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TRIANGLE SIGNED

A novel integrative strategy to prevent colorectal cancer within the diet-host-microbiota triangle: from organoids to human in vivo reality

Total Cost €

EC-Contrib. €

Partnership

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TRIANGLE project word cloud

Explore the words cloud of the TRIANGLE project. It provides you a very rough idea of what is the project "TRIANGLE" about.

rejected secondly benefits diet revealed claims integrative immortalized polyphenol assigned differ metabolically crc chemopreventive decipher phytochemicals deduced constituents inoculated fermented colon colonic relationship outcome significantly biological action 2d dietary metabolites cells vitro microbiome polyphenols metabolomics deepen feces organoids multiple cell nutritional artificially suspected apple batch context controversy unveil extrapolated donors received anti mysteries host anticancer compounds assays report vivo death mechanisms recommendations tools scenario lines cancer 80 nutrition lean accounted human afterwards efsa digested life health colorectal hints proliferative published model tumoroids healthy culture strategy prevention despite vital tested obese firstly personalized

Project "TRIANGLE" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITA DEGLI STUDI DI TRENTO Organization address address: VIA CALEPINA 14 city: TRENTO postcode: 38122 website: www.unitn.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Italy [IT]
Total cost	168˙277 €
EC max contribution	168˙277 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2017
Funding Scheme	MSCA-IF-EF-ST
Starting year	2018
Duration (year-month-day)	from 2018-07-01 to 2020-06-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITA DEGLI STUDI DI TRENTO UNIVERSITA DEGLI STUDI DI TRENTO Organization address address: VIA CALEPINA 14 city: TRENTO postcode: 38122 website: www.unitn.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (TRENTO)	coordinator	168˙277.00

Map

Project objective

Colorectal cancer (CRC) is the second cause of death in the EU, and so far, diet has been accounted for up to 80% of the cases. In this context, dietary phytochemicals have received increasing interest due to their suspected role in the prevention of cancer. Numerous studies report the chemopreventive effects of polyphenols. However, health benefits assigned to dietary constituents are still under controversy as can be deduced from the large number of applications rejected by the EFSA (health claims). Despite the crucial role of polyphenols in many biological cases, adequate tools to decipher the relationship between diet-microbiome-host are not yet available. To unveil the mysteries in the emerging field of personalized nutrition, this proposal aims to develop a new in vitro model for the study of phytochemicals in CRC prevention. The most common approach to study the anti-proliferative activity of polyphenols against CRC involves the use of 2D cell lines. Although multiple hints on the possible anticancer effects of these compounds have been already published, these results cannot be extrapolated to human. Firstly, immortalized 2D cell lines differ metabolically from in vivo cells. Secondly, these compounds were not artificially digested and fermented. Therefore, a novel integrative strategy to deepen understanding of CRC is vital. To accomplish this, a real-life scenario is needed. In this context, colon organoids/tumoroids will be established. Afterwards, an apple will be digested/fermented in vitro using a batch culture colonic model inoculated with feces from lean/obese healthy donors. In the end, such polyphenol metabolites will be tested in colon organoids/tumoroids and the mechanisms of action will be revealed by metabolomics and organoids assays. The outcome of this proposal will significantly deepen our knowledge of polyphenols-microbiome-organoids, and, in the long term, will allow nutritional recommendations to be given for the prevention of cancer.

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The information about "TRIANGLE" are provided by the European Opendata Portal: CORDIS opendata.