Explore the words cloud of the EvoCellFate project. It provides you a very rough idea of what is the project "EvoCellFate" about.
The following table provides information about the project.
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
|Coordinator Country||France [FR]|
|Total cost||185˙076 €|
|EC max contribution||185˙076 € (100%)|
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
|Duration (year-month-day)||from 2017-11-01 to 2019-10-31|
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|1||CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS||FR (PARIS)||coordinator||185˙076.00|
'During development cells progressively acquire specific features that result in the definition of cellular fates.Inter- and intra-specific homologous cell lineages show significant variation in the adoption of particular cell fates. Yet, at present the genetic and molecular mechanisms underlying these intra-specific changes in cell fate and how variation in cell fates is biased during evolutionary trajectories are largely unknown. In this project I will use the vulva system in genetically tractable nematodes to i)identify the molecular basis of intraspecific cell fate variation and ii)to investigate whether evolutionary trajectories in cell fate variation are developmentally constrained in distinct nematode genera. In Caenorhabditis species, among the six 'vulva precursor cells', only one termed P3.p shows fate evolution within and among species.In contrast,in Oscheius species(sister genus)other vulva precursor cells fates evolve faster, named P4.p and P8.p. The work is structured into two main objectives. First,I will investigate the molecular and genetic basis of intraspecific P3.p cell fate variation in C.elegans using quantitative genetics, whole-genome sequencing and modern genome editing techniques. Second,I will probe the role of developmental constrains in biasing evolutionary trends of cell fate variation by using a combination of random mutagenesis and quantitative genetics.This project will contribute to integrate the field of evolution of development with a population and quantitative genetic framework and will provide a mechanistic genetic understanding of cell fate variation during development and evolution at several evolutionary scales. Based on a highly successful research group in a worldwide-recognized institute and its network of collaborators,it will allow me to obtain a strong background in evolutionary theory,nematode development,genome bioinformatic skills and quantitative genetics,building on my strong molecular and developmental background'
|year||authors and title||journal||last update|
Fabrice Besnard, Joao Picao-Osorio, Clement Dubois, Marie-Anne Felix
A broad mutational target explains an evolutionary trend
published pages: , ISSN: , DOI: 10.1101/2019.12.18.881250
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The information about "EVOCELLFATE" are provided by the European Opendata Portal: CORDIS opendata.
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