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STARDUST SIGNED

in vivo optogeneticS, elecTrophysiology and phArmacology with an ultRasonically-powered DUST for Parkinson's Disease

Total Cost €

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EC-Contrib. €

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Partnership

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Project "STARDUST" data sheet

The following table provides information about the project.

Coordinator
AARHUS UNIVERSITET 

Organization address
address: NORDRE RINGGADE 1
city: AARHUS C
postcode: 8000
website: www.au.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Project website http://www.project-stardust.eu
 Total cost 3˙803˙057 €
 EC max contribution 3˙787˙932 € (100%)
 Programme 1. H2020-EU.1.2.1. (FET Open)
 Code Call H2020-FETOPEN-1-2016-2017
 Funding Scheme RIA
 Starting year 2017
 Duration (year-month-day) from 2017-10-01   to  2021-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    AARHUS UNIVERSITET DK (AARHUS C) coordinator 967˙948.00
2    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) participant 592˙855.00
3    BIOMODICS APS DK (KGS LYNGBY) participant 485˙736.00
4    VIB VZW BE (ZWIJNAARDE - GENT) participant 417˙635.00
5    FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V. DE (MUNCHEN) participant 375˙121.00
6    UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK IE (Cork) participant 360˙513.00
7    HUMBOLDT-UNIVERSITAET ZU BERLIN DE (BERLIN) participant 356˙000.00
8    SPINVERSE OY FI (ESPOO) participant 171˙622.00
9    Universidade Federal do Pará BR (Belém) participant 60˙500.00

Map

 Project objective

The main goal of the STARDUST project is to realize a novel wireless implantable and independent micro-scale device (200x200x200 µm3) enabling in-vivo electrophysiology, optogenetics and ultra-localized drug delivery in freely moving animals. The device will be used to target specific neural circuits of the brain and test a new therapeutic approach for Parkinson’s Disease (PD). The methods used in this project are based on cutting-edge miniaturized technology combining integrated chips, microelectromechanical systems (MEMS), local drug delivery, integrated electrodes and micro-scale light emitting diodes (µLEDs). STARDUST will benefit from these advances and for the first time provide an implantable ultrasonically-powered miniaturized device for in-vivo optogenetics, local drug delivery and electrophysiological monitoring – all in one single device. The proposed device is expected to provide an output power of 1-20 mW/mm2 for optogenetics with two different wavelengths, one for neuron activation and one for triggering drug-delivery; STARDUST will provide proof of concept. The main novelty of the STARDUST project is the convergence of multiple, interdisciplinary fields including optogenetics, triggered drug-delivery, miniaturized ultrasonic energy harvesting, material science and nanoelectronics. The main ambition of the project is to develop a new technology platform to be used for future implantable in-vivo optogenetic devices for monitoring and treating diseases, with an optional local drug delivery add-on beyond 2025. Establishing proof of concept of the STARDUST platform will be the foundation for other applications within photodynamic therapy such as cancer treatment and other neurological and non-neurological disorders.

 Deliverables

List of deliverables.
Annual Meeting 1 Documents, reports 2020-01-28 16:31:21
Plan for Quality Assurance Documents, reports 2020-01-28 16:31:21
Project website and logo Documents, reports 2020-01-28 16:31:21
Kick-off Meeting Documents, reports 2020-01-28 16:31:21
Dissemination, exploitation and communication plan Documents, reports 2020-01-28 16:31:21

Take a look to the deliverables list in detail:  detailed list of STARDUST deliverables.

 Publications

year authors and title journal last update
List of publications.
2019 Samira Ztaou, Marianne Amalric
Contribution of cholinergic interneurons to striatal pathophysiology in Parkinson\'s disease
published pages: 1-10, ISSN: 0197-0186, DOI: 10.1016/j.neuint.2019.02.019
Neurochemistry International 126 2020-01-28
2018 Samira Ztaou, Juliette Lhost, Isabelle Watabe, Giulia Torromino, Marianne Amalric
Striatal cholinergic interneurons regulate cognitive and affective dysfunction in partially dopamine-depleted mice
published pages: 2988-3004, ISSN: 0953-816X, DOI: 10.1111/ejn.14153
European Journal of Neuroscience 48/9 2020-01-28
2018 Kazumasa Oda, Johannes Vierock, Satomi Oishi, Silvia Rodriguez-Rozada, Reiya Taniguchi, Keitaro Yamashita, J. Simon Wiegert, Tomohiro Nishizawa, Peter Hegemann, Osamu Nureki
Crystal structure of the red light-activated channelrhodopsin Chrimson
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-06421-9
Nature Communications 9/1 2020-01-28
2017 Jonas Wietek, Silvia Rodriguez-Rozada, Janine Tutas, Federico Tenedini, Christiane Grimm, Thomas G. Oertner, Peter Soba, Peter Hegemann, J. Simon Wiegert
Anion-conducting channelrhodopsins with tuned spectra and modified kinetics engineered for optogenetic manipulation of behavior
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-017-14330-y
Scientific Reports 7/1 2020-01-28
2018 Yinth Andrea Bernal Sierra, Benjamin R. Rost, Martin Pofahl, António Miguel Fernandes, Ramona A. Kopton, Sylvain Moser, Dominik Holtkamp, Nicola Masala, Prateep Beed, John J. Tukker, Silvia Oldani, Wolfgang Bönigk, Peter Kohl, Herwig Baier, Franziska Schneider-Warme, Peter Hegemann, Heinz Beck, Reinhard Seifert, Dietmar Schmitz
Potassium channel-based optogenetic silencing
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-07038-8
Nature Communications 9/1 2020-01-28
2018 Christiane Grimm, Arita Silapetere, Arend Vogt, Yinth Andrea Bernal Sierra, Peter Hegemann
Electrical properties, substrate specificity and optogenetic potential of the engineered light-driven sodium pump eKR2
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-27690-w
Scientific Reports 8/1 2020-01-28

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The information about "STARDUST" are provided by the European Opendata Portal: CORDIS opendata.

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