EU H2020 Project "P-TEV (Personalized Tissue-Engineered Veins as the first Cure for Patients with..)": description, partecipants, costs and EC-fundings

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P-TEV project word cloud

Explore the words cloud of the P-TEV project. It provides you a very rough idea of what is the project "P-TEV" about.

ulceration insufficiency found paradigm 2019 grafts medicines bicuspid blood extracellular treatment first cured vascular synthetic replace grant positioned donated vein steppingstone risks scaffold relief benefit de leg rejection gmp donor serve function removing marketing market tissue regenerative dysfunctional seeded clean approval suitable cvi stage break immunosuppression 3d allogeneic allotransplantation proof commercialize immunogenic intact autologous veins fill constitutes severe agency added cells chronic recellularization budgetary valves structural transplant tev healthcare breakthrough medical properly matrix subsequently venous avoids verigraft acute unparalleled peripheral turns personalization clinical personalized gap patient patients decellularized medicine progressive surgery dna foreign vessels functioning deep too small replacement engineered

Project "P-TEV" data sheet

The following table provides information about the project.

Coordinator	VERIGRAFT AB Organization address address: ARVID WALLGRENS BACKE 20 city: GOTEBORG postcode: 413 46 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Sweden [SE]
Project website	http://www.verigraft.com
Total cost	2˙184˙603 €
EC max contribution	2˙184˙603 € (100%)
Programme	1. H2020-EU.3.1.3. (Treating and managing disease)
Code Call	H2020-SMEINST-2-2016-2017
Funding Scheme	SME-2
Starting year	2017
Duration (year-month-day)	from 2017-09-01 to 2019-08-31

#	participants	country	role	EC contrib. [€]
1	VERIGRAFT AB	SE (GOTEBORG)	coordinator	2˙184˙603.00

VERIGRAFT AB

SE (GOTEBORG)

coordinator

2˙184˙603.00

Project objective

This project will commercialize P-TEV - a unique personalized tissue engineered vein for the treatment of patients with severe Chronic Venous Insufficiency (CVI). CVI is a progressive medical condition in which the valves of the deep veins of the leg are not functioning properly. The most severe stage is CVI with leg ulceration. No effective treatment is available, and a large number of patients would directly benefit from venous vascular surgery. These patients cannot be cured today because no suitable grafts for replacement of the dysfunctional venous valves have yet been developed. There are no synthetic products which could replace the function of the bicuspid valves found in the leg veins and the risks associated with allotransplantation are too high. VERIGRAFT’s technology is the first one positioned to break this paradigm and fill the existing market gap. The technology allows the personalization of blood vessels by de- and recellularization. In short, a donated tissue is decellularized, removing all immunogenic donor cells and DNA. This results in a clean extracellular matrix scaffold with intact 3D structural properties. Subsequently, this scaffold is seeded with the patient´s own cells, derived from a small sample of peripheral blood. This unique technology turns an allogeneic (“foreign”) tissue into an autologous (“personalized”) one and thus avoids transplant rejection without the need for immunosuppression. The clinical proof-of-concept for P-TEV is established. The project will include the clinical study and GMP process development that will grant VERIGRAFT market access by 2019 and serve as a steppingstone to marketing approval by the European Medicines Agency. The EU-added value of the project is unparalleled, as it constitutes a breakthrough in one of future medicine's most promising fields – advanced personalized regenerative medicine, bringing significant long-term budgetary relief to healthcare systems.

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