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MetalloGutRepair SIGNED

Identification of a Metalloproteinase-17-mediated cellular signalling circuit in intestinal regeneration and tumorigenesis

Total Cost €

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EC-Contrib. €

0

Partnership

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 MetalloGutRepair project word cloud

Explore the words cloud of the MetalloGutRepair project. It provides you a very rough idea of what is the project "MetalloGutRepair" about.

independent    attempt    gastrointestinal    identifies    career    epithelium    biological    absent    preliminary    responsible    regeneration    reveal    culture    skills    differentiate    rid    substrate    cancers    cells    plays    de    environment    disease    candidates    infections    data    visceral    gets    stress    assigned    combines    expertise    repair    niche    repairs    expressed    commensal    water    regulator    injuries    differentiating    host    ex    subpopulation    flora    unbiased    pathogens    researcher    proteins    largely    cleaving    irradiation    experiments    lgr5    mediates    mmp17    metallogutrepair    mmps    constant    co    mechanical    cell    provides    enzymes    organoids    lost    hypothesize    injury    first    caused    smooth    vivo    nutrients    regain    tumorigenesis    stem    spectrometry    models    cellular    matrix    lab    tract    inflammation    mass    intestinal    original    goals    body    muscle    pool    treating    signalling    unknown    model    combine    implications    digestive    play    metalloproteinases    thrive    notably    iscs   

Project "MetalloGutRepair" data sheet

The following table provides information about the project.

Coordinator
NORGES TEKNISK-NATURVITENSKAPELIGE UNIVERSITET NTNU 

Organization address
address: HOGSKOLERINGEN 1
city: TRONDHEIM
postcode: 7491
website: www.ntnu.no

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Norway [NO]
 Total cost 196˙400 €
 EC max contribution 196˙400 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-04-01   to  2020-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    NORGES TEKNISK-NATURVITENSKAPELIGE UNIVERSITET NTNU NO (TRONDHEIM) coordinator 196˙400.00

Map

 Project objective

The digestive tract has been assigned important but complex tasks. It provides our body with nutrients and water. It gets rid of pathogens while allowing the commensal flora to thrive, and it quickly repairs injuries caused by the constant mechanical and biological stress. Lgr5 intestinal stem cells (ISCs) play a crucial role in these processes, but when ISCs are lost due to injury, differentiating cells must ‘de-differentiate’ into ISCs to regain the stem cell pool. The cellular signalling processes that control these repair processes are still largely unknown. Matrix metalloproteinases (MMPs) are enzymes capable of cleaving both matrix and non-matrix proteins. My preliminary data identifies Mmp17 as a crucial regulator of inflammation-induced intestinal regeneration. Notably, Mmp17 is only expressed in a subpopulation of visceral smooth muscle cells, and thus is absent from the epithelium. I hypothesize that Mmp17 cells provide essential niche factors for repair. In addition, I propose that Mmp17 plays an important role in tumorigenesis. First, I will test the role of Mmp17 in intestinal regeneration after whole-body irradiation. My in vivo studies will be supported by an original ex vivo co-culture model, where I combine organoids and muscle cells. Next, I will test the role of Mmp17 in an established tumorigenesis model. Finally, I will attempt to identify the responsible substrate that mediates these processes, both by unbiased mass spectrometry experiments, and by focusing on likely candidates. This work will reveal a new role for muscle cells in the repair of the intestinal epithelium, and may have important implications for treating inflammation, infections and gastrointestinal cancers. MetalloGutRepair thus combines my expertise in smooth muscle cells with that of the host lab in intestinal disease models, in a research environment where I will reach my immediate goals while developing crucial skills for my long-term career as an independent researcher.

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The information about "METALLOGUTREPAIR" are provided by the European Opendata Portal: CORDIS opendata.

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