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VIREVOL SIGNED

Cells and giant viruses: a win-win co-evolution

Total Cost €

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EC-Contrib. €

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Partnership

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 VIREVOL project word cloud

Explore the words cloud of the VIREVOL project. It provides you a very rough idea of what is the project "VIREVOL" about.

chilensis    evolutionary    life    infectious    structure    cellular    despite    encodes    cytoplasmic    external    hosts    share    sizes    mb    relative    followed    roughly    resembling    questions    continue    discovery    responsible    homologues    progressive    viruses    hypothesize    made    viral       pandoraviridae    particles    cellulose    led    revisit    reaching    micro    mimivirus    tree    transition    morphologies    virus    organization    unveil    pandoraviruses    amoebal    proteins    coevolution    giant    tegument    trajectory    first    synthesis    virion    hijacking    preliminary    icosahedral    3mb    relatives    encoding    origin    nuclear    intriguing    pithovirus    last       mimiviridae    isolated    aquatic    living    rigid    amphora    packaging    genome    megavirus    cycle    rod    thousands    raised    plastic    machinery    virions    1000    discovered    position    characterization    laboratory    shaped    world    host    microscopy    pandoravirions    permafrost    genes    mollivirions    light    siberian    spherical    families    gain    risk    links    team    ancestor    visible    mollivirus   

Project "VIREVOL" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 2˙246˙453 €
 EC max contribution 2˙246˙453 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-ADG
 Funding Scheme ERC-ADG
 Starting year 2019
 Duration (year-month-day) from 2019-10-01   to  2024-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 2˙246˙453.00

Map

 Project objective

The discovery of Mimivirus, the first icosahedral virus visible by light microscopy, was followed by the characterization of many other relatives. Its aquatic relative Megavirus chilensis, has a 1.2 Mb genome and encodes more than 1000 proteins, 2/3 unique to the Mimiviridae. Their infectious cycle is cytoplasmic. During the last 10 years, my laboratory discovered three other giant virus families: -the pandoraviridae, with their unique amphora-shaped 1µm long virion morphologies, genome sizes reaching 3Mb and encoding thousands of proteins, most of which without homologues in the cellular or the viral world – the mollivirus, which was isolated from a 30,000 years old Siberian permafrost sample, presents common features with the pandoraviruses. They share 60 unique genes and the roughly spherical (0.6µm) mollivirions present an external tegument resembling the pandoravirions. Both viruses have an early nuclear phase – the pithovirus, despite its amphora-shaped virions, has a fully cytoplasmic cycle. Our work raised questions on the origin of these intriguing viral families and their position in the tree of life. My project is unique as it will address the coevolution of these viruses and their amoebal hosts by focusing on specific features of the virions in two overall aims. 1) Promising preliminary results led us to hypothesize that a progressive transition from the rigid icosahedral virions to the more plastic amphora-shaped particles was made possible through hijacking of the host cellulose synthesis pathway by the ancestor of pandoraviruses. 2) The icosahedral mimivirus package its genome in a complex rod-shaped structure. My team will investigate this structure to unveil possible evolutionary links with the genome packaging systems in the cellular world. We will characterize the machinery responsible for such organization. These two high-risk/high-gain aims will continue to revisit the concept of virus and their evolutionary trajectory in the living world.

 Deliverables

List of deliverables.
Data management Plan Open Research Data Pilot 2020-02-27 15:23:50

Take a look to the deliverables list in detail:  detailed list of VIREVOL deliverables.

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The information about "VIREVOL" are provided by the European Opendata Portal: CORDIS opendata.

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