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ENABLE SIGNED

Advancing cell based therapies by supporting implant survival

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EC-Contrib. €

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Project "ENABLE" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITEIT TWENTE 

Organization address
address: DRIENERLOLAAN 5
city: ENSCHEDE
postcode: 7522 NB
website: www.utwente.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 1˙500˙000 €
 EC max contribution 1˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-STG
 Funding Scheme ERC-STG
 Starting year 2018
 Duration (year-month-day) from 2018-01-01   to  2022-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITEIT TWENTE NL (ENSCHEDE) coordinator 1˙500˙000.00

Map

 Project objective

Tissue engineering aims at the creation of living implants to replace, repair, or regenerate damaged, diseased, or aged tissues, which holds tremendous possibilities to both extend our lives and improve our quality of life. During the last decades, our ability to create small tissues to heal small animals e.g. mice and rats has taken a breath taking leap. However, we have relentlessly struggled to create viable tissues of human-relevant sizes. Creating solid large tissues imposes lethal nutrient diffusion limitations, which causes the living implant to suffer from starvation, loss of function, and inevitable failure.

I hypothesize that this key challenge can be tackled by recruiting and developing advanced enabling nano- and micro-technologies. The ENABLE project begins with the design and development of a widely applicable platform that will enable large solid engineered tissues to survive and function by actively sustaining the implants metabolic needs. This platform is based on a unique two pronged strategy that rely on distinct technologies: oxygen releasing micromaterials, fabricated using a next-generation droplet generator, to enable short term survival of the implant, while embedded bioprinting will endow implants with a complex 3D vascular network to enable their long term survival. As proof of principle, the effects of ENABLE’s platform will be investigated using a critical bone defect in which I analyse the survival and function of the created living implants.

The anticipated outcomes of this proposal are three fold: first, I will develop a next-generation engineered tissue that will overcome the current size restrictions via the use of enabling technologies; second, I will reveal new knowledge on the role of the oxygen tension on vascularization and tissue formation by enabling control over the in vivo oxygen tension; and third, I will develop a novel strategy that enables the treatment of critical bone defects.

 Publications

year authors and title journal last update
List of publications.
2019 Tom Kamperman, Bas van Loo, Melvin Gurian, Sieger Henke, Marcel Karperien, Jeroen Leijten
On-the-fly exchangeable microfluidic nozzles for facile production of various monodisperse micromaterials
published pages: 1977-1984, ISSN: 1473-0197, DOI: 10.1039/c9lc00054b
Lab on a Chip 19/11 2019-08-30
2018 Jungmok Seo, Jung-Youn Shin, Jeroen Leijten, Oju Jeon, Ayça Bal Öztürk, Jeroen Rouwkema, Yuancheng Li, Su Ryon Shin, Hadi Hajiali, Eben Alsberg, Ali Khademhosseini
Interconnectable Dynamic Compression Bioreactors for Combinatorial Screening of Cell Mechanobiology in Three Dimensions
published pages: 13293-13303, ISSN: 1944-8244, DOI: 10.1021/acsami.7b17991
ACS Applied Materials & Interfaces 10/16 2019-08-30
2018 Tom Kamperman, Marcel Karperien, Séverine Le Gac, Jeroen Leijten
Single-Cell Microgels: Technology, Challenges, and Applications
published pages: 850-865, ISSN: 0167-7799, DOI: 10.1016/j.tibtech.2018.03.001
Trends in Biotechnology 36/8 2019-08-30
2018 Tom Kamperman, Vasileios D. Trikalitis, Marcel Karperien, Claas Willem Visser, Jeroen Leijten
Ultrahigh-Throughput Production of Monodisperse and Multifunctional Janus Microparticles Using in-Air Microfluidics
published pages: 23433-23438, ISSN: 1944-8244, DOI: 10.1021/acsami.8b05227
ACS Applied Materials & Interfaces 10/28 2019-08-30
2019 Elahe Hadavi, Jeroen Leijten, Marten Engelse, Eelco de Koning, Pascal Jonkheijm, Marcel Karperien, Aart van Apeldoorn
Microwell Scaffolds Using Collagen-IV and Laminin-111 Lead to Improved Insulin Secretion of Human Islets
published pages: 71-81, ISSN: 1937-3384, DOI: 10.1089/ten.tec.2018.0336
Tissue Engineering Part C: Methods 25/2 2019-08-30
2018 Elahe Hadavi, Jeroen Leijten, Jenny Brinkmann, Pascal Jonkheijm, Marcel Karperien, Aart van Apeldoorn
Fibronectin and Collagen IV Microcontact Printing Improves Insulin Secretion by INS1E Cells
published pages: 628-636, ISSN: 1937-3384, DOI: 10.1089/ten.tec.2018.0151
Tissue Engineering Part C: Methods 24/11 2019-08-30

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The information about "ENABLE" are provided by the European Opendata Portal: CORDIS opendata.

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