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Endothelial RNA Modifications in Vascular Homeostasis and Disease

Total Cost €


EC-Contrib. €






 MODVASC project word cloud

Explore the words cloud of the MODVASC project. It provides you a very rough idea of what is the project "MODVASC" about.

immunoprecipitation    consolidate    methylated    functional    mechanisms    methyltransferase    strategies    pro    basal    eukaryotic    inflammatory    fate    posttranscriptional    cover    n6    base    cardiovascular    stress    vivo    metabolism    western    single    induce    adenosine    functions    catalyzed    accumulating    explore    clinical    rna    molecular    biochemical    suggests    preliminary    modvasc    pivotal    vascular    tree    critically    describe    sequencing    m6a    modification    prevalent    organ    cell    multiprotein    phenotype    interactions    canonical    entire    stimuli    world    atherosclerosis    contribution    transcriptome    therapeutic    environmental    risk    nucleotides    mrna    mortality    completely    regulator    followed    arterial    disease    function    relevance    nucleotide    patients    discovery    unknown    endothelial    140    unpublished    alphabet    methylation    orchestrate    regulate    activation    venous    protein    homeostasis    cells    critical    biomarkers    biology    position    play    modifications   

Project "MODVASC" data sheet

The following table provides information about the project.


Organization address
address: KINGS GATE
postcode: NE1 7RU

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 1˙499˙250 €
 EC max contribution 1˙499˙250 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-STG
 Funding Scheme ERC-STG
 Starting year 2018
 Duration (year-month-day) from 2018-06-01   to  2023-05-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

Endothelial cells cover the entire arterial and venous tree, and play a pivotal role in vascular and organ homeostasis. In general, cardiovascular risk factors induce endothelial cell activation towards a pro-inflammatory phenotype leading to atherosclerosis, a major cause of mortality in the Western world. Understanding the mechanisms that orchestrate endothelial cell functions and response to environmental stimuli is essential for the discovery and development of novel biomarkers and therapeutic strategies in vascular disease. RNA base modifications increase the RNA alphabet from the 4 canonical nucleotides to more than 140. Adenosine methylation at the N6 position (m6A) is the most prevalent RNA modification in eukaryotic mRNA and is catalyzed by a multiprotein methyltransferase complex. Accumulating recent evidence suggests that m6A RNA methylation is a critical posttranscriptional regulator of RNA metabolism. In preliminary unpublished work we have identified methylated RNA targets, which may critically regulate endothelial cell functions. Since the impact of m6A RNA methylation on vascular function is completely unknown, MODVASC aims to explore the role of m6A RNA methylation in vascular growth, homeostasis and disease. By m6A-RNA immunoprecipitation followed by RNA-sequencing we will identify the transcriptome-wide m6A RNA methylation in endothelial cells under basal and stress conditions. With the help of advanced molecular biology and biochemical methods, we will describe in single nucleotide level the impact of m6A RNA methylation on mRNA fate and RNA-protein interactions and define its functional consequences in endothelial cell functions. In vivo studies will consolidate the impact of endothelial RNA methylation on vascular growth and homeostasis as well as its contribution to atherosclerosis. Finally, MODVASC will evaluate the clinical relevance of our findings in patients with cardiovascular disease.

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The information about "MODVASC" are provided by the European Opendata Portal: CORDIS opendata.

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