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u-PBeam SIGNED

Microdosimetry study of a new radiation therapy method based on proton minibeams

Total Cost €

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EC-Contrib. €

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Partnership

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Project "u-PBeam" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Project website https://www.researchgate.net/profile/C_Guardiola
 Total cost 173˙076 €
 EC max contribution 173˙076 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2017
 Duration (year-month-day) from 2017-10-01   to  2019-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 173˙076.00

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 Project objective

Radiotherapy (RT) is the medical use of ionising radiation to treat cancer. The main challenge is to deposit a high enough (curative) dose in the tumor while risk organs near the tumour remain at tolerable doses. About 52% of cancer patients receive RT at least once during treatment. The RT has achieved great success in the cure or palliation of various cancers, but for improving this statistic, new treatment modalities as proton radiotherapy (PT) are rapidly expanding. PT achieves very high dose conformity around the target, allowing a better protection of the organs at risk (decreasing radiation side effect). However, using PT the dose delivered to a tumour is still conditioned by the dose that can be tolerated by the surrounding normal tissues. This is particularly critical for certain types of radioresistant tumours, such as hypoxic tumors, for those localized near organs at risk or sensitive structures (e.g. the spinal cord), and paediatrics cancers. For these types of cancers with poor prognosis it is imperative to find new RT approaches that reduce the normal tissue complication probability (NTCP). A recent novel therapy aim to increase the effective dose therapies by using a distinct dose delivery method based on proton minibeams (pMBRT). To implement this promising technique at clinical centers, microdosimetric data are required on the radiation quality aspects of proton minibeams to take advantage of their enhanced relative biological effectiveness versus conventional radiotherapy sources. Currently there are only one array of microdosimeters, as the proposed herein, capable of measuring these parameters in proton therapy. This is the challenge where a candidate approach is preferred.

 Publications

year authors and title journal last update
List of publications.
2019 Guardiola C., De Marzi L., Prezado Y.
Verification of Monte Carlo dose calculation engine in proton minibeam radiotherapy ina passive scattering beamline for preclinical trials
published pages: , ISSN: 0007-1285, DOI:
The British Journal of Radiology 2020-04-09
2020 J Prieto-Pena, F Gómez; C. Guardiola, Anna Baratto-Roldán, M. C. Jiménez-Ramos, J. García López, M Baselga, J Pardo-Montero and C. Fleta
On the limitations of microdosimetry based inmicrostructured solid state devices
published pages: , ISSN: 1361-6560, DOI:
Physics in Medicine and Biology 2020-04-09
2019 Bertolet A., Grilj V., Guardiola C., Harken A.D., Cortés-Giraldo M.A., Baratto-Roldán A., Carabe A.
Microdosimetric distributions for low energy protons with silicon-based 3D detectors and 1 Geant4-DNA simulations
published pages: , ISSN: 2473-4209, DOI:
Medical Physics 2020-04-09
2018 Consuelo Guardiola, Yolanda Prezado, Christophe Roulin, Judith W.J. Bergs
Effect of X-ray minibeam radiation therapy on clonogenic survival of glioma cells
published pages: 7-13, ISSN: 2405-6308, DOI: 10.1016/j.ctro.2018.07.005
Clinical and Translational Radiation Oncology 13 2020-04-09

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