Opendata, web and dolomites
  1. home
  2. trasparenza
  3. open h2020
  4. plasmocycle

PlasmoCycle SIGNED

DNA dynamics in the unusual cell cycle of the malaria parasite Plasmodium falciparum

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0
 Outcomes and results

 PlasmoCycle project word cloud

Explore the words cloud of the PlasmoCycle project. It provides you a very rough idea of what is the project "PlasmoCycle" about.

temporal    rapid    speed    replication    cytokinesis    cycles    parasite    replicates    gametogenesis    cell    blocking    erythrocytes    nascent    cycle    sexual    mosquito    lifecycle    characterisation    human    remarkably    contrasting    mapping    fibres    checkpoints    previously    host    exposure    malaria    sequences    extremely    unprecedented    dna    vital    resolution    permit    wealth    elucidate    origin    changing    infected    10mins    spatio    dynamics    inform    schizogony    basic    environment    promises    subject    24hrs    virulence    nuclei    investigation    spacing    generates    single    gametes    biology    prior    male    first    model    extraordinarily    labelling    occurs    unusual    transform    drugs    despite    transmission    genome    molecule    reveal    biological    little    plasmodium    replicative    antimalarial    copied    necessitating    resistance    drug    diverging    interventions    cells    independent    rounds    inside    gametocyte    protozoan    asynchronous    synthesis    transmitting   

Project "PlasmoCycle" data sheet

The following table provides information about the project.

Coordinator		 THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE 

Organization address
address: TRINITY LANE THE OLD SCHOOLS
city: CAMBRIDGE
postcode: CB2 1TN
website: www.cam.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country United Kingdom [UK]
 Project website https://www.path.cam.ac.uk/directory/catherine-merrick/
 Total cost 1˙998˙696 €
 EC max contribution 1˙998˙696 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-COG
 Funding Scheme ERC-COG
 Starting year 2017
 Duration (year-month-day) from 2017-06-01   to  2022-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE UK (CAMBRIDGE) coordinator 1˙801˙331.00
2    UNIVERSITY OF KEELE UK (KEELE) participant 197˙364.00

Map

 Project objective

This proposal promises to transform our understanding of the basic biology of the malaria parasite Plasmodium, and of how that biology affects virulence. Remarkably little is known about the Plasmodium cell cycle, despite a wealth of knowledge on the subject in model cells. This project will reveal, with unprecedented resolution, how DNA replication is organised in Plasmodium and how changing conditions in the human host and exposure to antimalarial drugs affect it.

Plasmodium is an early-diverging protozoan with a complex lifecycle & unusual cell-biological features. It replicates in its human host by ‘schizogony’: a single parasite generates many nuclei via independent, asynchronous rounds of genome replication prior to cytokinesis. This occurs over ~24hrs inside infected erythrocytes. However, the genome can also be copied extremely rapidly during the sexual cycle in the malaria-transmitting mosquito. Here 8 male gametes are produced from a single gametocyte in less than 10mins, necessitating extraordinarily rapid DNA synthesis.

This project will first elucidate the spatio-temporal dynamics of DNA replication in these contrasting cell cycles. To do this, I have developed a method for labelling nascent DNA replication, which was not previously possible in Plasmodium. It will permit: a) a detailed characterisation, at the whole-cell level, of the asynchronous genome replication that occurs in schizogony; b) a study of replication origin spacing & DNA synthesis speed at single-molecule resolution on DNA fibres, comparing these parameters in schizogony & gametogenesis; c) mapping sequences with replication origin activity in the Plasmodium genome; d) investigation of cell-cycle checkpoints & replicative responses to the changing environment in the human host and to antimalarial drugs. These are crucial issues for understanding parasite virulence and drug-resistance, and the work will inform vital new research into transmission-blocking interventions for malaria.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "PLASMOCYCLE" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "PLASMOCYCLE" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

evolSingleCellGRN (2019)

Constraint, Adaptation, and Heterogeneity: Genomic and single-cell approaches to understanding the evolution of developmental gene regulatory networks

Read More  

IMMUNOTHROMBOSIS (2019)

Cross-talk between platelets and immunity - implications for host homeostasis and defense

Read More  

VictPart (2019)

Righting Victim Participation in Transitional Justice

Read More