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Enabling Catalytic Cross Couplings with only Zinc Electrophiles, Nucleophiles and Boranes

Total Cost €


EC-Contrib. €






 ECO-ZEN project word cloud

Explore the words cloud of the ECO-ZEN project. It provides you a very rough idea of what is the project "ECO-ZEN" about.

sp3c    catalysed    pairs    ortho    chemistry    functionalisation    fundamental    stereospecific    integrates    boranes    utilising    alkynes    meta    species    miyaura    toxicity    elementoboration    concertedly    successful    transform    industry    multiple    ubiquitous    abundant    combinations    precious    catalysts    stg    zinc    earth    acids    ideas    couplings    unprecedented    group    sear    frustrated    consolidated    cog    catalysis    arylboronic    reactions    impetus    compounds    reaction    extend    completely    nucleophilic    boron    noble    freedom    overarching    mediated    organoboranes    subsequent    selective    abundance    herein    academia    frustration    avenues    metal    hetero    derivatives    afford    directed    innovation    opened    fluoroboration    pioneering    pd    anions    borylation    expensive    dominated    components    vital    coupling    lewis    ir    toxic    electrophile    electrophiles    conceivable    free    synthesis    acid    requiring    trans    substrates    erc    pot    transformations    horizons    suzuki    intermediates    react    cross    synthetic    area   

Project "ECO-ZEN" data sheet

The following table provides information about the project.


Organization address
postcode: EH8 9YL

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website
 Total cost 2˙070˙093 €
 EC max contribution 2˙070˙093 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-COG
 Funding Scheme ERC-COG
 Starting year 2018
 Duration (year-month-day) from 2018-05-01   to  2023-04-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF EDINBURGH UK (EDINBURGH) coordinator 1˙803˙454.00


 Project objective

This high-impact, challenging CoG Proposal integrates multiple novel ideas in boron and zinc chemistry into an overarching project to open up new horizons across synthesis and catalysis. The Applicant’s successful ERC StG has opened up new avenues of pioneering research in main group element mediated transformations that were not conceivable before the work was done. Components of this proposal extend out from the StG into new, exciting research areas that are completely different. Developing low toxicity earth abundant catalysts for important transformations is vital to the EU with the focus herein being on; (i) the Suzuki-Miyaura (S-M) cross coupling reaction which is ubiquitous in industry and academia, and (ii) the formation of organoboranes that are essential synthetic intermediates. Both of these are currently dominated by toxic, expensive and low abundance precious metal catalysts (e.g. Pd, Ir). This project will deliver innovation through utilising combinations of main group Lewis acids and nucleophilic anions that do not react with each other, i.e. are frustrated pairs. This “frustration” enables the two species to concertedly transform substrates to achieve:

(i) precious metal-free S-M cross coupling reactions of sp3C electrophiles catalysed by zinc and boron compounds, including stereospecific couplings and one pot two step cross electrophile couplings

(ii) trans-elementoboration of alkynes, including the unprecedented fluoroboration of alkynes

Other new approaches will be developed to access novel (hetero)arylboronic acid derivatives using only simple boranes and without requiring noble metal catalysts, specifically: (i) boron directed C-H borylation and (ii) directed ortho borylation to enable subsequent meta selective SEAr C-H functionalisation.

This CoG will afford the freedom and impetus via consolidated funding to undertake fundamental research to deliver high impact results, including developing a new area of cross coupling catalysis research.


year authors and title journal last update
List of publications.
2018 Valerio Fasano, Jessica Cid, Richard J. Procter, Emily Ross, Michael J. Ingleson
Selective Boryl-Anion Migration in a Vinyl sp 2 −sp 3 Diborane Induced by Soft Borane Lewis Acids
published pages: 13293-13297, ISSN: 1433-7851, DOI: 10.1002/anie.201808216
Angewandte Chemie International Edition 57/40 2019-10-01
2019 James E. Radcliffe, Valerio Fasano, Ralph W. Adams, Peiran You, Michael J. Ingleson
Reductive α-borylation of α,β-unsaturated esters using NHC–BH 3 activated by I 2 as a metal-free route to α-boryl esters
published pages: 1434-1441, ISSN: 2041-6520, DOI: 10.1039/c8sc04305a
Chemical Science 10/5 2019-10-01
2018 Rachel J. Kahan, Daniel L. Crossley, Jessica Cid, James E. Radcliffe, Michael J. Ingleson
Synthesis, Characterization, and Functionalization of 1-Boraphenalenes
published pages: 8084-8088, ISSN: 1433-7851, DOI: 10.1002/anie.201803180
Angewandte Chemie International Edition 57/27 2019-10-01

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The information about "ECO-ZEN" are provided by the European Opendata Portal: CORDIS opendata.

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