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Enabling Catalytic Cross Couplings with only Zinc Electrophiles, Nucleophiles and Boranes

Total Cost €


EC-Contrib. €






 ECO-ZEN project word cloud

Explore the words cloud of the ECO-ZEN project. It provides you a very rough idea of what is the project "ECO-ZEN" about.

selective    pairs    successful    completely    industry    coupling    noble    acid    organoboranes    impetus    substrates    group    fundamental    react    horizons    electrophile    freedom    arylboronic    precious    concertedly    nucleophilic    miyaura    ir    unprecedented    cog    metal    erc    conceivable    directed    elementoboration    sp3c    boranes    stereospecific    anions    ubiquitous    synthesis    dominated    fluoroboration    boron    species    functionalisation    cross    frustrated    acids    expensive    transformations    couplings    free    requiring    opened    academia    mediated    meta    extend    innovation    area    catalysed    toxic    transform    overarching    intermediates    compounds    abundance    alkynes    suzuki    borylation    pioneering    toxicity    reactions    frustration    catalysis    catalysts    utilising    multiple    pd    ideas    zinc    components    vital    hetero    consolidated    subsequent    pot    trans    avenues    electrophiles    afford    herein    integrates    chemistry    abundant    lewis    stg    reaction    combinations    earth    ortho    sear    derivatives    synthetic   

Project "ECO-ZEN" data sheet

The following table provides information about the project.


Organization address
postcode: EH8 9YL

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website
 Total cost 2˙070˙093 €
 EC max contribution 2˙070˙093 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-COG
 Funding Scheme ERC-COG
 Starting year 2018
 Duration (year-month-day) from 2018-05-01   to  2023-04-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF EDINBURGH UK (EDINBURGH) coordinator 1˙803˙454.00


 Project objective

This high-impact, challenging CoG Proposal integrates multiple novel ideas in boron and zinc chemistry into an overarching project to open up new horizons across synthesis and catalysis. The Applicant’s successful ERC StG has opened up new avenues of pioneering research in main group element mediated transformations that were not conceivable before the work was done. Components of this proposal extend out from the StG into new, exciting research areas that are completely different. Developing low toxicity earth abundant catalysts for important transformations is vital to the EU with the focus herein being on; (i) the Suzuki-Miyaura (S-M) cross coupling reaction which is ubiquitous in industry and academia, and (ii) the formation of organoboranes that are essential synthetic intermediates. Both of these are currently dominated by toxic, expensive and low abundance precious metal catalysts (e.g. Pd, Ir). This project will deliver innovation through utilising combinations of main group Lewis acids and nucleophilic anions that do not react with each other, i.e. are frustrated pairs. This “frustration” enables the two species to concertedly transform substrates to achieve:

(i) precious metal-free S-M cross coupling reactions of sp3C electrophiles catalysed by zinc and boron compounds, including stereospecific couplings and one pot two step cross electrophile couplings

(ii) trans-elementoboration of alkynes, including the unprecedented fluoroboration of alkynes

Other new approaches will be developed to access novel (hetero)arylboronic acid derivatives using only simple boranes and without requiring noble metal catalysts, specifically: (i) boron directed C-H borylation and (ii) directed ortho borylation to enable subsequent meta selective SEAr C-H functionalisation.

This CoG will afford the freedom and impetus via consolidated funding to undertake fundamental research to deliver high impact results, including developing a new area of cross coupling catalysis research.


year authors and title journal last update
List of publications.
2018 Valerio Fasano, Jessica Cid, Richard J. Procter, Emily Ross, Michael J. Ingleson
Selective Boryl-Anion Migration in a Vinyl sp 2 −sp 3 Diborane Induced by Soft Borane Lewis Acids
published pages: 13293-13297, ISSN: 1433-7851, DOI: 10.1002/anie.201808216
Angewandte Chemie International Edition 57/40 2019-10-01
2019 James E. Radcliffe, Valerio Fasano, Ralph W. Adams, Peiran You, Michael J. Ingleson
Reductive α-borylation of α,β-unsaturated esters using NHC–BH 3 activated by I 2 as a metal-free route to α-boryl esters
published pages: 1434-1441, ISSN: 2041-6520, DOI: 10.1039/c8sc04305a
Chemical Science 10/5 2019-10-01
2018 Rachel J. Kahan, Daniel L. Crossley, Jessica Cid, James E. Radcliffe, Michael J. Ingleson
Synthesis, Characterization, and Functionalization of 1-Boraphenalenes
published pages: 8084-8088, ISSN: 1433-7851, DOI: 10.1002/anie.201803180
Angewandte Chemie International Edition 57/27 2019-10-01

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The information about "ECO-ZEN" are provided by the European Opendata Portal: CORDIS opendata.

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