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GENSURGE SIGNED

Designer recombinases for efficient and safe genome surgery

Total Cost €

EC-Contrib. €

Partnership

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GENSURGE project word cloud

Explore the words cloud of the GENSURGE project. It provides you a very rough idea of what is the project "GENSURGE" about.

flexible repair abundance initiated human insertions replace mutations resealing inducing recent intrinsic therapeutic innovative shortcoming recombinases engineer indels vivo ssr deletions endogenous strategies site locus introduce nucleotide cleavage animal editing introduction compendium double evolution flawless universal surgery genomic binding processed malfunctioning unprecedented resolution substrate straightforward correct possess correction ssrs gensurge breaks origin cell demonstrated precise defect repaired specificity cells platform linked fulfill dna breakthroughs subsequently molecular efficient recognize genome regenerate strategy safe inversions directed integrate customizing gene genuine strand cure ideally understand plant vitro sequence corrections opportunity first technologies successful

Project "GENSURGE" data sheet

The following table provides information about the project.

Coordinator	TECHNISCHE UNIVERSITAET DRESDEN Organization address address: HELMHOLTZSTRASSE 10 city: DRESDEN postcode: 1069 website: http://www.tu-dresden.de/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Germany [DE]
Total cost	2˙380˙425 €
EC max contribution	2˙380˙425 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2016-ADG
Funding Scheme	ERC-ADG
Starting year	2018
Duration (year-month-day)	from 2018-01-01 to 2022-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	TECHNISCHE UNIVERSITAET DRESDEN TECHNISCHE UNIVERSITAET DRESDEN Organization address address: HELMHOLTZSTRASSE 10 city: DRESDEN postcode: 1069 website: http://www.tu-dresden.de/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (DRESDEN)	coordinator	2˙380˙425.00

Map

Project objective

Recent breakthroughs in the field of genome editing provide a genuine opportunity to establish innovative approaches to repair DNA mutations to replace, engineer or regenerate malfunctioning cells in vitro or in vivo. However, most of the recently developed technologies introduce double-strand DNA breaks at a target locus as the first step to gene correction. These breaks are subsequently repaired by one of the cell intrinsic DNA repair pathways, typically inducing an abundance of insertions and deletions (indels). Ideally, for many applications genome editing should, however, be efficient and specific, without the introduction of indels. Site-specific recombinases (SSRs) allow precise genome editing without triggering endogenous DNA repair pathways and possess the unique ability to fulfill both cleavage and immediate resealing of the processed DNA in vivo. However, customizing the DNA binding specificity of SSRs is not straightforward. With this project, we propose to solve this shortcoming. We have already demonstrated that by applying substrate-linked directed evolution, SSRs can be generated that specifically recognize therapeutic targets. The objective of this project is the development of a universal genome editing platform that allows flexible, efficient and safe gene corrections in cells of any origin without triggering cell intrinsic DNA repair. GenSurge aims to: i) sequence an unprecedented, comprehensive compendium of evolved SSRs to understand the directed molecular evolution process at nucleotide resolution; ii) integrate the knowledge obtained in i) to develop a unique SSR-based approach to correct genomic inversions; iii) develop a universal SSR-based strategy that allows flawless, precise and safe genome editing to correct any gene defect in human, animal or plant cells. The successful implementation of this project will deliver a comprehensive, safe and efficient platform from which genome surgery-based cure strategies can be initiated.

Publications

List of publications.
year	authors and title	journal	last update
2018	Madina Karimova, Oliver Baker, Aylin Camgoz, Ronald Naumann, Frank Buchholz, Konstantinos Anastassiadis A single reporter mouse line for Vika, Flp, Dre, and Cre-recombination published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-32802-7	Scientific Reports 8/1	2019-09-04

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