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STARDUST SIGNED

in vivo optogeneticS, elecTrophysiology and phArmacology with an ultRasonically-powered DUST for Parkinson's Disease

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

STARDUST project word cloud

Explore the words cloud of the STARDUST project. It provides you a very rough idea of what is the project "STARDUST" about.

electrodes photodynamic monitoring energy realize ultrasonically neuron triggered novelty multiple foundation single diodes chips local cancer electrophysiology proof miniaturized optogenetic science 2025 powered leds interdisciplinary nanoelectronics benefit circuits therapy animals optogenetics combining neurological ultra device establishing neural diseases wavelengths electrophysiological light output of parkinson implantable independent treatment mems platform disease m3 material optional convergence wireless therapeutic edge disorders pd emitting stardust mw treating 200x200x200 ambition activation brain localized power first moving microelectromechanical drug cutting vivo micro harvesting mm2 ultrasonic time add

Project "STARDUST" data sheet

The following table provides information about the project.

Coordinator	AARHUS UNIVERSITET Organization address address: NORDRE RINGGADE 1 city: AARHUS C postcode: 8000 website: www.au.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Denmark [DK]
Project website	http://www.project-stardust.eu
Total cost	3˙803˙057 €
EC max contribution	3˙787˙932 € (100%)
Programme	1. H2020-EU.1.2.1. (FET Open)
Code Call	H2020-FETOPEN-1-2016-2017
Funding Scheme	RIA
Starting year	2017
Duration (year-month-day)	from 2017-10-01 to 2021-09-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	AARHUS UNIVERSITET AARHUS UNIVERSITET Organization address address: NORDRE RINGGADE 1 city: AARHUS C postcode: 8000 website: www.au.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (AARHUS C)	coordinator	967˙948.00
2	CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS Organization address address: RUE MICHEL ANGE 3 city: PARIS postcode: 75794 website: www.cnrs.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	participant	592˙855.00
3	BIOMODICS APS BIOMODICS APS Organization address address: STENGARDS ALLE 31 A city: KGS LYNGBY postcode: 2800 website: www.biomodics.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (KGS LYNGBY)	participant	485˙736.00
4	VIB VZW VIB VZW Organization address address: RIJVISSCHESTRAAT 120 city: ZWIJNAARDE - GENT postcode: 9052 website: www.vib.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (ZWIJNAARDE - GENT)	participant	417˙635.00
5	FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V. FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V. Organization address address: HANSASTRASSE 27C city: MUNCHEN postcode: 80686 website: www.fraunhofer.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (MUNCHEN)	participant	375˙121.00
6	UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK Organization address address: WESTERN ROAD city: Cork postcode: T12 YN60 website: www.ucc.ie contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IE (Cork)	participant	360˙513.00
7	HUMBOLDT-UNIVERSITAET ZU BERLIN HUMBOLDT-UNIVERSITAET ZU BERLIN Organization address address: UNTER DEN LINDEN 6 city: BERLIN postcode: 10117 website: www.hu-berlin.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (BERLIN)	participant	356˙000.00
8	SPINVERSE OY SPINVERSE OY Organization address address: TEKNIIKANTIE 14 city: ESPOO postcode: 2150 website: www.spinverse.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FI (ESPOO)	participant	171˙622.00
9	Universidade Federal do Pará Universidade Federal do Pará Organization address address: Rua Augusto Corrêa 01 city: Belém postcode: 66075-110 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BR (Belém)	participant	60˙500.00

Map

Project objective

The main goal of the STARDUST project is to realize a novel wireless implantable and independent micro-scale device (200x200x200 µm3) enabling in-vivo electrophysiology, optogenetics and ultra-localized drug delivery in freely moving animals. The device will be used to target specific neural circuits of the brain and test a new therapeutic approach for Parkinson’s Disease (PD). The methods used in this project are based on cutting-edge miniaturized technology combining integrated chips, microelectromechanical systems (MEMS), local drug delivery, integrated electrodes and micro-scale light emitting diodes (µLEDs). STARDUST will benefit from these advances and for the first time provide an implantable ultrasonically-powered miniaturized device for in-vivo optogenetics, local drug delivery and electrophysiological monitoring – all in one single device. The proposed device is expected to provide an output power of 1-20 mW/mm2 for optogenetics with two different wavelengths, one for neuron activation and one for triggering drug-delivery; STARDUST will provide proof of concept. The main novelty of the STARDUST project is the convergence of multiple, interdisciplinary fields including optogenetics, triggered drug-delivery, miniaturized ultrasonic energy harvesting, material science and nanoelectronics. The main ambition of the project is to develop a new technology platform to be used for future implantable in-vivo optogenetic devices for monitoring and treating diseases, with an optional local drug delivery add-on beyond 2025. Establishing proof of concept of the STARDUST platform will be the foundation for other applications within photodynamic therapy such as cancer treatment and other neurological and non-neurological disorders.

Deliverables

List of deliverables.
Annual Meeting 1	Documents, reports	2020-01-28 16:31:21
Plan for Quality Assurance	Documents, reports	2020-01-28 16:31:21
Project website and logo	Documents, reports	2020-01-28 16:31:21
Kick-off Meeting	Documents, reports	2020-01-28 16:31:21
Dissemination, exploitation and communication plan	Documents, reports	2020-01-28 16:31:21

Take a look to the deliverables list in detail: detailed list of STARDUST deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2019	Samira Ztaou, Marianne Amalric Contribution of cholinergic interneurons to striatal pathophysiology in Parkinson\'s disease published pages: 1-10, ISSN: 0197-0186, DOI: 10.1016/j.neuint.2019.02.019	Neurochemistry International 126	2020-01-28
2018	Samira Ztaou, Juliette Lhost, Isabelle Watabe, Giulia Torromino, Marianne Amalric Striatal cholinergic interneurons regulate cognitive and affective dysfunction in partially dopamine-depleted mice published pages: 2988-3004, ISSN: 0953-816X, DOI: 10.1111/ejn.14153	European Journal of Neuroscience 48/9	2020-01-28
2018	Kazumasa Oda, Johannes Vierock, Satomi Oishi, Silvia Rodriguez-Rozada, Reiya Taniguchi, Keitaro Yamashita, J. Simon Wiegert, Tomohiro Nishizawa, Peter Hegemann, Osamu Nureki Crystal structure of the red light-activated channelrhodopsin Chrimson published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-06421-9	Nature Communications 9/1	2020-01-28
2017	Jonas Wietek, Silvia Rodriguez-Rozada, Janine Tutas, Federico Tenedini, Christiane Grimm, Thomas G. Oertner, Peter Soba, Peter Hegemann, J. Simon Wiegert Anion-conducting channelrhodopsins with tuned spectra and modified kinetics engineered for optogenetic manipulation of behavior published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-017-14330-y	Scientific Reports 7/1	2020-01-28
2018	Yinth Andrea Bernal Sierra, Benjamin R. Rost, Martin Pofahl, AntÃ³nio Miguel Fernandes, Ramona A. Kopton, Sylvain Moser, Dominik Holtkamp, Nicola Masala, Prateep Beed, John J. Tukker, Silvia Oldani, Wolfgang BÃ¶nigk, Peter Kohl, Herwig Baier, Franziska Schneider-Warme, Peter Hegemann, Heinz Beck, Reinhard Seifert, Dietmar Schmitz Potassium channel-based optogenetic silencing published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-07038-8	Nature Communications 9/1	2020-01-28
2018	Christiane Grimm, Arita Silapetere, Arend Vogt, Yinth Andrea Bernal Sierra, Peter Hegemann Electrical properties, substrate specificity and optogenetic potential of the engineered light-driven sodium pump eKR2 published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-27690-w	Scientific Reports 8/1	2020-01-28

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The information about "STARDUST" are provided by the European Opendata Portal: CORDIS opendata.