Opendata, web and dolomites

CL_Exocytosis SIGNED

“Molecular dissection of cytotoxic lymphocyte exocytosis

Total Cost €


EC-Contrib. €






 CL_Exocytosis project word cloud

Explore the words cloud of the CL_Exocytosis project. It provides you a very rough idea of what is the project "CL_Exocytosis" about.

horizon    strategies    insights    cell    cooperate    exocytosis    deciphering    gain    diagnosis    implicated    scientific    human    offers    explore    phd    effector    recycling    membrane    defects    proteins    isoforms    expand    live    cg    first    laboratory    mass    prompted    cl    molecular    onset    genes    contribution    exocytic    move    life    promise    opportunity    lab    imaging    bryceson    cytotoxic    components    activation    cargo    causative    constituents    guide    profoundly    regulation    disorders    expertise    pathological    molecule    interaction    successfully    therapy    motivated    excellence    severe    successful    granule    disease    mechanistic    re    regulated    fusion    lymphocyte    critical    plan    immunology    dissecting    genetic    my    syndromes    throughput    mutations    yearning    munc13    endosome    ms    context    me    syntaxin    11    academic    plasma    underlying    vesicular    delivering    immune    limited    career    healthy    hyperinflammatory    spectrometry    cytosolic    cytotoxicity    quantitative    host    dr    purse   

Project "CL_Exocytosis" data sheet

The following table provides information about the project.


Organization address
address: Nobels Vag 5
postcode: 17177

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Sweden [SE]
 Total cost 173˙857 €
 EC max contribution 173˙857 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-01-01   to  2020-12-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KAROLINSKA INSTITUTET SE (STOCKHOLM) coordinator 173˙857.00


 Project objective

My PhD experience in the field of immunology focused on deciphering vesicular pathways underlying T cell activation profoundly motivated my move to Dr. Bryceson’s lab, which offers a unique opportunity to explore cytotoxic lymphocyte (CL) exocytosis in the context of human disease. Cytotoxic lymphocyte exocytosis is critical for life, with mutations in genes required for cytotoxicity causative of severe, early-onset hyperinflammatory syndromes. Genetic studies have identified several cytosolic proteins required for CL exocytosis. However, understanding of how these proteins cooperate for exocytosis, their interaction partners and how their activities are regulated is still limited. I propose strategies to gain insight to the molecular regulation of human CL exocytosis. First, prompted by genetic studies, I aim to study the contribution of two distinct Munc13-4 isoforms to lymphocyte cytotoxicity by dissecting their role in cytotoxic granule (CG) exocytosis using advanced live-cell imaging as well as identifying their interaction partners using quantitative mass spectrometry (MS). Second, recycling endosome (RE) have recently been implicated in CG exocytosis, delivering syntaxin-11, an effector molecule required for CG fusion, to the plasma membrane. I plan to use a high-throughput MS approach to identify RE constituents and cargo in order to define new components that may be critical for CG exocytosis. Results will provide novel mechanistic insights to CL exocytosis, which will also be relevant for other exocytic systems. Providing detailed molecular understanding of lymphocyte cytotoxicity in both healthy and pathological conditions, insights promise to guide improved diagnosis and therapy of immune disorders associated with defects in lymphocyte cytotoxicity. Yearning to build a successful academic career, the excellence of the host laboratory will allow me to successfully purse this project and expand technical expertise and my scientific horizon.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "CL_EXOCYTOSIS" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email ( and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "CL_EXOCYTOSIS" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

ToMComputations (2019)

How other minds are represented in the human brain: Neural computations underlying Theory of Mind

Read More  

MingleIFT (2020)

Multi-color and single-molecule fluorescence imaging of intraflagellar transport in the phasmid chemosensory cilia of C. Elegans

Read More  

MIGPSC (2018)

Shaping the European Migration Policy: the role of the security industry

Read More