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ZEBRAONCOFISH SIGNED

Zebrafish avatar as a real-time in vivo platform for personalized cancer therapeutics

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

ZEBRAONCOFISH project word cloud

Explore the words cloud of the ZEBRAONCOFISH project. It provides you a very rough idea of what is the project "ZEBRAONCOFISH" about.

decisions remarkable samples interventions company chance leader therapeutic metabolic created presented subjacent tumor differently zebrafish interspecies makeup close thanks approx cancer team cancerous performed morbidity understand transplant cell tax complete commercialization influence market mean biotechnological estimations solutions mechanism extensive treatment anticancer acquired found solution personalized opportunity 35 xenotransplantation 425 platform million avatars living guide effect onset difficulty vivo people tailor time therapy healthcare profile drugs biology treatments patient display hospitals carry actionable ultimate deaths zebraoncofish biological made human assays individual disease dynamic roadmap progression genetic underlying tubes lines lab mortality directed complexity

Project "ZEBRAONCOFISH" data sheet

The following table provides information about the project.

Coordinator	IKAN BIOTECH S.L. Organization address address: CALLE CHAPITELA 20 1 city: PAMPLONA postcode: 31001 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Spain [ES]
Project website	http://zebraoncofish.com/
Total cost	2˙004˙583 €
EC max contribution	2˙004˙583 € (100%)
Programme	1. H2020-EU.3.1.3. (Treating and managing disease)
Code Call	H2020-SMEINST-2-2016-2017
Funding Scheme	SME-2
Starting year	2017
Duration (year-month-day)	from 2017-09-01 to 2020-05-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	IKAN BIOTECH S.L. IKAN BIOTECH S.L. Organization address address: CALLE CHAPITELA 20 1 city: PAMPLONA postcode: 31001 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (PAMPLONA)	coordinator	2˙004˙583.00

Map

Project objective

The Zebrafish Lab is a biotechnological company leader in the development and commercialization of novel, tailor-made solutions based on in vivo zebrafish assays. Thanks to the extensive knowledge acquired by the R&D projects performed in the field by our team for many years and a close collaboration with Hospitals and Cancer Research Institutions, we have identified a remarkable opportunity in the ZEBRAONCOFISH project that will mean a 5-year after tax-R.O.I of 425% according to our estimations. The ultimate goal of the project presented as ZEBRAONCOFISH is to complete the technical roadmap required to bring to the healthcare market a novel real time in vivo platform for personalized cancer treatment based on the use of zebrafish “avatars” as personalized, living test tubes. Cancer is a leading cause of morbidity and mortality with approx. 35 million people affected by this disease and more than 8 million deaths per year. A major difficulty found in effective cancer treatment is the complexity of the biological mechanism underlying cancer onset and disease progression. This is because the genetic makeup and metabolic profile of each individual patient influence the effect of anticancer drugs. As such, different people respond differently to the same therapy. The solution we propose in the ZEBRAONCOFISH project is the use of zebrafish avatars as an in vivo platform to guide therapeutic decisions in actionable cancer patient-directed interventions. These avatars will be created by xenotransplantation (interspecies transplant) of human cancer cell lines/ tumor samples in zebrafish. The chance to carry out a dynamic display of the cancerous process in vivo will offer the unique opportunity to understand the subjacent cancer biology and design tailor-made treatments for each patient.

Deliverables

List of deliverables.
ZEBRAONCOFISH webpage	Websites, patent fillings, videos etc.	2020-04-24 04:18:30

Take a look to the deliverables list in detail: detailed list of ZEBRAONCOFISH deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2018	Letrado P, de Miguel I, Lamberto I, DÃez-MartÃnez R, Oyarzabal J. Zebrafish: Speeding up the Cancer Drug Discovery Process. published pages: , ISSN: 0008-5472, DOI:	Cancer Research	2020-04-24

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