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FeelAgain SIGNED

Restoring natural feelings from missing or damaged peripheral nervous system by model-driven neuroprosthesis

Total Cost €

0

EC-Contrib. €

0

Partnership

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 FeelAgain project word cloud

Explore the words cloud of the FeelAgain project. It provides you a very rough idea of what is the project "FeelAgain" about.

suffer    fibers    associable    first    tests    natural    inputs    movements    sensory    skin    types    device    interface    leg    merge    stimulation    brain    functional    consequently    perceive    subject    lack    ulcers    protocols    embodiment    neuropathic    model    mimic    clinical    structures    placement    examination    neuropathy    avoidance    computational    risk    relief    aberrant    prevention    interfaces    peripheral    amputees    restoration    amputee    counterbalancing    sciatic    periphery    fatigue    ulcer    tools    sole    action    subjects    prone    potentials    amputations    functionalities    loop    geometry    walking    diabetic    prosthetic    rely    foot    technological    nerve    perceived    recorded    constructed    translate    feedback    framework    transduction    sensations    pain    boosting    body    neuroprosthesis    signals    falls    mechanical    patients    damage    causes    restoring    surgical    due    efficacy    feelagain    amputation    conceptual    optimize    placed    electrical    deformations    validated    prosthesis    interventional    modeling    foreign    neural    sensorized   

Project "FeelAgain" data sheet

The following table provides information about the project.

Coordinator		 EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH 

Organization address
address: Raemistrasse 101
city: ZUERICH
postcode: 8092
website: https://www.ethz.ch/de.html

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country Switzerland [CH]
 Total cost 1˙499˙637 €
 EC max contribution 1˙499˙637 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-STG
 Funding Scheme ERC-STG
 Starting year 2018
 Duration (year-month-day) from 2018-04-01   to  2023-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH CH (ZUERICH) coordinator 1˙385˙032.00
2    INSTITUT MIHAJLO PUPIN RS (BEOGRAD) participant 114˙605.00

Map

 Project objective

Due to sensory loss diabetic patients are prone to falls and to foot ulcers, which consequently increase the risk of amputations. Because of the lack of sensory feedback amputees experience falls, perceive the prosthesis as a foreign body and therefore do not rely on it during walking. This causes counterbalancing movements that increase fatigue. Both types of patients suffer neuropathic pain, associable to aberrant sensory inputs. Neural pathways between the periphery and the brain are still functional above the damage or the amputation. Targeting these structures with peripheral neural interfaces could allow the restoration of natural sensory functionalities. The aim of project is to develop the first neuroprosthesis restoring natural foot sensations, through sciatic nerve stimulation, to patients with diabetic neuropathy or leg amputation. To that aim we will develop a detailed computational model of the sensory loop of the sciatic nerve. It will merge the electrical stimulation effects on sensory fibers and transduction of mechanical deformations of the skin into action potentials. Modelling results will be validated. Applying this modeling framework we will optimize the geometry of a peripheral neural interface, its surgical placement and define stimulation protocols that mimic natural sensory feedback responses. Effective device for feedback restoration will be constructed, able to translate the signals recorded by sensorized sole placed under the prosthetic or diabetic foot into the natural foot sensations perceived by subject. The interventional tools for embodiment boosting and pain relief will be developed. Clinical tests on amputee and diabetic subjects will assess the efficacy of the FeelAgain conceptual and technological framework by examination of pain, embodiment, ulcer prevention, falls avoidance and walking ability.

 Publications

year authors and title journal last update
List of publications.
2019 Francesco Maria Petrini, Marko Bumbasirevic, Giacomo Valle, Vladimir Ilic, Pavle Mijović, Paul Čvančara, Federica Barberi, Natalija Katic, Dario Bortolotti, David Andreu, Knut Lechler, Aleksandar Lesic, Sanja Mazic, Bogdan Mijović, David Guiraud, Thomas Stieglitz, Asgeir Alexandersson, Silvestro Micera, Stanisa Raspopovic
Sensory feedback restoration in leg amputees improves walking speed, metabolic cost and phantom pain
published pages: 1356-1363, ISSN: 1078-8956, DOI: 10.1038/s41591-019-0567-3 		Nature Medicine 25/9 2020-01-30
2019 Francesco Maria Petrini, Giacomo Valle, Marko Bumbasirevic, Federica Barberi, Dario Bortolotti, Paul Cvancara, Arthur Hiairrassary, Pavle Mijovic, Atli Örn Sverrisson, Alessandra Pedrocchi, Jean-Louis Divoux, Igor Popovic, Knut Lechler, Bogdan Mijovic, David Guiraud, Thomas Stieglitz, Asgeir Alexandersson, Silvestro Micera, Aleksandar Lesic, Stanisa Raspopovic
Enhancing functional abilities and cognitive integration of the lower limb prosthesis
published pages: eaav8939, ISSN: 1946-6234, DOI: 10.1126/scitranslmed.aav8939 		Science Translational Medicine 11/512 2020-01-30
2019 Francesco M. Petrini, Alberto Mazzoni, Jacopo Rigosa, Federica Giambattistelli, Giuseppe Granata, Beatrice Barra, Alessandra Pampaloni, Eugenio Guglielmelli, Loredana Zollo, Marco Capogrosso, Silvestro Micera, Stanisa Raspopovic
Microneurography as a tool to develop decoding algorithms for peripheral neuro-controlled hand prostheses
published pages: , ISSN: 1475-925X, DOI: 10.1186/s12938-019-0659-9 		BioMedical Engineering OnLine 18/1 2020-01-30

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The information about "FEELAGAIN" are provided by the European Opendata Portal: CORDIS opendata.

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