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Personalized Tissue-Engineered Veins as the first Cure for Patients with Chronic Venous Insufficiency

Total Cost €


EC-Contrib. €






 P-TEV project word cloud

Explore the words cloud of the P-TEV project. It provides you a very rough idea of what is the project "P-TEV" about.

unparalleled    suitable    progressive    turns    added    venous    3d    severe    cured    patients    too    engineered    small    acute    replace    blood    market    tissue    removing    relief    ulceration    de    veins    found    matrix    functioning    cvi    medical    positioned    stage    subsequently    breakthrough    patient    serve    benefit    bicuspid    treatment    gmp    synthetic    leg    personalization    recellularization    transplant    approval    budgetary    vessels    deep    proof    rejection    insufficiency    agency    medicines    donor    first    function    decellularized    paradigm    steppingstone    avoids    tev    constitutes    grafts    autologous    dna    seeded    scaffold    cells    chronic    vascular    dysfunctional    personalized    allogeneic    replacement    properly    fill    2019    gap    donated    clinical    allotransplantation    extracellular    grant    healthcare    clean    commercialize    medicine    intact    valves    surgery    structural    risks    break    immunosuppression    regenerative    marketing    immunogenic    peripheral    verigraft    vein    foreign   

Project "P-TEV" data sheet

The following table provides information about the project.


Organization address
postcode: 413 46
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Sweden [SE]
 Project website
 Total cost 2˙184˙603 €
 EC max contribution 2˙184˙603 € (100%)
 Programme 1. H2020-EU.3.1.3. (Treating and managing disease)
 Code Call H2020-SMEINST-2-2016-2017
 Funding Scheme SME-2
 Starting year 2017
 Duration (year-month-day) from 2017-09-01   to  2019-08-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    VERIGRAFT AB SE (GOTEBORG) coordinator 2˙184˙603.00


 Project objective

This project will commercialize P-TEV - a unique personalized tissue engineered vein for the treatment of patients with severe Chronic Venous Insufficiency (CVI). CVI is a progressive medical condition in which the valves of the deep veins of the leg are not functioning properly. The most severe stage is CVI with leg ulceration. No effective treatment is available, and a large number of patients would directly benefit from venous vascular surgery. These patients cannot be cured today because no suitable grafts for replacement of the dysfunctional venous valves have yet been developed. There are no synthetic products which could replace the function of the bicuspid valves found in the leg veins and the risks associated with allotransplantation are too high. VERIGRAFT’s technology is the first one positioned to break this paradigm and fill the existing market gap. The technology allows the personalization of blood vessels by de- and recellularization. In short, a donated tissue is decellularized, removing all immunogenic donor cells and DNA. This results in a clean extracellular matrix scaffold with intact 3D structural properties. Subsequently, this scaffold is seeded with the patient´s own cells, derived from a small sample of peripheral blood. This unique technology turns an allogeneic (“foreign”) tissue into an autologous (“personalized”) one and thus avoids transplant rejection without the need for immunosuppression. The clinical proof-of-concept for P-TEV is established. The project will include the clinical study and GMP process development that will grant VERIGRAFT market access by 2019 and serve as a steppingstone to marketing approval by the European Medicines Agency. The EU-added value of the project is unparalleled, as it constitutes a breakthrough in one of future medicine's most promising fields – advanced personalized regenerative medicine, bringing significant long-term budgetary relief to healthcare systems.

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The information about "P-TEV" are provided by the European Opendata Portal: CORDIS opendata.

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