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HybridHeart SIGNED

Development of the first fully biocompatible, soft actuated heart: combining in situ tissue engineering and soft robotics

Total Cost €

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EC-Contrib. €

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Partnership

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Project "HybridHeart" data sheet

The following table provides information about the project.

Coordinator
ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM 

Organization address
address: MEIBERGDREEF 15
city: AMSTERDAM
postcode: 1105AZ
website: www.amc.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Project website http://www.hybridheart.eu
 Total cost 3˙035˙550 €
 EC max contribution 3˙035˙550 € (100%)
 Programme 1. H2020-EU.1.2.1. (FET Open)
 Code Call H2020-FETOPEN-1-2016-2017
 Funding Scheme RIA
 Starting year 2017
 Duration (year-month-day) from 2017-11-01   to  2022-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM NL (AMSTERDAM) coordinator 705˙000.00
2    TECHNISCHE UNIVERSITEIT EINDHOVEN NL (EINDHOVEN) participant 585˙000.00
3    SCUOLA SUPERIORE DI STUDI UNIVERSITARI E DI PERFEZIONAMENTO S ANNA IT (PISA) participant 454˙375.00
4    XELTIS BV NL (EINDHOVEN) participant 443˙675.00
5    STICHTING NEDERLANDSE WETENSCHAPPELIJK ONDERZOEK INSTITUTEN NL (UTRECHT) participant 396˙250.00
6    EM-TEC GMBH WERNER HEINZE DE (FINNING) participant 311˙145.00
7    DUALIS MEDTECH GMBH DE (SEEFELD) participant 140˙104.00

Map

 Project objective

The Hybrid Heart consortium envisions to develop and bring to the clinic soft biocompatible artificial organs. These will consist of a soft robotics shell with actuators (‘artificial muscles’) and sensors, enabling completely natural motion. The inner lining and structures will be made by in situ tissue engineering (TE), ensuring biocompatibility of blood-contacting surfaces. As the first step, the consortium will develop the Hybrid Heart, which can completely replace a patient’s heart in a procedure similar to a heart transplant, to provide a cure for heart failure, which affects ~23 million people worldwide. Currently, patients with end-stage heart failure either receive a heart transplant, if available, or long-term mechanical circulatory support, which causes severe complications. To achieve the ambitious goal of providing a permanent cure for these patients, the participants will, in parallel, develop the components of the Hybrid Heart: 1) a soft elastomeric robotics shell containing actuators and sensors, 2) scaffolds for in situ TE of inner lining, valves and vessels and 3) a wireless energy transfer system. These components together will form the full Hybrid Heart, which will be soft, adaptable, wireless and fully bio- and hemocompatible. Both functionality as well as biocompatibility of the Hybrid Heart will be shown in a Proof-of-Principle study in the chronic sheep model at the end of the project. The Hybrid Heart project will be carried out by an interdisciplinary group of (academic) researchers and high-tech SMEs, with experience in cardiac surgery, TE, soft robotics and engineering. The technology underlying the Hybrid Heart is applicable to a range of soft robotics-based artificial organs, including the bowel, lung, or muscle structures (limbs). Replacing an entire organ with bioinspired robotic elements, TE biocompatible surfaces, artificial sensors, and an external power source allows for an off-the-shelf therapy for patients with organ failure.

 Deliverables

List of deliverables.
Data Management Plan Open Research Data Pilot 2019-09-04 15:59:05
Cross-institutional knowledge exchange: TE scaffolds and matrix polymers Other 2019-09-04 15:59:05
Whitepaper on requirements and constraints of combining technologies Documents, reports 2019-09-04 15:59:04
Website and logo Websites, patent fillings, videos etc. 2019-09-04 15:59:04

Take a look to the deliverables list in detail:  detailed list of HybridHeart deliverables.

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The information about "HYBRIDHEART" are provided by the European Opendata Portal: CORDIS opendata.

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