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HybridRetina SIGNED

Hybrid Retinal Prosthesis: High-Resolution Electrode Array Integrated with Neurons for Restoration of Sight

Total Cost €

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EC-Contrib. €

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Project "HybridRetina" data sheet

The following table provides information about the project.

Coordinator
BAR ILAN UNIVERSITY 

Organization address
address: BAR ILAN UNIVERSITY CAMPUS
city: RAMAT GAN
postcode: 52900
website: www.biu.ac.il

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Israel [IL]
 Total cost 1˙499˙582 €
 EC max contribution 1˙499˙582 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-STG
 Funding Scheme ERC-STG
 Starting year 2018
 Duration (year-month-day) from 2018-05-01   to  2023-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    BAR ILAN UNIVERSITY IL (RAMAT GAN) coordinator 1˙499˙582.00

Map

 Project objective

Vision restoration in patients with outer retinal degenerative diseases, such as Age-related Macular Degeneration and Retinitis Pigmentosa can be achieved by bypassing the degenerated photoreceptors and the electrical stimulation of the relatively well-preserved inner retina through electrode implants. Although current retinal prostheses have been shown to provide useful vision in blind patients, the obtained visual acuity and quality are still relatively low. Several challenges cannot be addressed with the current retinal prosthetic technologies. First, increasing the electrode density for achieving high visual acuity is limited by the distance between the electrodes and the target neurons. Second, electrical stimulation by the current technologies is not selective for specific retinal circuitry (e.g. ON and OFF pathways). Finally, retinal neurons are stimulated by pulsed rather than in a continuously graded potential fashion, which provides the photoreceptors with an unrivalled dynamic range and sensitivity in natural vision. Here we propose a paradigm shift toward sight restoration with a hybrid retinal prosthesis aimed at overcoming the aforementioned limitations. The hybrid implant is composed of a very high density electrode array (pixel distance of 15µm) coupled with neurons to create a tight neuron-electrode coupling. Following implantation of the hybrid prosthesis, the neurons integrate and synapse with the host retinal circuits. Upon patterned electrical stimulation of the neurons by the electrodes, the host bipolar cells are activated while preserving the natural vision circuits. The ultimate electrode-neurons proximity allows for the significant increase in pixel density, the low charge neural activation, and the continuous graded potential activation. This research can advance our knowledge in the retinal field and in other neural prosthetics and if successful, it will enable future vision restoration with unprecedented resolution.

 Publications

year authors and title journal last update
List of publications.
2020 Tamar Arens-Arad, Nairouz Farah, Rivkah Lender, Avital Moshkovitz, Thomas Flores, Daniel Palanker, Yossi Mandel
Cortical Interactions between Prosthetic and Natural Vision
published pages: 176-182.e2, ISSN: 0960-9822, DOI: 10.1016/j.cub.2019.11.028
Current Biology 30/1 2020-02-05
2019 Itai Henn, Ayelet Atkins, Amos Markus, Gal Shpun, Hannah‐Noa Barad, Nairouz Farah, Yossi Mandel
SEM/FIB Imaging for Studying Neural Interfaces
published pages: , ISSN: 1932-846X, DOI: 10.1002/dneu.22707
Developmental Neurobiology 2020-02-05
2019 Adi Gross, Nadav H. Ivzan, Nairouz Farah, Yossi Mandel
High-resolution VSDI retinotopic mapping via a DLP-based projection system
published pages: 5117, ISSN: 2156-7085, DOI: 10.1364/boe.10.005117
Biomedical Optics Express 10/10 2020-02-05

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The information about "HYBRIDRETINA" are provided by the European Opendata Portal: CORDIS opendata.

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