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PhenomeNal SIGNED

Inheritance, expressivity and epistasis hidden behindthe phenotypic landscape of natural populations

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 PhenomeNal project word cloud

Explore the words cloud of the PhenomeNal project. It provides you a very rough idea of what is the project "PhenomeNal" about.

dissect    plus    phenotyping    causes    little    display    hidden    law    effect    population    genome    marry    date    indicate    yeast    mendel    datasets    model    strasbg    association    deeper    variation    components    011    causal    accompanying    evident    al    backgrounds    populations    natural    hampered    entire    century    advantage    genetic    connect    allelic    expressivity    complete    continuous    throughput    budding    architecture    lack    first    environment    expression    biology    phenotypic    resequencing    epigenetic    observations    inheritance    efforts    completion    landscape    explained    confounded    heritable    altogether    clear    elucidating    shown    variability    http    mutations    resists    traits    diversity    interactions    rediscovery    powerful    1002genomes    awesome    eukaryote    phenome    fr    missing    heritability    generalization    relatively    lay    plan    loci    isolates    variants    concerning    frame    monogenic    genomics    foundation   

Project "PhenomeNal" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITE DE STRASBOURG 

Organization address
address: RUE BLAISE PASCAL 4
city: STRASBOURG
postcode: 67081
website: http://www.unistra.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 1˙999˙882 €
 EC max contribution 1˙999˙882 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-COG
 Funding Scheme ERC-COG
 Starting year 2018
 Duration (year-month-day) from 2018-09-01   to  2023-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITE DE STRASBOURG FR (STRASBOURG) coordinator 1˙999˙882.00

Map

 Project objective

Elucidating the causes of the awesome phenotypic diversity observed in natural populations is a major challenge in biology. It is now clear that the understanding of traits is not only hampered by non-heritable factors such as the environment and epigenetic variation, but also confounded by the lack of complete knowledge concerning the genetic components of traits. More than a century after the rediscovery of Mendel’s law, the genetic architecture of traits still resists generalization. First, this is increasingly evident as shown by recent genome-wide association studies, where identified causal loci explained relatively little of the heritability of most complex traits, leading to the “missing heritability”. Second, we also have recently shown that monogenic mutations can display a significant, variable and continuous phenotypic expression, called expressivity, across different genetic backgrounds. Altogether, these observations clearly indicate that a better understanding of the genetic architecture of traits requires a deeper knowledge of the variability of the phenotypic effect of genetic variants across an entire population. In the frame of the Phenome'N'al project, I plan to marry classical but high-throughput genetic methods with new approaches based on population genomics to connect the phenotypic and allelic landscape by taking advantage of the powerful budding yeast model system. With our recent completion of the whole genome resequencing of over 1,011 natural isolates (http://1002genomes.u-strasbg.fr/), plus the accompanying phenotyping efforts, we have currently one of the best understanding of the natural genetic and phenotypic diversity of any eukaryote model system to date. These datasets will lay the foundation of Phenome'N'al, which aims to dissect the inheritance, expressivity and genetic interactions hidden behind the phenotypic landscape of an entire natural population.

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The information about "PHENOMENAL" are provided by the European Opendata Portal: CORDIS opendata.

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