Explore the words cloud of the TCELLTIGIT project. It provides you a very rough idea of what is the project "TCELLTIGIT" about.
The following table provides information about the project.
THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN
|Coordinator Country||Ireland [IE]|
|Total cost||175˙866 €|
|EC max contribution||175˙866 € (100%)|
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
|Duration (year-month-day)||from 2019-01-01 to 2020-12-31|
Take a look of project's partnership.
|1||THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN||IE (DUBLIN)||coordinator||175˙866.00|
The goal of this proposal is to obtain atomic resolution structures of TIGIT using X-ray crystallography and cryo-electron microscopy. TIGIT inhibits autoimmune responses, and anti-TIGIT antibodies can induce immune response in anti-viral and anti-tumor immunotherapies. No structures exist for the transmembrane (TM) domain of TIGIT, which is the portion of the signaling protein that transmits signals accross the membrane bilayer, and there are no structures of TIGIT bound to anti-TIGIT antibodies. High-resolution structures of full-length TIGIT and TM domain constructs will further our understanding of how TIGIT transmits signals across the cell membrane and modulates T cell activation. Structures of TIGIT TM constructs bound to PVR and anti-TIGIT antibodies will guide the design of anti-TIGIT drugs and antibodies for use in immunotherapy treatments. The candidate will carry out this structural work in the lab of Prof. Martin Caffrey, a world- renowned leader in the field of membrane protein X-ray crystallography.
Are you the coordinator (or a participant) of this project? Plaese send me more information about the "TCELLTIGIT" project.
For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.
Send me an email (firstname.lastname@example.org) and I put them in your project's page as son as possible.
Thanks. And then put a link of this page into your project's website.
The information about "TCELLTIGIT" are provided by the European Opendata Portal: CORDIS opendata.
Narrative, Writing, and the Teotihuacan Language: Exploring Language History Through Phylogenetics, Epigraphy and IconographyRead More
From ecology to neurobiology: spatial cognition in rainforest frogsRead More
Shaping the European Migration Policy: the role of the security industryRead More