ENABLE SIGNED
Advancing cell based therapies by supporting implant survival
Total Cost €
0EC-Contrib. €
0Partnership
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0ENABLE project word cloud
Explore the words cloud of the ENABLE project. It provides you a very rough idea of what is the project "ENABLE" about.
Project "ENABLE" data sheet
The following table provides information about the project.
| Coordinator |
UNIVERSITEIT TWENTE
Organization address contact info |
| Coordinator Country | Netherlands [NL] |
| Total cost | 1˙500˙000 € |
| EC max contribution | 1˙500˙000 € (100%) |
| Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
| Code Call | ERC-2017-STG |
| Funding Scheme | ERC-STG |
| Starting year | 2018 |
| Duration (year-month-day) | from 2018-01-01 to 2022-12-31 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | UNIVERSITEIT TWENTE | NL (ENSCHEDE) | coordinator | 1˙500˙000.00 |
Map
Project objective
Tissue engineering aims at the creation of living implants to replace, repair, or regenerate damaged, diseased, or aged tissues, which holds tremendous possibilities to both extend our lives and improve our quality of life. During the last decades, our ability to create small tissues to heal small animals e.g. mice and rats has taken a breath taking leap. However, we have relentlessly struggled to create viable tissues of human-relevant sizes. Creating solid large tissues imposes lethal nutrient diffusion limitations, which causes the living implant to suffer from starvation, loss of function, and inevitable failure.
I hypothesize that this key challenge can be tackled by recruiting and developing advanced enabling nano- and micro-technologies. The ENABLE project begins with the design and development of a widely applicable platform that will enable large solid engineered tissues to survive and function by actively sustaining the implants metabolic needs. This platform is based on a unique two pronged strategy that rely on distinct technologies: oxygen releasing micromaterials, fabricated using a next-generation droplet generator, to enable short term survival of the implant, while embedded bioprinting will endow implants with a complex 3D vascular network to enable their long term survival. As proof of principle, the effects of ENABLE’s platform will be investigated using a critical bone defect in which I analyse the survival and function of the created living implants.
The anticipated outcomes of this proposal are three fold: first, I will develop a next-generation engineered tissue that will overcome the current size restrictions via the use of enabling technologies; second, I will reveal new knowledge on the role of the oxygen tension on vascularization and tissue formation by enabling control over the in vivo oxygen tension; and third, I will develop a novel strategy that enables the treatment of critical bone defects.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2019 |
Tom Kamperman, Bas van Loo, Melvin Gurian, Sieger Henke, Marcel Karperien, Jeroen Leijten On-the-fly exchangeable microfluidic nozzles for facile production of various monodisperse micromaterials published pages: 1977-1984, ISSN: 1473-0197, DOI: 10.1039/c9lc00054b |
Lab on a Chip 19/11 | 2019-08-30 |
| 2018 |
Jungmok Seo, Jung-Youn Shin, Jeroen Leijten, Oju Jeon, Ayça Bal Öztürk, Jeroen Rouwkema, Yuancheng Li, Su Ryon Shin, Hadi Hajiali, Eben Alsberg, Ali Khademhosseini Interconnectable Dynamic Compression Bioreactors for Combinatorial Screening of Cell Mechanobiology in Three Dimensions published pages: 13293-13303, ISSN: 1944-8244, DOI: 10.1021/acsami.7b17991 |
ACS Applied Materials & Interfaces 10/16 | 2019-08-30 |
| 2018 |
Tom Kamperman, Marcel Karperien, Séverine Le Gac, Jeroen Leijten Single-Cell Microgels: Technology, Challenges, and Applications published pages: 850-865, ISSN: 0167-7799, DOI: 10.1016/j.tibtech.2018.03.001 |
Trends in Biotechnology 36/8 | 2019-08-30 |
| 2018 |
Tom Kamperman, Vasileios D. Trikalitis, Marcel Karperien, Claas Willem Visser, Jeroen Leijten Ultrahigh-Throughput Production of Monodisperse and Multifunctional Janus Microparticles Using in-Air Microfluidics published pages: 23433-23438, ISSN: 1944-8244, DOI: 10.1021/acsami.8b05227 |
ACS Applied Materials & Interfaces 10/28 | 2019-08-30 |
| 2019 |
Elahe Hadavi, Jeroen Leijten, Marten Engelse, Eelco de Koning, Pascal Jonkheijm, Marcel Karperien, Aart van Apeldoorn Microwell Scaffolds Using Collagen-IV and Laminin-111 Lead to Improved Insulin Secretion of Human Islets published pages: 71-81, ISSN: 1937-3384, DOI: 10.1089/ten.tec.2018.0336 |
Tissue Engineering Part C: Methods 25/2 | 2019-08-30 |
| 2018 |
Elahe Hadavi, Jeroen Leijten, Jenny Brinkmann, Pascal Jonkheijm, Marcel Karperien, Aart van Apeldoorn Fibronectin and Collagen IV Microcontact Printing Improves Insulin Secretion by INS1E Cells published pages: 628-636, ISSN: 1937-3384, DOI: 10.1089/ten.tec.2018.0151 |
Tissue Engineering Part C: Methods 24/11 | 2019-08-30 |
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The information about "ENABLE" are provided by the European Opendata Portal: CORDIS opendata.