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PlasmoCycle SIGNED

DNA dynamics in the unusual cell cycle of the malaria parasite Plasmodium falciparum

Total Cost €

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EC-Contrib. €

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Partnership

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 PlasmoCycle project word cloud

Explore the words cloud of the PlasmoCycle project. It provides you a very rough idea of what is the project "PlasmoCycle" about.

sexual    temporal    gametocyte    dna    dynamics    promises    characterisation    gametogenesis    checkpoints    mosquito    model    reveal    molecule    gametes    interventions    biological    permit    virulence    genome    transmission    antimalarial    blocking    nuclei    protozoan    prior    copied    spacing    inside    malaria    despite    unprecedented    little    unusual    drug    transmitting    wealth    extremely    previously    independent    investigation    origin    resolution    generates    environment    synthesis    plasmodium    inform    necessitating    biology    host    single    spatio    cells    occurs    subject    remarkably    cycle    mapping    extraordinarily    basic    nascent    diverging    lifecycle    labelling    cycles    rounds    fibres    10mins    resistance    contrasting    drugs    schizogony    asynchronous    cytokinesis    erythrocytes    parasite    cell    replicative    changing    replication    rapid    exposure    male    first    replicates    transform    24hrs    infected    sequences    human    speed    vital    elucidate   

Project "PlasmoCycle" data sheet

The following table provides information about the project.

Coordinator
THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE 

Organization address
address: TRINITY LANE THE OLD SCHOOLS
city: CAMBRIDGE
postcode: CB2 1TN
website: www.cam.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website https://www.path.cam.ac.uk/directory/catherine-merrick/
 Total cost 1˙998˙696 €
 EC max contribution 1˙998˙696 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-COG
 Funding Scheme ERC-COG
 Starting year 2017
 Duration (year-month-day) from 2017-06-01   to  2022-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE UK (CAMBRIDGE) coordinator 1˙801˙331.00
2    UNIVERSITY OF KEELE UK (KEELE) participant 197˙364.00

Map

 Project objective

This proposal promises to transform our understanding of the basic biology of the malaria parasite Plasmodium, and of how that biology affects virulence. Remarkably little is known about the Plasmodium cell cycle, despite a wealth of knowledge on the subject in model cells. This project will reveal, with unprecedented resolution, how DNA replication is organised in Plasmodium and how changing conditions in the human host and exposure to antimalarial drugs affect it.

Plasmodium is an early-diverging protozoan with a complex lifecycle & unusual cell-biological features. It replicates in its human host by ‘schizogony’: a single parasite generates many nuclei via independent, asynchronous rounds of genome replication prior to cytokinesis. This occurs over ~24hrs inside infected erythrocytes. However, the genome can also be copied extremely rapidly during the sexual cycle in the malaria-transmitting mosquito. Here 8 male gametes are produced from a single gametocyte in less than 10mins, necessitating extraordinarily rapid DNA synthesis.

This project will first elucidate the spatio-temporal dynamics of DNA replication in these contrasting cell cycles. To do this, I have developed a method for labelling nascent DNA replication, which was not previously possible in Plasmodium. It will permit: a) a detailed characterisation, at the whole-cell level, of the asynchronous genome replication that occurs in schizogony; b) a study of replication origin spacing & DNA synthesis speed at single-molecule resolution on DNA fibres, comparing these parameters in schizogony & gametogenesis; c) mapping sequences with replication origin activity in the Plasmodium genome; d) investigation of cell-cycle checkpoints & replicative responses to the changing environment in the human host and to antimalarial drugs. These are crucial issues for understanding parasite virulence and drug-resistance, and the work will inform vital new research into transmission-blocking interventions for malaria.

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The information about "PLASMOCYCLE" are provided by the European Opendata Portal: CORDIS opendata.

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