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P-TEV TERMINATED

Personalized Tissue-Engineered Veins as the first Cure for Patients with Chronic Venous Insufficiency

Total Cost €

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EC-Contrib. €

0

Partnership

0

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 P-TEV project word cloud

Explore the words cloud of the P-TEV project. It provides you a very rough idea of what is the project "P-TEV" about.

extracellular    proof    grafts    insufficiency    vessels    breakthrough    removing    medicine    medicines    donor    found    seeded    agency    decellularized    replace    severe    break    constitutes    gap    vein    medical    clean    transplant    progressive    healthcare    valves    subsequently    peripheral    personalization    3d    engineered    gmp    first    market    blood    intact    2019    ulceration    function    functioning    positioned    bicuspid    chronic    leg    commercialize    patient    stage    tev    tissue    rejection    steppingstone    donated    foreign    avoids    serve    autologous    risks    replacement    verigraft    approval    veins    turns    benefit    grant    immunogenic    regenerative    cured    paradigm    deep    added    surgery    allotransplantation    recellularization    clinical    synthetic    cvi    de    scaffold    patients    vascular    relief    budgetary    matrix    personalized    acute    dysfunctional    fill    structural    small    immunosuppression    treatment    dna    too    unparalleled    venous    allogeneic    properly    suitable    cells    marketing   

Project "P-TEV" data sheet

The following table provides information about the project.

Coordinator
VERIGRAFT AB 

Organization address
address: ARVID WALLGRENS BACKE 20
city: GOTEBORG
postcode: 413 46
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Sweden [SE]
 Project website http://www.verigraft.com
 Total cost 2˙184˙603 €
 EC max contribution 2˙184˙603 € (100%)
 Programme 1. H2020-EU.3.1.3. (Treating and managing disease)
 Code Call H2020-SMEINST-2-2016-2017
 Funding Scheme SME-2
 Starting year 2017
 Duration (year-month-day) from 2017-09-01   to  2019-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    VERIGRAFT AB SE (GOTEBORG) coordinator 2˙184˙603.00

Map

 Project objective

This project will commercialize P-TEV - a unique personalized tissue engineered vein for the treatment of patients with severe Chronic Venous Insufficiency (CVI). CVI is a progressive medical condition in which the valves of the deep veins of the leg are not functioning properly. The most severe stage is CVI with leg ulceration. No effective treatment is available, and a large number of patients would directly benefit from venous vascular surgery. These patients cannot be cured today because no suitable grafts for replacement of the dysfunctional venous valves have yet been developed. There are no synthetic products which could replace the function of the bicuspid valves found in the leg veins and the risks associated with allotransplantation are too high. VERIGRAFT’s technology is the first one positioned to break this paradigm and fill the existing market gap. The technology allows the personalization of blood vessels by de- and recellularization. In short, a donated tissue is decellularized, removing all immunogenic donor cells and DNA. This results in a clean extracellular matrix scaffold with intact 3D structural properties. Subsequently, this scaffold is seeded with the patient´s own cells, derived from a small sample of peripheral blood. This unique technology turns an allogeneic (“foreign”) tissue into an autologous (“personalized”) one and thus avoids transplant rejection without the need for immunosuppression. The clinical proof-of-concept for P-TEV is established. The project will include the clinical study and GMP process development that will grant VERIGRAFT market access by 2019 and serve as a steppingstone to marketing approval by the European Medicines Agency. The EU-added value of the project is unparalleled, as it constitutes a breakthrough in one of future medicine's most promising fields – advanced personalized regenerative medicine, bringing significant long-term budgetary relief to healthcare systems.

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The information about "P-TEV" are provided by the European Opendata Portal: CORDIS opendata.

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