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PhenomeNal SIGNED

Inheritance, expressivity and epistasis hidden behindthe phenotypic landscape of natural populations

Total Cost €

0

EC-Contrib. €

0

Partnership

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 PhenomeNal project word cloud

Explore the words cloud of the PhenomeNal project. It provides you a very rough idea of what is the project "PhenomeNal" about.

first    deeper    genetic    1002genomes    observations    foundation    biology    dissect    yeast    hampered    landscape    interactions    variation    variants    clear    entire    genomics    powerful    law    011    strasbg    inheritance    plan    completion    architecture    relatively    phenome    association    phenotypic    diversity    al    little    accompanying    heritability    continuous    display    lack    fr    connect    marry    traits    phenotyping    advantage    rediscovery    hidden    populations    resists    mutations    expressivity    missing    explained    altogether    isolates    backgrounds    lay    date    mendel    evident    elucidating    genome    indicate    allelic    natural    http    variability    causes    loci    expression    efforts    datasets    epigenetic    frame    causal    resequencing    complete    awesome    plus    heritable    generalization    throughput    effect    eukaryote    components    confounded    budding    concerning    environment    model    monogenic    population    shown    century   

Project "PhenomeNal" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITE DE STRASBOURG 

Organization address
address: RUE BLAISE PASCAL 4
city: STRASBOURG
postcode: 67081
website: http://www.unistra.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 1˙999˙882 €
 EC max contribution 1˙999˙882 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-COG
 Funding Scheme ERC-COG
 Starting year 2018
 Duration (year-month-day) from 2018-09-01   to  2023-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITE DE STRASBOURG FR (STRASBOURG) coordinator 1˙999˙882.00

Map

 Project objective

Elucidating the causes of the awesome phenotypic diversity observed in natural populations is a major challenge in biology. It is now clear that the understanding of traits is not only hampered by non-heritable factors such as the environment and epigenetic variation, but also confounded by the lack of complete knowledge concerning the genetic components of traits. More than a century after the rediscovery of Mendel’s law, the genetic architecture of traits still resists generalization. First, this is increasingly evident as shown by recent genome-wide association studies, where identified causal loci explained relatively little of the heritability of most complex traits, leading to the “missing heritability”. Second, we also have recently shown that monogenic mutations can display a significant, variable and continuous phenotypic expression, called expressivity, across different genetic backgrounds. Altogether, these observations clearly indicate that a better understanding of the genetic architecture of traits requires a deeper knowledge of the variability of the phenotypic effect of genetic variants across an entire population. In the frame of the Phenome'N'al project, I plan to marry classical but high-throughput genetic methods with new approaches based on population genomics to connect the phenotypic and allelic landscape by taking advantage of the powerful budding yeast model system. With our recent completion of the whole genome resequencing of over 1,011 natural isolates (http://1002genomes.u-strasbg.fr/), plus the accompanying phenotyping efforts, we have currently one of the best understanding of the natural genetic and phenotypic diversity of any eukaryote model system to date. These datasets will lay the foundation of Phenome'N'al, which aims to dissect the inheritance, expressivity and genetic interactions hidden behind the phenotypic landscape of an entire natural population.

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The information about "PHENOMENAL" are provided by the European Opendata Portal: CORDIS opendata.

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