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AMPHORA SIGNED

ACOUSTIC MARKERS FOR ENHANCED REMOTE SENSING OF RADIATION DOSES

Total Cost €

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EC-Contrib. €

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Partnership

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Project "AMPHORA" data sheet

The following table provides information about the project.

Coordinator
KATHOLIEKE UNIVERSITEIT LEUVEN 

Organization address
address: OUDE MARKT 13
city: LEUVEN
postcode: 3000
website: www.kuleuven.be

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Belgium [BE]
 Project website http://www.amphora-project.eu
 Total cost 3˙932˙775 €
 EC max contribution 3˙932˙775 € (100%)
 Programme 1. H2020-EU.1.2.1. (FET Open)
 Code Call H2020-FETOPEN-1-2016-2017
 Funding Scheme RIA
 Starting year 2017
 Duration (year-month-day) from 2017-11-01   to  2021-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KATHOLIEKE UNIVERSITEIT LEUVEN BE (LEUVEN) coordinator 1˙563˙750.00
2    FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V. DE (MUNCHEN) participant 679˙878.00
3    UNIVERSITA DEGLI STUDI DI ROMA TOR VERGATA IT (ROMA) participant 475˙000.00
4    ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM NL (ROTTERDAM) participant 443˙750.00
5    INTERUNIVERSITAIR MICRO-ELECTRONICA CENTRUM BE (LEUVEN) participant 393˙521.00
6    DOSEVUE BE (Diepenbeek) participant 376˙875.00

Map

 Project objective

Approximately 50% of all cancer patients receive radiation therapy as part of their treatment. The aim is hereby to maximise tumor irradiation and to minimize healthy tissue irradiation. This implies a need for appropriate dosimetry strategies that can effectively measure the actual radiation dose imparted on the tumor. However, state-of-the-art dosimetry cannot quantify the dose distribution in (and around) the tumor, hereby inhibiting the full potential of radiotherapy. AMFORA aims to develop a non-invasive in-situ dosimetry system for radiation therapy with the potential of on-line dose assessment by casting ultrasound contrast agents (UCAs) into dose sensing theranostic devices. UCAs will be upgraded to injectable dose-sensitive and targeted devices that gather in tumor tissue and translate imparted radiation dosage into a modulation of their acoustic response upon ultrasound interrogation. Tailored ultrasound imaging and advanced signal processing algorithms will be developed to extract the (change in) acoustic signature of UCAs from backscatter data and to translate this information into a 2D or 3D dose distribution map. The specific objectives of this project are the design, development and pre-clinical validation of the aforementioned UCA based dosimetry system and a customised ultrasound read-out technology. Upon successful completion, AMFORA will have enabled the assessment of the effective radiation dose distribution in (and around) the tumor, offering an advanced and objective means to compare and evaluate treatment efficacy of different radiotherapy modalities. Such novel technology would revolutionize quality assurance and treatment follow up in radiotherapy, which also unmistakably will lead to increased patient safety and improved treatment protocols. Moreover, AMFORA is expected to trigger an avalanche of novel technologies for radiation therapy delivery and to pave the way for other in-vivo UCA based distributed sensing applications.

 Deliverables

List of deliverables.
Project Opening Event Other 2019-05-31 10:19:33
review meeting documents meeting 1 Documents, reports 2019-05-31 10:19:27
Data Management Plan Open Research Data Pilot 2019-05-31 10:19:34
Website & project logo Websites, patent fillings, videos etc. 2019-05-31 10:19:32
Intermediate report on backscatter modeling Documents, reports 2019-05-31 10:19:30
Dissemination and Exploitation Plan Open Research Data Pilot 2019-05-31 10:19:32

Take a look to the deliverables list in detail:  detailed list of AMPHORA deliverables.

 Publications

year authors and title journal last update
List of publications.
2018 Alexander Bertrand
Utility Metrics for Assessment and Subset Selection of Input Variables for Linear Estimation [Tips & Tricks]
published pages: 93-99, ISSN: 1053-5888, DOI: 10.1109/MSP.2018.2856632
IEEE Signal Processing Magazine 35/6 2019-05-28

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The information about "AMPHORA" are provided by the European Opendata Portal: CORDIS opendata.

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