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P-TEV TERMINATED

Personalized Tissue-Engineered Veins as the first Cure for Patients with Chronic Venous Insufficiency

Total Cost €

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EC-Contrib. €

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Partnership

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 P-TEV project word cloud

Explore the words cloud of the P-TEV project. It provides you a very rough idea of what is the project "P-TEV" about.

serve    suitable    ulceration    synthetic    allogeneic    3d    progressive    function    engineered    extracellular    medicine    grant    cvi    replacement    patients    vein    immunogenic    relief    cells    tev    medical    proof    patient    deep    blood    commercialize    allotransplantation    chronic    seeded    autologous    break    steppingstone    peripheral    functioning    vessels    immunosuppression    venous    stage    recellularization    marketing    scaffold    donor    valves    approval    decellularized    found    veins    avoids    added    fill    gap    transplant    severe    bicuspid    budgetary    2019    personalized    subsequently    turns    benefit    intact    matrix    donated    paradigm    small    healthcare    medicines    cured    rejection    dysfunctional    first    removing    constitutes    replace    surgery    de    market    too    gmp    vascular    tissue    treatment    dna    unparalleled    agency    grafts    insufficiency    structural    acute    leg    regenerative    verigraft    positioned    risks    breakthrough    personalization    foreign    clean    clinical    properly   

Project "P-TEV" data sheet

The following table provides information about the project.

Coordinator
VERIGRAFT AB 

Organization address
address: ARVID WALLGRENS BACKE 20
city: GOTEBORG
postcode: 413 46
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Sweden [SE]
 Project website http://www.verigraft.com
 Total cost 2˙184˙603 €
 EC max contribution 2˙184˙603 € (100%)
 Programme 1. H2020-EU.3.1.3. (Treating and managing disease)
 Code Call H2020-SMEINST-2-2016-2017
 Funding Scheme SME-2
 Starting year 2017
 Duration (year-month-day) from 2017-09-01   to  2019-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    VERIGRAFT AB SE (GOTEBORG) coordinator 2˙184˙603.00

Map

 Project objective

This project will commercialize P-TEV - a unique personalized tissue engineered vein for the treatment of patients with severe Chronic Venous Insufficiency (CVI). CVI is a progressive medical condition in which the valves of the deep veins of the leg are not functioning properly. The most severe stage is CVI with leg ulceration. No effective treatment is available, and a large number of patients would directly benefit from venous vascular surgery. These patients cannot be cured today because no suitable grafts for replacement of the dysfunctional venous valves have yet been developed. There are no synthetic products which could replace the function of the bicuspid valves found in the leg veins and the risks associated with allotransplantation are too high. VERIGRAFT’s technology is the first one positioned to break this paradigm and fill the existing market gap. The technology allows the personalization of blood vessels by de- and recellularization. In short, a donated tissue is decellularized, removing all immunogenic donor cells and DNA. This results in a clean extracellular matrix scaffold with intact 3D structural properties. Subsequently, this scaffold is seeded with the patient´s own cells, derived from a small sample of peripheral blood. This unique technology turns an allogeneic (“foreign”) tissue into an autologous (“personalized”) one and thus avoids transplant rejection without the need for immunosuppression. The clinical proof-of-concept for P-TEV is established. The project will include the clinical study and GMP process development that will grant VERIGRAFT market access by 2019 and serve as a steppingstone to marketing approval by the European Medicines Agency. The EU-added value of the project is unparalleled, as it constitutes a breakthrough in one of future medicine's most promising fields – advanced personalized regenerative medicine, bringing significant long-term budgetary relief to healthcare systems.

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The information about "P-TEV" are provided by the European Opendata Portal: CORDIS opendata.

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