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mRNP-PackArt SIGNED

Nuclear mRNA Packaging and mRNP Architecture

Total Cost €

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EC-Contrib. €

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Partnership

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Project "mRNP-PackArt" data sheet

The following table provides information about the project.

Coordinator
JUSTUS-LIEBIG-UNIVERSITAET GIESSEN 

Organization address
address: LUDWIGSTRASSE 23
city: GIESSEN
postcode: 35390
website: www.uni-giessen.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙991˙387 €
 EC max contribution 1˙991˙387 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-COG
 Funding Scheme ERC-COG
 Starting year 2018
 Duration (year-month-day) from 2018-06-01   to  2023-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    JUSTUS-LIEBIG-UNIVERSITAET GIESSEN DE (GIESSEN) coordinator 1˙991˙387.00

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 Project objective

An important step of gene expression is the formation of a messenger ribonucleoprotein particle (mRNP). The messenger RNA (mRNA) is synthesized by RNA polymerase II transcribing a protein-coding gene. The mRNA is processed, i.e. capped, spliced and polyadenylated, and packaged into an mRNP by binding of RNA-binding proteins (RBPs). The RBPs bound to the mRNA are essential for the stability of the mRNP, control nuclear mRNA export and often determine cytoplasmic processes such as mRNA localization, translation and decay. Thus, the formation and composition of an mRNP is important for the posttranscriptional control of gene expression. Despite its essential nature, the mechanism of nuclear mRNP packaging and the architecture of an mRNP are still poorly understood due to the fact that mRNPs contain many different mRNAs. The overall goal of this proposal is to elucidate the mechanism of mRNP formation and the molecular structure of an mRNP. Specifically, In aim 1, we will determine and quantify the protein composition of a specific mRNP including different stages during its biogenesis; In aim 2, we will illuminate the molecular mechanism of mRNP packaging; and In aim 3, we will elucidate the architecture of an mRNP by cross-linking mass spectrometry and electron microscopy. These aims will be achieved by combining novel RNP purification strategies and the powerful biochemistry of the model organism S. cerevisiae to purify a specific mRNP with recent advances in high-end mass spectrometry and electron microscopy. In summary, the expected results of this project will show the architecture of an mRNP in its dynamic nature. mRNP packaging will be understood for the first time on a mechanistic as well as structural level. Thus, the results of this project will break new ground in our understanding of this fundamental cellular process and will also provide insights into how defects in this process lead to disease.

 Deliverables

List of deliverables.
Research Data Open Research Data Pilot 2019-10-01 09:18:44

Take a look to the deliverables list in detail:  detailed list of mRNP-PackArt deliverables.

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The information about "MRNP-PACKART" are provided by the European Opendata Portal: CORDIS opendata.

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