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TRIANGLE SIGNED

A novel integrative strategy to prevent colorectal cancer within the diet-host-microbiota triangle: from organoids to human in vivo reality

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 TRIANGLE project word cloud

Explore the words cloud of the TRIANGLE project. It provides you a very rough idea of what is the project "TRIANGLE" about.

unveil    cell    artificially    prevention    received    crc    deepen    metabolites    tools    tested    relationship    mechanisms    controversy    metabolically    biological    vital    colonic    host    integrative    hints    fermented    culture    dietary    diet    secondly    inoculated    published    despite    anticancer    batch    recommendations    health    life    immortalized    constituents    context    extrapolated    colorectal    phytochemicals    personalized    claims    model    mysteries    assays    compounds    accounted    tumoroids    nutritional    action    differ    digested    vitro    revealed    80    polyphenol    nutrition    cancer    colon    healthy    benefits    obese    efsa    afterwards    outcome    firstly    decipher    assigned    strategy    microbiome    metabolomics    human    suspected    report    rejected    proliferative    lines    scenario    vivo    deduced    donors    multiple    anti    organoids    lean    cells    2d    feces    apple    significantly    polyphenols    chemopreventive    death   

Project "TRIANGLE" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITA DEGLI STUDI DI TRENTO 

Organization address
address: VIA CALEPINA 14
city: TRENTO
postcode: 38122
website: www.unitn.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 168˙277 €
 EC max contribution 168˙277 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-07-01   to  2020-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITA DEGLI STUDI DI TRENTO IT (TRENTO) coordinator 168˙277.00

Map

 Project objective

Colorectal cancer (CRC) is the second cause of death in the EU, and so far, diet has been accounted for up to 80% of the cases. In this context, dietary phytochemicals have received increasing interest due to their suspected role in the prevention of cancer. Numerous studies report the chemopreventive effects of polyphenols. However, health benefits assigned to dietary constituents are still under controversy as can be deduced from the large number of applications rejected by the EFSA (health claims). Despite the crucial role of polyphenols in many biological cases, adequate tools to decipher the relationship between diet-microbiome-host are not yet available. To unveil the mysteries in the emerging field of personalized nutrition, this proposal aims to develop a new in vitro model for the study of phytochemicals in CRC prevention. The most common approach to study the anti-proliferative activity of polyphenols against CRC involves the use of 2D cell lines. Although multiple hints on the possible anticancer effects of these compounds have been already published, these results cannot be extrapolated to human. Firstly, immortalized 2D cell lines differ metabolically from in vivo cells. Secondly, these compounds were not artificially digested and fermented. Therefore, a novel integrative strategy to deepen understanding of CRC is vital. To accomplish this, a real-life scenario is needed. In this context, colon organoids/tumoroids will be established. Afterwards, an apple will be digested/fermented in vitro using a batch culture colonic model inoculated with feces from lean/obese healthy donors. In the end, such polyphenol metabolites will be tested in colon organoids/tumoroids and the mechanisms of action will be revealed by metabolomics and organoids assays. The outcome of this proposal will significantly deepen our knowledge of polyphenols-microbiome-organoids, and, in the long term, will allow nutritional recommendations to be given for the prevention of cancer.

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The information about "TRIANGLE" are provided by the European Opendata Portal: CORDIS opendata.

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