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A novel integrative strategy to prevent colorectal cancer within the diet-host-microbiota triangle: from organoids to human in vivo reality

Total Cost €


EC-Contrib. €






 TRIANGLE project word cloud

Explore the words cloud of the TRIANGLE project. It provides you a very rough idea of what is the project "TRIANGLE" about.

microbiome    inoculated    obese    fermented    diet    scenario    immortalized    colonic    context    cell    action    report    nutrition    culture    vital    colon    outcome    assigned    decipher    firstly    metabolically    claims    integrative    assays    tested    tools    life    model    extrapolated    phytochemicals    revealed    prevention    unveil    polyphenols    differ    biological    relationship    deepen    compounds    metabolomics    healthy    cells    donors    recommendations    accounted    constituents    colorectal    cancer    deduced    received    vitro    hints    death    mysteries    anti    batch    host    multiple    rejected    secondly    anticancer    despite    vivo    2d    published    controversy    chemopreventive    lines    efsa    artificially    significantly    mechanisms    proliferative    dietary    nutritional    80    crc    benefits    tumoroids    strategy    feces    apple    afterwards    polyphenol    lean    health    suspected    human    digested    organoids    metabolites    personalized   

Project "TRIANGLE" data sheet

The following table provides information about the project.


Organization address
address: VIA CALEPINA 14
city: TRENTO
postcode: 38122

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 168˙277 €
 EC max contribution 168˙277 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-07-01   to  2020-06-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITA DEGLI STUDI DI TRENTO IT (TRENTO) coordinator 168˙277.00


 Project objective

Colorectal cancer (CRC) is the second cause of death in the EU, and so far, diet has been accounted for up to 80% of the cases. In this context, dietary phytochemicals have received increasing interest due to their suspected role in the prevention of cancer. Numerous studies report the chemopreventive effects of polyphenols. However, health benefits assigned to dietary constituents are still under controversy as can be deduced from the large number of applications rejected by the EFSA (health claims). Despite the crucial role of polyphenols in many biological cases, adequate tools to decipher the relationship between diet-microbiome-host are not yet available. To unveil the mysteries in the emerging field of personalized nutrition, this proposal aims to develop a new in vitro model for the study of phytochemicals in CRC prevention. The most common approach to study the anti-proliferative activity of polyphenols against CRC involves the use of 2D cell lines. Although multiple hints on the possible anticancer effects of these compounds have been already published, these results cannot be extrapolated to human. Firstly, immortalized 2D cell lines differ metabolically from in vivo cells. Secondly, these compounds were not artificially digested and fermented. Therefore, a novel integrative strategy to deepen understanding of CRC is vital. To accomplish this, a real-life scenario is needed. In this context, colon organoids/tumoroids will be established. Afterwards, an apple will be digested/fermented in vitro using a batch culture colonic model inoculated with feces from lean/obese healthy donors. In the end, such polyphenol metabolites will be tested in colon organoids/tumoroids and the mechanisms of action will be revealed by metabolomics and organoids assays. The outcome of this proposal will significantly deepen our knowledge of polyphenols-microbiome-organoids, and, in the long term, will allow nutritional recommendations to be given for the prevention of cancer.

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The information about "TRIANGLE" are provided by the European Opendata Portal: CORDIS opendata.

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