Explore the words cloud of the HGB-StIC project. It provides you a very rough idea of what is the project "HGB-StIC" about.
The following table provides information about the project.
UNIVERSITAIR MEDISCH CENTRUM UTRECHT
|Coordinator Country||Netherlands [NL]|
|Total cost||260˙929 €|
|EC max contribution||260˙929 € (100%)|
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
|Duration (year-month-day)||from 2019-01-01 to 2021-12-31|
Take a look of project's partnership.
|1||UNIVERSITAIR MEDISCH CENTRUM UTRECHT||NL (UTRECHT)||coordinator||260˙929.00|
|2||THE ROCKEFELLER UNIVERSITY NOT FOR PROFIT CORPORATION||US (NEW YORK)||partner||0.00|
Staphylococcus aureus is one of the most important bacterial pathogens impacting human health. Beta-barrel pore-forming toxins (BB-PFTs) are major virulence factors of S. aureus that destroy phagocytes, key effectors of immunity during staphylococcal infection, in a receptor-specific manner. Acquired immunity to a specific compound of S. aureus, LTA, can rescue an inborn error of the TLR2 pathway (TIRAP deficiency). I hypothesize that severe staphylococcal infections during childhood, at least in some patients, can result from single gene inborn errors of immunity. Some of these disorders may affect immunity to BB-PFTs and the TLR2 pathway. In this project, a cohort of ±70 patients with severe S. aureus infections during childhood will be investigated for mutations responsible for a poor outcome of infection. I will perform whole exome sequencing in these patients and their parents. I will search for mutations in genes encoding BB-PFT-receptors and the TLR2 pathway. I will also search for mutations in a genome-wide approach, testing various genetic models and taking advantage, when appropriate, of genome-wide linkage. I will then functionally characterize the candidate mutations. Depending on the gene identified, a set of experiments will be performed to investigate the functional consequences of the morbid gene on immunity against S. aureus, and I will further characterize the specific host-pathogen interaction. This project will not only shed light on the pathogenesis of S. aureus, but will also provide the basis for new avenues of vaccine and treatment strategies. By investigating human host counterparts in a genome-wide setting, this study is the first unbiased and systematic assessment linking S. aureus virulence factors with host genetic predisposition.
Are you the coordinator (or a participant) of this project? Plaese send me more information about the "HGB-STIC" project.
For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.
Send me an email (email@example.com) and I put them in your project's page as son as possible.
Thanks. And then put a link of this page into your project's website.
The information about "HGB-STIC" are provided by the European Opendata Portal: CORDIS opendata.
Narrative, Writing, and the Teotihuacan Language: Exploring Language History Through Phylogenetics, Epigraphy and IconographyRead More
An integrated hypothesis for cognitive and positive symptoms in schizophreniaRead More
Role of the SWI/SNF complex in the Androgen Receptor cistrome regulationRead More