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PhenomeNal SIGNED

Inheritance, expressivity and epistasis hidden behindthe phenotypic landscape of natural populations

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 PhenomeNal project word cloud

Explore the words cloud of the PhenomeNal project. It provides you a very rough idea of what is the project "PhenomeNal" about.

expression    powerful    expressivity    relatively    environment    date    allelic    dissect    causes    lay    resequencing    eukaryote    traits    causal    elucidating    hampered    biology    mutations    century    shown    deeper    resists    rediscovery    evident    http    first    plan    natural    association    mendel    efforts    little    variability    missing    yeast    clear    hidden    budding    1002genomes    genomics    backgrounds    display    complete    awesome    genome    lack    advantage    datasets    heritable    frame    loci    al    phenotyping    epigenetic    genetic    populations    strasbg    monogenic    foundation    011    components    heritability    interactions    variants    law    inheritance    confounded    fr    indicate    architecture    continuous    completion    diversity    phenome    concerning    explained    altogether    landscape    accompanying    observations    plus    phenotypic    isolates    marry    generalization    variation    entire    effect    model    connect    population    throughput   

Project "PhenomeNal" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITE DE STRASBOURG 

Organization address
address: RUE BLAISE PASCAL 4
city: STRASBOURG
postcode: 67081
website: http://www.unistra.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 1˙999˙882 €
 EC max contribution 1˙999˙882 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-COG
 Funding Scheme ERC-COG
 Starting year 2018
 Duration (year-month-day) from 2018-09-01   to  2023-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITE DE STRASBOURG FR (STRASBOURG) coordinator 1˙999˙882.00

Map

 Project objective

Elucidating the causes of the awesome phenotypic diversity observed in natural populations is a major challenge in biology. It is now clear that the understanding of traits is not only hampered by non-heritable factors such as the environment and epigenetic variation, but also confounded by the lack of complete knowledge concerning the genetic components of traits. More than a century after the rediscovery of Mendel’s law, the genetic architecture of traits still resists generalization. First, this is increasingly evident as shown by recent genome-wide association studies, where identified causal loci explained relatively little of the heritability of most complex traits, leading to the “missing heritability”. Second, we also have recently shown that monogenic mutations can display a significant, variable and continuous phenotypic expression, called expressivity, across different genetic backgrounds. Altogether, these observations clearly indicate that a better understanding of the genetic architecture of traits requires a deeper knowledge of the variability of the phenotypic effect of genetic variants across an entire population. In the frame of the Phenome'N'al project, I plan to marry classical but high-throughput genetic methods with new approaches based on population genomics to connect the phenotypic and allelic landscape by taking advantage of the powerful budding yeast model system. With our recent completion of the whole genome resequencing of over 1,011 natural isolates (http://1002genomes.u-strasbg.fr/), plus the accompanying phenotyping efforts, we have currently one of the best understanding of the natural genetic and phenotypic diversity of any eukaryote model system to date. These datasets will lay the foundation of Phenome'N'al, which aims to dissect the inheritance, expressivity and genetic interactions hidden behind the phenotypic landscape of an entire natural population.

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The information about "PHENOMENAL" are provided by the European Opendata Portal: CORDIS opendata.

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