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EvoCellFate SIGNED

Evolution of cell fate decision during development

Total Cost €

EC-Contrib. €

Partnership

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EvoCellFate project word cloud

Explore the words cloud of the EvoCellFate project. It provides you a very rough idea of what is the project "EvoCellFate" about.

genera combination variation homologous elegans trajectories nematode precursor genetically cellular intraspecific first nematodes genus mechanisms cells molecular mutagenesis group structured modern termed building oscheius acquire vulva faster definition collaborators inter constrains obtain cell skills six framework progressively worldwide theory genome genetics unknown underlying species network techniques tractable biased quantitative contrast caenorhabditis mechanistic lineages developmentally background me evolutionary p4 developmental successful sequencing evolve scales editing shows evolution population fates biasing probe p3 genetic largely p8 named integrate basis constrained sister adoption random bioinformatic fate

Project "EvoCellFate" data sheet

The following table provides information about the project.

Coordinator	CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS Organization address address: RUE MICHEL ANGE 3 city: PARIS postcode: 75794 website: www.cnrs.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	France [FR]
Total cost	185˙076 €
EC max contribution	185˙076 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2016
Funding Scheme	MSCA-IF-EF-ST
Starting year	2017
Duration (year-month-day)	from 2017-11-01 to 2019-10-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS Organization address address: RUE MICHEL ANGE 3 city: PARIS postcode: 75794 website: www.cnrs.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	coordinator	185˙076.00

Map

Project objective

'During development cells progressively acquire specific features that result in the definition of cellular fates.Inter- and intra-specific homologous cell lineages show significant variation in the adoption of particular cell fates. Yet, at present the genetic and molecular mechanisms underlying these intra-specific changes in cell fate and how variation in cell fates is biased during evolutionary trajectories are largely unknown. In this project I will use the vulva system in genetically tractable nematodes to i)identify the molecular basis of intraspecific cell fate variation and ii)to investigate whether evolutionary trajectories in cell fate variation are developmentally constrained in distinct nematode genera. In Caenorhabditis species, among the six 'vulva precursor cells', only one termed P3.p shows fate evolution within and among species.In contrast,in Oscheius species(sister genus)other vulva precursor cells fates evolve faster, named P4.p and P8.p. The work is structured into two main objectives. First,I will investigate the molecular and genetic basis of intraspecific P3.p cell fate variation in C.elegans using quantitative genetics, whole-genome sequencing and modern genome editing techniques. Second,I will probe the role of developmental constrains in biasing evolutionary trends of cell fate variation by using a combination of random mutagenesis and quantitative genetics.This project will contribute to integrate the field of evolution of development with a population and quantitative genetic framework and will provide a mechanistic genetic understanding of cell fate variation during development and evolution at several evolutionary scales. Based on a highly successful research group in a worldwide-recognized institute and its network of collaborators,it will allow me to obtain a strong background in evolutionary theory,nematode development,genome bioinformatic skills and quantitative genetics,building on my strong molecular and developmental background'

Publications

List of publications.
year	authors and title	journal	last update
2019	Fabrice Besnard, Joao Picao-Osorio, Clement Dubois, Marie-Anne Felix A broad mutational target explains an evolutionary trend published pages: , ISSN: , DOI: 10.1101/2019.12.18.881250	bioRxiv	2020-01-28

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The information about "EVOCELLFATE" are provided by the European Opendata Portal: CORDIS opendata.