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PlasmoCycle SIGNED

DNA dynamics in the unusual cell cycle of the malaria parasite Plasmodium falciparum

Total Cost €

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EC-Contrib. €

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Partnership

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 PlasmoCycle project word cloud

Explore the words cloud of the PlasmoCycle project. It provides you a very rough idea of what is the project "PlasmoCycle" about.

temporal    drugs    environment    little    antimalarial    transmitting    fibres    genome    synthesis    male    parasite    inside    transform    asynchronous    transmission    wealth    generates    exposure    cytokinesis    labelling    unusual    nuclei    gametes    mosquito    subject    characterisation    independent    biology    contrasting    human    permit    resolution    rounds    replicative    molecule    first    dynamics    replicates    previously    copied    unprecedented    10mins    checkpoints    interventions    dna    drug    elucidate    plasmodium    basic    model    changing    occurs    diverging    virulence    erythrocytes    host    nascent    gametocyte    prior    necessitating    remarkably    mapping    extraordinarily    schizogony    cell    spacing    single    protozoan    rapid    replication    resistance    malaria    biological    inform    vital    origin    cycle    extremely    infected    speed    despite    spatio    cells    gametogenesis    sexual    sequences    investigation    blocking    promises    lifecycle    cycles    24hrs    reveal   

Project "PlasmoCycle" data sheet

The following table provides information about the project.

Coordinator
THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE 

Organization address
address: TRINITY LANE THE OLD SCHOOLS
city: CAMBRIDGE
postcode: CB2 1TN
website: www.cam.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website https://www.path.cam.ac.uk/directory/catherine-merrick/
 Total cost 1˙998˙696 €
 EC max contribution 1˙998˙696 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-COG
 Funding Scheme ERC-COG
 Starting year 2017
 Duration (year-month-day) from 2017-06-01   to  2022-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE UK (CAMBRIDGE) coordinator 1˙801˙331.00
2    UNIVERSITY OF KEELE UK (KEELE) participant 197˙364.00

Map

 Project objective

This proposal promises to transform our understanding of the basic biology of the malaria parasite Plasmodium, and of how that biology affects virulence. Remarkably little is known about the Plasmodium cell cycle, despite a wealth of knowledge on the subject in model cells. This project will reveal, with unprecedented resolution, how DNA replication is organised in Plasmodium and how changing conditions in the human host and exposure to antimalarial drugs affect it.

Plasmodium is an early-diverging protozoan with a complex lifecycle & unusual cell-biological features. It replicates in its human host by ‘schizogony’: a single parasite generates many nuclei via independent, asynchronous rounds of genome replication prior to cytokinesis. This occurs over ~24hrs inside infected erythrocytes. However, the genome can also be copied extremely rapidly during the sexual cycle in the malaria-transmitting mosquito. Here 8 male gametes are produced from a single gametocyte in less than 10mins, necessitating extraordinarily rapid DNA synthesis.

This project will first elucidate the spatio-temporal dynamics of DNA replication in these contrasting cell cycles. To do this, I have developed a method for labelling nascent DNA replication, which was not previously possible in Plasmodium. It will permit: a) a detailed characterisation, at the whole-cell level, of the asynchronous genome replication that occurs in schizogony; b) a study of replication origin spacing & DNA synthesis speed at single-molecule resolution on DNA fibres, comparing these parameters in schizogony & gametogenesis; c) mapping sequences with replication origin activity in the Plasmodium genome; d) investigation of cell-cycle checkpoints & replicative responses to the changing environment in the human host and to antimalarial drugs. These are crucial issues for understanding parasite virulence and drug-resistance, and the work will inform vital new research into transmission-blocking interventions for malaria.

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The information about "PLASMOCYCLE" are provided by the European Opendata Portal: CORDIS opendata.

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