NanoPD SIGNED
Single Molecule Nanoscale Sensors for Improved Therapies and Diagnostics
Total Cost €
0EC-Contrib. €
0Partnership
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Explore the words cloud of the NanoPD project. It provides you a very rough idea of what is the project "NanoPD" about.
Project "NanoPD" data sheet
The following table provides information about the project.
| Coordinator |
IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
Organization address contact info |
| Coordinator Country | United Kingdom [UK] |
| Total cost | 1˙997˙680 € |
| EC max contribution | 1˙997˙680 € (100%) |
| Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
| Code Call | ERC-2016-COG |
| Funding Scheme | ERC-COG |
| Starting year | 2017 |
| Duration (year-month-day) | from 2017-10-01 to 2022-09-30 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE | UK (LONDON) | coordinator | 1˙997˙680.00 |
Map
Project objective
One of the most significant challenges facing the healthcare community is the accurate and selective detection and quantification of trace levels of analyte. This can have enormous impact with numerous application, especially in the context of biosensing, where applications can range from early stage detection of disease to the identification of new markers amongst others. These challenges are compounded when the analysis of real samples or even complex mixtures are required. To address this need, single molecule or near single molecule methods are currently being heavily pursued which allows for the discrimination of events with low copy numbers by removing the “clouding” associated with ensemble averaging. Although strategies for detecting single molecules have existed for a number of years, efficient and cost-effective label-free methods without the need for chemical modification are lacking especially when considering smaller molecules directly in unprocessed clinical samples. As part of this proposal, I intend to address this limitation by developing new strategies in single molecule nanoscale sensing which will be both highly sensitive and selective for improved therapeutics and diagnostics applications.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2019 |
Ye Ma, Debabrata Sikdar, Aleksandra Fedosyuk, Leonora Velleman, Daniel J. Klemme, Sang-Hyun Oh, Anthony R. J. Kucernak, Alexei A. Kornyshev, Joshua B. Edel Electrotunable Nanoplasmonics for Amplified Surface Enhanced Raman Spectroscopy published pages: , ISSN: 1936-0851, DOI: 10.1021/acsnano.9b05257 |
ACS Nano | 2020-01-30 |
| 2019 |
Shenglin Cai, Jasmine Y. Y. Sze, Aleksandar P. Ivanov, Joshua B. Edel Small molecule electro-optical binding assay using nanopores published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-019-09476-4 |
Nature Communications 10/1 | 2020-01-30 |
| 2019 |
Yanjun Zhang, Yasufumi Takahashi, Sung Pil Hong, Fengjie Liu, Joanna Bednarska, Philip S. Goff, Pavel Novak, Andrew Shevchuk, Sahana Gopal, Iros Barozzi, Luca Magnani, Hideki Sakai, Yoshimoto Suguru, Takuto Fujii, Alexander Erofeev, Peter Gorelkin, Alexander Majouga, Dominik J. Weiss, Christopher Edwards, Aleksandar P. Ivanov, David Klenerman, Elena V. Sviderskaya, Joshua B. Edel, Yuri Korchev High-resolution label-free 3D mapping of extracellular pH of single living cells published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-019-13535-1 |
Nature Communications 10/1 | 2020-01-30 |
| 2019 |
Markéta Kubánková, Xiaoyan Lin, Tim Albrecht, Joshua B. Edel, Marina K. Kuimova Rapid Fragmentation during Seeded Lysozyme Aggregation Revealed at the Single Molecule Level published pages: , ISSN: 0003-2700, DOI: 10.1021/acs.analchem.9b01221 |
Analytical Chemistry | 2020-01-30 |
| 2019 |
Ye Ma, Debabrata Sikdar, Aleksandra Fedosyuk, Leonora Velleman, Minggang Zhao, Longhua Tang, Alexei A. Kornyshev, Joshua B. Edel Auxetic Thermoresponsive Nanoplasmonic Optical Switch published pages: 22754-22760, ISSN: 1944-8244, DOI: 10.1021/acsami.9b05530 |
ACS Applied Materials & Interfaces 11/25 | 2020-01-30 |
| 2017 |
L. Velleman, L. Scarabelli, D. Sikdar, A. A. Kornyshev, L. M. Liz-Marzán, J. B. Edel Monitoring plasmon coupling and SERS enhancement through in situ nanoparticle spacing modulation published pages: 67-83, ISSN: 1359-6640, DOI: 10.1039/c7fd00162b |
Faraday Discussions 205 | 2019-06-11 |
| 2017 |
Paolo Cadinu, Binoy Paulose Nadappuram, Dominic J. Lee, Jasmine Y. Y. Sze, Giulia Campolo, Yanjun Zhang, Andrew Shevchuk, Sylvain Ladame, Tim Albrecht, Yuri Korchev, Aleksandar P. Ivanov, Joshua B. Edel Single Molecule Trapping and Sensing Using Dual Nanopores Separated by a Zeptoliter Nanobridge published pages: 6376-6384, ISSN: 1530-6984, DOI: 10.1021/acs.nanolett.7b03196 |
Nano Letters 17/10 | 2019-06-11 |
| 2017 |
Jasmine Y. Y. Sze, Aleksandar P. Ivanov, Anthony E. G. Cass, Joshua B. Edel Single molecule multiplexed nanopore protein screening in human serum using aptamer modified DNA carriers published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-017-01584-3 |
Nature Communications 8/1 | 2019-06-11 |
| 2018 |
Liang Xue, Paolo Cadinu, Binoy Paulose Nadappuram, Minkyung Kang, Ye Ma, Yuri Korchev, Aleksandar P. Ivanov, Joshua B. Edel Gated Single-Molecule Transport in Double-Barreled Nanopores published pages: 38621-38629, ISSN: 1944-8244, DOI: 10.1021/acsami.8b13721 |
ACS Applied Materials & Interfaces 10/44 | 2019-06-11 |
| 2018 |
Hayley Weir, Joshua B. Edel, Alexei A. Kornyshev, Debabrata Sikdar Towards Electrotuneable Nanoplasmonic Fabry–Perot Interferometer published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-017-19011-4 |
Scientific Reports 8/1 | 2019-06-11 |
| 2017 |
Avijit Barik, Yao Zhang, Roberto Grassi, Binoy Paulose Nadappuram, Joshua B. Edel, Tony Low, Steven J. Koester, Sang-Hyun Oh Graphene-edge dielectrophoretic tweezers for trapping of biomolecules published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-017-01635-9 |
Nature Communications 8/1 | 2019-06-11 |
| 2018 |
Paolo Cadinu, Giulia Campolo, Sergii Pud, Wayne Yang, Joshua B. Edel, Cees Dekker, Aleksandar P. Ivanov Double Barrel Nanopores as a New Tool for Controlling Single-Molecule Transport published pages: 2738-2745, ISSN: 1530-6984, DOI: 10.1021/acs.nanolett.8b00860 |
Nano Letters 18/4 | 2019-06-11 |
| 2017 |
Ren Ren, Yanjun Zhang, Binoy Paulose Nadappuram, Bernice Akpinar, David Klenerman, Aleksandar P. Ivanov, Joshua B. Edel, Yuri Korchev Nanopore extended field-effect transistor for selective single-molecule biosensing published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-017-00549-w |
Nature Communications 8/1 | 2019-06-11 |
| 2019 |
Binoy Paulose Nadappuram, Paolo Cadinu, Avijit Barik, Alexander J. Ainscough, Michael J. Devine, Minkyung Kang, Jorge Gonzalez-Garcia, Josef T. Kittler, Keith R. Willison, Ramon Vilar, Paolo Actis, Beata Wojciak-Stothard, Sang-Hyun Oh, Aleksandar P. Ivanov, Joshua B. Edel Nanoscale tweezers for single-cell biopsies published pages: 80-88, ISSN: 1748-3387, DOI: 10.1038/s41565-018-0315-8 |
Nature Nanotechnology 14/1 | 2019-06-11 |
| 2018 |
Ye Ma, Cristian Zagar, Daniel J. Klemme, Debabrata Sikdar, Leonora Velleman, Yunuen Montelongo, Sang-Hyun Oh, Anthony R. Kucernak, Joshua B. Edel, Alexei A. Kornyshev A Tunable Nanoplasmonic Mirror at an Electrochemical Interface published pages: 4604-4616, ISSN: 2330-4022, DOI: 10.1021/acsphotonics.8b01105 |
ACS Photonics 5/11 | 2019-06-11 |
| 2018 |
Dana Al Sulaiman, Paolo Cadinu, Aleksandar P. Ivanov, Joshua B. Edel, Sylvain Ladame Chemically Modified Hydrogel-Filled Nanopores: A Tunable Platform for Single-Molecule Sensing published pages: 6084-6093, ISSN: 1530-6984, DOI: 10.1021/acs.nanolett.8b03111 |
Nano Letters 18/9 | 2019-06-11 |
| 2018 |
Viktoria Rakers, Paolo Cadinu, Joshua B. Edel, Ramon Vilar Development of microfluidic platforms for the synthesis of metal complexes and evaluation of their DNA affinity using online FRET melting assays published pages: 3459-3469, ISSN: 2041-6520, DOI: 10.1039/c8sc00528a |
Chemical Science 9/14 | 2019-06-11 |
| 2017 |
William J. Peveler, Sacha Noimark, Hassan Al-Azawi, Gi Byoung Hwang, Colin R. Crick, Elaine Allan, Joshua B. Edel, Aleksandar P. Ivanov, Alexander J. MacRobert, Ivan P. Parkin Covalently Attached Antimicrobial Surfaces Using BODIPY: Improving Efficiency and Effectiveness published pages: 98-104, ISSN: 1944-8244, DOI: 10.1021/acsami.7b13273 |
ACS Applied Materials & Interfaces 10/1 | 2019-06-11 |
| 2018 |
Aleksandar P. Ivanov, Joshua B. Edel Scissoring genes with light published pages: 800-801, ISSN: 1755-4330, DOI: 10.1038/s41557-018-0116-6 |
Nature Chemistry 10/8 | 2019-06-11 |
| 2017 |
Yunuen Montelongo, Debabrata Sikdar, Ye Ma, Alastair J. S. McIntosh, Leonora Velleman, Anthony R. Kucernak, Joshua B. Edel, Alexei A. Kornyshev Electrotunable nanoplasmonic liquid mirror published pages: 1127-1135, ISSN: 1476-1122, DOI: 10.1038/nmat4969 |
Nature Materials 16/11 | 2019-06-11 |
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