Opendata, web and dolomites

PlasmoCycle SIGNED

DNA dynamics in the unusual cell cycle of the malaria parasite Plasmodium falciparum

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 PlasmoCycle project word cloud

Explore the words cloud of the PlasmoCycle project. It provides you a very rough idea of what is the project "PlasmoCycle" about.

basic    independent    characterisation    vital    single    copied    labelling    fibres    gametocyte    despite    reveal    interventions    nuclei    resolution    rapid    subject    lifecycle    replication    previously    spatio    gametogenesis    resistance    remarkably    drug    erythrocytes    mapping    cells    elucidate    biology    first    occurs    24hrs    molecule    malaria    transmission    sequences    cell    mosquito    cycle    generates    extraordinarily    transmitting    promises    protozoan    investigation    model    gametes    male    dna    origin    transform    exposure    10mins    diverging    drugs    cycles    blocking    cytokinesis    extremely    environment    wealth    antimalarial    little    biological    permit    spacing    contrasting    parasite    prior    inside    plasmodium    unusual    schizogony    temporal    nascent    host    virulence    dynamics    replicative    genome    necessitating    infected    human    replicates    unprecedented    rounds    inform    checkpoints    speed    sexual    changing    synthesis    asynchronous   

Project "PlasmoCycle" data sheet

The following table provides information about the project.

Coordinator
THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE 

Organization address
address: TRINITY LANE THE OLD SCHOOLS
city: CAMBRIDGE
postcode: CB2 1TN
website: www.cam.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website https://www.path.cam.ac.uk/directory/catherine-merrick/
 Total cost 1˙998˙696 €
 EC max contribution 1˙998˙696 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-COG
 Funding Scheme ERC-COG
 Starting year 2017
 Duration (year-month-day) from 2017-06-01   to  2022-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE UK (CAMBRIDGE) coordinator 1˙801˙331.00
2    UNIVERSITY OF KEELE UK (KEELE) participant 197˙364.00

Map

 Project objective

This proposal promises to transform our understanding of the basic biology of the malaria parasite Plasmodium, and of how that biology affects virulence. Remarkably little is known about the Plasmodium cell cycle, despite a wealth of knowledge on the subject in model cells. This project will reveal, with unprecedented resolution, how DNA replication is organised in Plasmodium and how changing conditions in the human host and exposure to antimalarial drugs affect it.

Plasmodium is an early-diverging protozoan with a complex lifecycle & unusual cell-biological features. It replicates in its human host by ‘schizogony’: a single parasite generates many nuclei via independent, asynchronous rounds of genome replication prior to cytokinesis. This occurs over ~24hrs inside infected erythrocytes. However, the genome can also be copied extremely rapidly during the sexual cycle in the malaria-transmitting mosquito. Here 8 male gametes are produced from a single gametocyte in less than 10mins, necessitating extraordinarily rapid DNA synthesis.

This project will first elucidate the spatio-temporal dynamics of DNA replication in these contrasting cell cycles. To do this, I have developed a method for labelling nascent DNA replication, which was not previously possible in Plasmodium. It will permit: a) a detailed characterisation, at the whole-cell level, of the asynchronous genome replication that occurs in schizogony; b) a study of replication origin spacing & DNA synthesis speed at single-molecule resolution on DNA fibres, comparing these parameters in schizogony & gametogenesis; c) mapping sequences with replication origin activity in the Plasmodium genome; d) investigation of cell-cycle checkpoints & replicative responses to the changing environment in the human host and to antimalarial drugs. These are crucial issues for understanding parasite virulence and drug-resistance, and the work will inform vital new research into transmission-blocking interventions for malaria.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "PLASMOCYCLE" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "PLASMOCYCLE" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

Resonances (2019)

Resonances and Zeta Functions in Smooth Ergodic Theory and Geometry

Read More  

Aware (2019)

Aiding Antibiotic Development with Deep Analysis of Resistance Evolution

Read More  

FunDiT (2019)

Functional Diversity of T cells

Read More