Opendata, web and dolomites

PhenomeNal SIGNED

Inheritance, expressivity and epistasis hidden behindthe phenotypic landscape of natural populations

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 PhenomeNal project word cloud

Explore the words cloud of the PhenomeNal project. It provides you a very rough idea of what is the project "PhenomeNal" about.

yeast    entire    deeper    continuous    fr    frame    date    heritability    variation    marry    efforts    datasets    evident    expression    lay    connect    architecture    century    monogenic    interactions    expressivity    mutations    011    resists    genome    confounded    altogether    populations    1002genomes    display    dissect    causes    components    clear    law    mendel    strasbg    effect    variability    accompanying    environment    first    little    natural    population    loci    http    plus    allelic    awesome    relatively    biology    genetic    isolates    epigenetic    observations    explained    completion    powerful    heritable    hampered    landscape    phenotyping    association    genomics    elucidating    traits    eukaryote    plan    phenotypic    phenome    missing    throughput    lack    foundation    diversity    resequencing    al    concerning    complete    rediscovery    shown    model    causal    inheritance    indicate    advantage    generalization    variants    backgrounds    budding    hidden   

Project "PhenomeNal" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITE DE STRASBOURG 

Organization address
address: RUE BLAISE PASCAL 4
city: STRASBOURG
postcode: 67081
website: http://www.unistra.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 1˙999˙882 €
 EC max contribution 1˙999˙882 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-COG
 Funding Scheme ERC-COG
 Starting year 2018
 Duration (year-month-day) from 2018-09-01   to  2023-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITE DE STRASBOURG FR (STRASBOURG) coordinator 1˙999˙882.00

Map

 Project objective

Elucidating the causes of the awesome phenotypic diversity observed in natural populations is a major challenge in biology. It is now clear that the understanding of traits is not only hampered by non-heritable factors such as the environment and epigenetic variation, but also confounded by the lack of complete knowledge concerning the genetic components of traits. More than a century after the rediscovery of Mendel’s law, the genetic architecture of traits still resists generalization. First, this is increasingly evident as shown by recent genome-wide association studies, where identified causal loci explained relatively little of the heritability of most complex traits, leading to the “missing heritability”. Second, we also have recently shown that monogenic mutations can display a significant, variable and continuous phenotypic expression, called expressivity, across different genetic backgrounds. Altogether, these observations clearly indicate that a better understanding of the genetic architecture of traits requires a deeper knowledge of the variability of the phenotypic effect of genetic variants across an entire population. In the frame of the Phenome'N'al project, I plan to marry classical but high-throughput genetic methods with new approaches based on population genomics to connect the phenotypic and allelic landscape by taking advantage of the powerful budding yeast model system. With our recent completion of the whole genome resequencing of over 1,011 natural isolates (http://1002genomes.u-strasbg.fr/), plus the accompanying phenotyping efforts, we have currently one of the best understanding of the natural genetic and phenotypic diversity of any eukaryote model system to date. These datasets will lay the foundation of Phenome'N'al, which aims to dissect the inheritance, expressivity and genetic interactions hidden behind the phenotypic landscape of an entire natural population.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "PHENOMENAL" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "PHENOMENAL" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

POLAR (2020)

Polarization and its discontents: does rising economic inequality undermine the foundations of liberal societies?

Read More  

METAPoF (2019)

Metaphor as the Purpose of the Firm

Read More  

H I C I (2020)

Transcriptional and epigenetic control of tissue regenerative HB-EGF in autoimmune CNS inflammation

Read More