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TRIBAL SIGNED

A TRranslational approach to Identify Biomarkers for Asthma and Lung function impairment

Total Cost €

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EC-Contrib. €

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Partnership

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Project "TRIBAL" data sheet

The following table provides information about the project.

Coordinator
KAROLINSKA INSTITUTET 

Organization address
address: Nobels Vag 5
city: STOCKHOLM
postcode: 17177
website: www.ki.se

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Sweden [SE]
 Total cost 1˙500˙000 €
 EC max contribution 1˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-STG
 Funding Scheme ERC-STG
 Starting year 2017
 Duration (year-month-day) from 2017-12-01   to  2022-11-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KAROLINSKA INSTITUTET SE (STOCKHOLM) coordinator 1˙500˙000.00

Map

 Project objective

Asthma is a chronic inflammatory disease of the airways that cause symptoms like wheezing and breathlessness. In children, asthma is the most common chronic disease and according to the WHO, more than 300 million people are affected globally. There is no curative treatment available. Persistence of childhood asthma into adult life is associated with lung function impairment and increased risk of chronic obstructive pulmonary disease, COPD. Evidence is now emerging that adult diseases, like COPD, may have their origin early in life. However, there are no established biomarkers that can accurately monitor asthma progression or predict development of COPD in adults. In this TRIBAL project, I will capitalize on rich longitudinal data and repeated bio-sampling from the Swedish BAMSE study, a world-leading population-based birth cohort of 4,089 participants with a new 24-year follow-up starting in 2017. A key aim with the new follow-up is to identify young adults in their 20s with persistent asthma and pre-stage COPD by advanced lung function assessment that includes bronchodilator and nitrogen washout tests. In TRIBAL, the unique setup is deep phenotyping of these patients describing different aspects of the respiratory system, as well as molecular characteristics of relevant bio-samples and cells. Disease-related biomarkers and involved mechanisms, from gene to protein, will be identified from early childhood to adulthood. Both the innate and the adapted immune system with detailed cell characterization will be explored in relation to exposure and disease development. Specifically, with this novel approach I will address the time point during childhood when disease processes related to persistent asthma and pre-stage COPD were initiated. The ultimate goal in TRIBAL is to provide new knowledge for targeted preventive efforts in children at risk of adult chronic lung disease, and to identify potential targets for new asthma and COPD drugs.

 Publications

year authors and title journal last update
List of publications.
2020 Simon Kebede Merid, Alexei Novoloaca, Gemma C. Sharp, Leanne K. Küpers, Alvin T. Kho, Ritu Roy, Lu Gao, Isabella Annesi-Maesano, Pooja Jain, Michelle Plusquin, Manolis Kogevinas, Catherine Allard, Florianne O. Vehmeijer, Nabila Kazmi, Lucas A. Salas, Faisal I. Rezwan, Hongmei Zhang, Sylvain Sebert, Darina Czamara, Sheryl L. Rifas-Shiman, Phillip E. Melton, Debbie A. Lawlor, Göran Pershagen, Carr
Epigenome-wide meta-analysis of blood DNA methylation in newborns and children identifies numerous loci related to gestational age
published pages: , ISSN: 1756-994X, DOI: 10.1186/s13073-020-0716-9
Genome Medicine 12/1 2020-03-23
2020 Korneliusz Golebski, Michael Kabesch, Erik Melén, Uroš Potočnik, Cornelis M. van Drunen, Susanne Reinarts, Anke H. Maitland-van der Zee, Susanne J.H. Vijverberg
Childhood asthma in the new omics era
published pages: 155-161, ISSN: 1528-4050, DOI: 10.1097/aci.0000000000000626
Current Opinion in Allergy and Clinical Immunology 20/2 2020-03-23
2020 Emmanouela Sdona, Jenny Hallberg, Niklas Andersson, Sandra Ekström, Susanne Rautiainen, Niclas Håkansson, Alicja Wolk, Inger Kull, Erik Melén, Anna Bergström
Dietary antioxidant intake in school age and lung function development up to adolescence
published pages: 1900990, ISSN: 0903-1936, DOI: 10.1183/13993003.00990-2019
European Respiratory Journal 55/2 2020-03-23
2018 Erik Melén, Robert Barouki, Maeve Barry, H. Marike Boezen, Barbara Hoffmann, Susanne Krauss-Etschmann, Gerard H. Koppelman, Bertil Forsberg
Promoting respiratory public health through epigenetics research: an ERS Environment Health Committee workshop report
published pages: 1702410, ISSN: 0903-1936, DOI: 10.1183/13993003.02410-2017
European Respiratory Journal 51/4 2019-06-11
2018 Cheng-Jian Xu, Cilla Söderhäll, Mariona Bustamante, Nour Baïz, Olena Gruzieva, Ulrike Gehring, Dan Mason, Leda Chatzi, Mikel Basterrechea, Sabrina Llop, Maties Torrent, Francesco Forastiere, Maria Pia Fantini, Karin C Lødrup Carlsen, Tari Haahtela, Andréanne Morin, Marjan Kerkhof, Simon Kebede Merid, Bianca van Rijkom, Soesma A Jankipersadsing, Marc Jan Bonder, Stephane Ballereau, Cornelis J Vermeulen, Raul Aguirre-Gamboa, Johan C de Jongste, Henriette A Smit, Ashish Kumar, Göran Pershagen, Stefano Guerra, Judith Garcia-Aymerich, Dario Greco, Lovisa Reinius, Rosemary R C McEachan, Raf Azad, Vegard Hovland, Petter Mowinckel, Harri Alenius, Nanna Fyhrquist, Nathanaël Lemonnier, Johann Pellet, Charles Auffray, Pieter van der Vlies, Cleo C van Diemen, Yang Li, Cisca Wijmenga, Mihai G Netea, Miriam F Moffatt, William O C M Cookson, Josep M Anto, Jean Bousquet, Tiina Laatikainen, Catherine Laprise, Kai-Håkon Carlsen, Davide Gori, Daniela Porta, Carmen Iñiguez, Jose Ramon Bilbao, Manolis Kogevinas, John Wright, Bert Brunekreef, Juha Kere, Martijn C Nawijn, Isabella Annesi-Maesano, Jordi Sunyer, Erik Melén, Gerard H Koppelman
DNA methylation in childhood asthma: an epigenome-wide meta-analysis
published pages: , ISSN: 2213-2600, DOI: 10.1016/S2213-2600(18)30052-3
The Lancet Respiratory Medicine 2019-06-11

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The information about "TRIBAL" are provided by the European Opendata Portal: CORDIS opendata.

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