and to develop improved bone cancer therapies. To achieve this we will take advantage of the highly reactive species generated by APP in the liquid media, which we will use in an incremental strategy: i) to investigate the effects of APP treated liquid on bone cancer cells, ii) to evaluate the potential of combining APP treated liquid in a hydrogel vehicle with/wo CaP biomaterials and iii) to ascertain the potential three directional interactions between APP reactive species in liquid medium with biomaterials and with chemotherapeutic drugs. The methodological approach will involve an interdisciplinary team, dealing with plasma diagnostics in gas and liquid media; with cell biology and the effects of APP treated with bone tumor cells and its combination with biomaterials and/or with anticancer drugs.


year authors and title journal last update
List of publications.
2019 Juan Tornin, Miguel Mateu-Sanz, Aida Rodríguez, Cédric Labay, Rene Rodríguez, Cristina Canal
Pyruvate Plays a Main Role in the Antitumoral Selectivity of Cold Atmospheric Plasma in Osteosarcoma
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-019-47128-1
Scientific Reports 9/1 2019-11-22
2018 Cédric Labay, Inés Hamouda, Maria-Pau Ginebra, Cristina Canal
Modification of hydrogel-based biomaterials by atmospheric pressure plasma to enhance tissue regeneration
published pages: 4, ISSN: , DOI:
7th International Conference on Plasma Medicine (ICPM7) Book of abstracts 1 2019-05-06
2017 Canal Barnils, Cristina; Humbert, Marjolaine; Guillem Martí, Jordi; Ginebra Molins, Maria Pau
Plasma jet selectivity on bone cancer cells and liquid-mediated effects
published pages: 34, ISSN: , DOI:
nternational Workshop on Plasma for Cancer Treatment Book of Abstracts 1 2019-05-06
2018 Cristina Canal, Juan Tornín, Miguel Mateu, Inés Hamouda, Cédric Labay, Jordi Guillem, Maria-Pau Ginebra
Influence of the composition of plasma-activated medium on osteosarcoma
published pages: , ISSN: , DOI:
International Conference on Plasma Medicine (ICPM7) Book of abstracts 7 2019-05-06
2017 Canal Barnils, Cristina; Hamouda, Ines; Guillem Martí, Jordi; Ginebra Molins, Maria Pau
Liquid-mediated effects of cold plasma on bone cancer
published pages: 68, ISSN: , DOI:
\"Book of abstracts - International Symposium on Plasma Nanoscience and Nanotechnology. \"\"iPlasmaNano-VIII 2017\"\"\" 1 2019-05-06
2018 Inés Hamouda, Alix Gouhier, Cédric Labay, Maria-Pau Ginebra, Cristina Canal
Generation Of Reactive Species By Plasma Needle In Different Liquids
published pages: 34-35, ISSN: 2212-8166, DOI: 10.1016/j.cpme.2017.12.054
Clinical Plasma Medicine 9 2019-05-06
2018 Anna Khlyustova, Cédric Labay, Zdenko Machala, Maria-Pau Ginebra, Cristina Canal
Important parameters in plasma jets for the production of RONS in liquids for plasma medicine: a brief review
published pages: ACCEPTED, SOON I, ISSN: 2095-0179, DOI:
Frontiers of Chemical Science and Engineering 2019-04-18
2017 Cristina Canal, Raul Fontelo, Ines Hamouda, Jordi Guillem-Marti, Uros Cvelbar, Maria-Pau Ginebra
Plasma-induced selectivity in bone cancer cells death
published pages: 72-80, ISSN: 0891-5849, DOI: 10.1016/j.freeradbiomed.2017.05.023
Free Radical Biology and Medicine 110 2019-04-03

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