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O6-alkylguanines TERMINATED

Characterisation and quantification of O6-alkylguanine DNA adducts derived from nitrosated amino acids: Risk factors in colorectal cancer.

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 O6-alkylguanines project word cloud

Explore the words cloud of the O6-alkylguanines project. It provides you a very rough idea of what is the project "O6-alkylguanines" about.

alkylguanine    nucleoside    agents    components    cmg    quantify    spectrometry    levels    workers    identification    chemical    cancer    dietary    monitoring    certain    endogenously    repaired    paving    acids    colorectal    individuals    individual    meat    standards    methodology    amino    formed    odn    alkylating    smokers    exposed    amines    base    analytical    red    oligodeoxyribonucleotide    alkylguanines    human    correlated    adducts    nitrosation    synthetic    benefit    informative    health    dna    made    derive    derivatives    toxicity    mutagenicity    exposure    risk    intermediates    carboxymethylguanine    industry    links    o6    variety    population    sensitive    biomarkers    adduct    predictive    reactive    mass   

Project "O6-alkylguanines" data sheet

The following table provides information about the project.

Coordinator	THE UNIVERSITY OF SHEFFIELD    more Organization address address: FIRTH COURT WESTERN BANK city: SHEFFIELD postcode: S10 2TN website: www.shef.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Total cost	195˙454 €
EC max contribution	195˙454 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2017
Funding Scheme	MSCA-IF-EF-ST
Starting year	2019
Duration (year-month-day)	from 2019-05-01   to  2021-04-30

 Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	THE UNIVERSITY OF SHEFFIELD × THE UNIVERSITY OF SHEFFIELD Organization address address: FIRTH COURT WESTERN BANK city: SHEFFIELD postcode: S10 2TN website: www.shef.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a. Close	UK (SHEFFIELD)	coordinator	195˙454.00

Map

 Project objective

The exposure of DNA to alkylating agents can produce base adducts such as O6-alkylguanines, that if not repaired, can lead to a variety of effects including toxicity, mutagenicity and cancer. Although exposure may be significant for certain individuals such as workers in the chemical industry and smokers, all individuals are exposed to alkylating agents from dietary components or that derive from reactive intermediates formed endogenously. For example, nitrosation of dietary amines, amino acids and their derivatives can produce reactive alkylating agents that can result in the formation of a variety of DNA base adducts. One such adduct, O6-carboxymethylguanine (O6-CMG) has been directly correlated to dietary levels of red meat, a known risk factor for developing colorectal cancer, the second most common cancer in Europe. This proposal will use novel synthetic oligodeoxyribonucleotide (ODN) and nucleoside standards to develop highly sensitive mass spectrometry-based analytical methods to identify and quantify levels of specific O6-alkylguanine adducts in DNA. This methodology will enable links to be made between exposure and cancer risk, lead to the identification of novel predictive biomarkers and benefit the assessment of human health at both the individual and population level, paving the way for more informative monitoring studies.

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The information about "O6-ALKYLGUANINES" are provided by the European Opendata Portal: CORDIS opendata.

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