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O6-alkylguanines SIGNED

Characterisation and quantification of O6-alkylguanine DNA adducts derived from nitrosated amino acids: Risk factors in colorectal cancer.

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 O6-alkylguanines project word cloud

Explore the words cloud of the O6-alkylguanines project. It provides you a very rough idea of what is the project "O6-alkylguanines" about.

variety    exposure    alkylating    levels    adducts    dietary    reactive    agents    individuals    risk    base    dna    cancer    o6   

Project "O6-alkylguanines" data sheet

The following table provides information about the project.

Coordinator
THE UNIVERSITY OF SHEFFIELD 

Organization address
address: FIRTH COURT WESTERN BANK
city: SHEFFIELD
postcode: S10 2TN
website: www.shef.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
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 Coordinator Country United Kingdom [UK]
 Total cost 195˙454 €
 EC max contribution 195˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme /MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-05-01   to  2021-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF SHEFFIELD UK (SHEFFIELD) coordinator 195˙454.00

Mappa

 Project objective

The exposure of DNA to alkylating agents can produce base adducts such as O6-alkylguanines, that if not repaired, can lead to a variety of effects including toxicity, mutagenicity and cancer. Although exposure may be significant for certain individuals such as workers in the chemical industry and smokers, all individuals are exposed to alkylating agents from dietary components or that derive from reactive intermediates formed endogenously. For example, nitrosation of dietary amines, amino acids and their derivatives can produce reactive alkylating agents that can result in the formation of a variety of DNA base adducts. One such adduct, O6-carboxymethylguanine (O6-CMG) has been directly correlated to dietary levels of red meat, a known risk factor for developing colorectal cancer, the second most common cancer in Europe. This proposal will use novel synthetic oligodeoxyribonucleotide (ODN) and nucleoside standards to develop highly sensitive mass spectrometry-based analytical methods to identify and quantify levels of specific O6-alkylguanine adducts in DNA. This methodology will enable links to be made between exposure and cancer risk, lead to the identification of novel predictive biomarkers and benefit the assessment of human health at both the individual and population level, paving the way for more informative monitoring studies.

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