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Opendata, web and dolomites

ZIDOMS SIGNED

Using Zebrafish as a novel tool to Improve the Diagnosis and Outcome of Marfan Syndrome

Total Cost €

EC-Contrib. €

Partnership

Views

ZIDOMS project word cloud

Explore the words cloud of the ZIDOMS project. It provides you a very rough idea of what is the project "ZIDOMS" about.

spectrum complications proposing evaluation significance unequivocally supportive validate mfs leads predictive personalized lifelong rare classify recent screening animal patients causal diagnosis mutations efficient classifications de optimal marfan look discovery of clinic combination gene model cure mutation supervisor medicine fibrillin deleterious aid zebrafish dr proof drug strategy tool precision genetic physiology linked unmet syndrome clinical exists expertise treatments synergy prevent historical detection models technological mortality backer treatment quick patient symptoms researcher syndromic personal disorder definitive fbn1 prof classification nevertheless identification cardiovascular disease unknown advantage libraries biological variants relies sips morbidity potentially therapies positive

Project "ZIDOMS" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITEIT GENT Organization address address: SINT PIETERSNIEUWSTRAAT 25 city: GENT postcode: 9000 website: http://www.ugent.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Belgium [BE]
Total cost	172˙800 €
EC max contribution	172˙800 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2017
Funding Scheme	MSCA-IF-EF-RI
Starting year	2018
Duration (year-month-day)	from 2018-09-01 to 2020-08-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITEIT GENT UNIVERSITEIT GENT Organization address address: SINT PIETERSNIEUWSTRAAT 25 city: GENT postcode: 9000 website: http://www.ugent.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (GENT)	coordinator	172˙800.00

Map

Project objective

Recent technological advances have brought the implementation of personal and precision medicine in the clinic within reach. In this project, we are proposing to use zebrafish as a novel, efficient tool to improve the clinical diagnosis and treatment of Marfan Syndrome (MFS), a rare genetic disorder with a wide spectrum of clinical features. Since there is no definitive cure for MFS, patients need lifelong supportive treatment to prevent morbidity and mortality related to cardiovascular complications. Together with the detection of a number of syndromic symptoms, positive diagnosis of MFS relies on the identification of a deleterious mutation in the fibrillin-1 (FBN1) gene. Nevertheless, genetic testing often leads to the discovery of FBN1 variants which are not unequivocally linked to disease development. Current practice relies on the evaluation of historical and predictive parameters to classify variants of unknown significance as potentially causal mutations, but no biological model exists to efficiently validate the genetic classifications. This project aims to make optimal use of the combination of the know-how of the researcher, Dr. Sips, in the field of cardiovascular physiology and animal models of disease, with the clinical expertise of the supervisor, Prof. De Backer, in the diagnosis and treatment of MFS patients. The goal is to develop a zebrafish-based model that will allow for the quick classification of unknown variants in the FBN1 gene to aid in the diagnosis of MFS. In addition, the model will allow an efficient screening of drug libraries to look for potential new therapies, which might make it possible to find patient-specific treatments. Taken together, this project aims to take advantage of the synergy between the researcher and the supervisor in order to develop a novel strategy for a personalized approach to medicine. MFS is studied as a proof-of-concept clinical challenge with unmet needs in diagnosis and treatment.

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The information about "ZIDOMS" are provided by the European Opendata Portal: CORDIS opendata.