Explore the words cloud of the PNECtumor project. It provides you a very rough idea of what is the project "PNECtumor" about.
The following table provides information about the project.
KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW
|Coordinator Country||Netherlands [NL]|
|Total cost||177˙598 €|
|EC max contribution||177˙598 € (100%)|
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
|Duration (year-month-day)||from 2019-01-01 to 2020-12-31|
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|1||KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW||NL (AMSTERDAM)||coordinator||177˙598.00|
The ultimate goal of my research is to elucidate pathways involved in lung neuroendocrine tumor (LNET) formation. LNETs arise from a rare lung cell population, called pulmonary neuroendocrine cells (PNECs) and account for 20- to 25% of all lung cancers. Despite their involvement in LNETs and a number of other respiratory diseases, relatively little is known about the normal function of PNECs or their contribution to cancer development and progression. Utilizing a novel organoid based strategy for in vitro isolation and analysis of PNECs, I will develop a model of LNE tumorigenesis with a focus on two LNET subtypes, small cell lung cancer (SCLC) and atypical carcinoids (AC). Altogether, the experiments outlined in this proposal are focused on the functional characterization of PNECs and the elucidation of the pathways involved in the transformation of this cell type during LNET formation.
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The information about "PNECTUMOR" are provided by the European Opendata Portal: CORDIS opendata.