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STARFISH DNA

Stalling the Replication Fork via the Impedimental Stabilization of Higher-order DNAs

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

STARFISH DNA project word cloud

Explore the words cloud of the STARFISH DNA project. It provides you a very rough idea of what is the project "STARFISH DNA" about.

anticancer junction unusual downstream replication series signaling either emerged opens covalent molecules irreversible starfish create stress spread upstream damages uncontrolled fight trigger disrupt replicative molecule combination standalone impedimental group cells proliferating breaks alternative cancers agent stalling stabilization dna drugs strand abnormal clinic fold therapeutic cancer small structures manner junctions diseases induce synergistic fork compounds dnas

Project "STARFISH DNA" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITE DIJON BOURGOGNE Organization address address: ESPLANADE ERASME MAISON DE L UNIVERSITE city: DIJON CEDEX postcode: 21078 website: www.u-bourgogne.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	France [FR]
Project website	https://sites.google.com/site/monchaudchembiolab/starfish-dna
Total cost	185˙076 €
EC max contribution	185˙076 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2016
Funding Scheme	MSCA-IF-EF-ST
Starting year	2017
Duration (year-month-day)	from 2017-10-01 to 2019-09-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITE DIJON BOURGOGNE UNIVERSITE DIJON BOURGOGNE Organization address address: ESPLANADE ERASME MAISON DE L UNIVERSITE city: DIJON CEDEX postcode: 21078 website: www.u-bourgogne.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (DIJON CEDEX)	coordinator	185˙076.00

Map

Project objective

'Cancer is a generic term for a group of diseases characterized by the uncontrolled growth and spread of cells with abnormal proliferating activity. Most of the anticancer drugs currently used in the clinic trigger irreversible DNA damages and thus, promote replicative stress. As an alternative of irreversible DNA strand breaks, the non-covalent small-molecule stabilization of unusual, non-B DNA structures has emerged as a promising way to create DNA damages. One of such non B-DNA structures is a three-way DNA junction that might fold both upstream and downstream of the replication fork. The stabilization of three-way junctions by small molecules therefore opens a promising way to induce replicative stress in a highly cancer-specific manner. The main goal of the project 'STARFISH DNA' (for 'Stalling the Replication Fork via the Impedimental Stabilization of Higher-order DNAs') is to identify a new series of compounds capable of creating DNA damages through three-way junction stabilization and to use them either as standalone therapeutic agent to fight against cancers or in combination with established drugs that disrupt cancer signaling pathways in a synergistic manner.'

Publications

List of publications.
year	authors and title	journal	last update
2019	Pauline Lejault, Katerina Duskova, Claire Bernhard, Ibai E. Valverde, Anthony Romieu, David Monchaud The Scope of Application of Macrocyclic Polyamines Beyond Metal Chelation published pages: 6146-6157, ISSN: 1434-193X, DOI: 10.1002/ejoc.201900870	European Journal of Organic Chemistry 2019/36	2020-03-23
2019	Katerina Duskova, JÃ©rÃ©my Lamarche, Souheila Amor, Coralie Caron, Nicolas Queyriaux, Marie Gaschard, Marie-JosÃ© Penouilh, Guillaume de Robillard, Dominique Delmas, Charles H. Devillers, Anton Granzhan, Marie-Paule Teulade-Fichou, Murielle Chavarot-Kerlidou, Bruno Therrien, SÃ©bastien Britton, David Monchaud Identification of Three-Way DNA Junction Ligands through Screening of Chemical Libraries and Validation by Complementary in Vitro Assays published pages: 4456-4466, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.8b01978	Journal of Medicinal Chemistry 62/9	2020-03-23
2017	Ludivine Guyon, Marc Pirrotta, Katerina Duskova, Anton Granzhan, Marie-Paule Teulade-Fichou, David Monchaud TWJ-Screen: an isothermal screening assay to assess ligand/DNA junction interactions in vitro published pages: , ISSN: 0305-1048, DOI: 10.1093/nar/gkx1118	Nucleic Acids Research	2020-03-23

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The information about "STARFISH DNA" are provided by the European Opendata Portal: CORDIS opendata.