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MetalloGutRepair SIGNED

Identification of a Metalloproteinase-17-mediated cellular signalling circuit in intestinal regeneration and tumorigenesis

Total Cost €

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EC-Contrib. €

0

Partnership

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 MetalloGutRepair project word cloud

Explore the words cloud of the MetalloGutRepair project. It provides you a very rough idea of what is the project "MetalloGutRepair" about.

candidates    metallogutrepair    independent    play    expressed    mmps    regulator    smooth    original    plays    skills    models    combines    subpopulation    goals    cellular    body    epithelium    constant    repair    researcher    cleaving    substrate    absent    pathogens    provides    metalloproteinases    expertise    cancers    preliminary    flora    host    notably    model    stem    largely    combine    muscle    environment    caused    experiments    nutrients    spectrometry    gastrointestinal    mechanical    repairs    inflammation    identifies    cells    tumorigenesis    differentiating    first    cell    hypothesize    digestive    water    signalling    enzymes    treating    niche    intestinal    rid    visceral    lost    irradiation    vivo    infections    injury    mediates    thrive    assigned    iscs    matrix    unknown    data    reveal    lgr5    injuries    differentiate    implications    unbiased    mass    culture    tract    pool    biological    disease    mmp17    gets    ex    proteins    regeneration    organoids    responsible    stress    regain    commensal    career    co    attempt    de    lab   

Project "MetalloGutRepair" data sheet

The following table provides information about the project.

Coordinator		 NORGES TEKNISK-NATURVITENSKAPELIGE UNIVERSITET NTNU 

Organization address
address: HOGSKOLERINGEN 1
city: TRONDHEIM
postcode: 7491
website: www.ntnu.no

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country Norway [NO]
 Total cost 196˙400 €
 EC max contribution 196˙400 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-04-01   to  2020-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    NORGES TEKNISK-NATURVITENSKAPELIGE UNIVERSITET NTNU NO (TRONDHEIM) coordinator 196˙400.00

Map

 Project objective

The digestive tract has been assigned important but complex tasks. It provides our body with nutrients and water. It gets rid of pathogens while allowing the commensal flora to thrive, and it quickly repairs injuries caused by the constant mechanical and biological stress. Lgr5 intestinal stem cells (ISCs) play a crucial role in these processes, but when ISCs are lost due to injury, differentiating cells must ‘de-differentiate’ into ISCs to regain the stem cell pool. The cellular signalling processes that control these repair processes are still largely unknown. Matrix metalloproteinases (MMPs) are enzymes capable of cleaving both matrix and non-matrix proteins. My preliminary data identifies Mmp17 as a crucial regulator of inflammation-induced intestinal regeneration. Notably, Mmp17 is only expressed in a subpopulation of visceral smooth muscle cells, and thus is absent from the epithelium. I hypothesize that Mmp17 cells provide essential niche factors for repair. In addition, I propose that Mmp17 plays an important role in tumorigenesis. First, I will test the role of Mmp17 in intestinal regeneration after whole-body irradiation. My in vivo studies will be supported by an original ex vivo co-culture model, where I combine organoids and muscle cells. Next, I will test the role of Mmp17 in an established tumorigenesis model. Finally, I will attempt to identify the responsible substrate that mediates these processes, both by unbiased mass spectrometry experiments, and by focusing on likely candidates. This work will reveal a new role for muscle cells in the repair of the intestinal epithelium, and may have important implications for treating inflammation, infections and gastrointestinal cancers. MetalloGutRepair thus combines my expertise in smooth muscle cells with that of the host lab in intestinal disease models, in a research environment where I will reach my immediate goals while developing crucial skills for my long-term career as an independent researcher.

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The information about "METALLOGUTREPAIR" are provided by the European Opendata Portal: CORDIS opendata.

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