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MyoChip SIGNED

Building a 3D innervated and irrigated muscle on a chip.

Total Cost €

EC-Contrib. €

Partnership

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MyoChip project word cloud

Explore the words cloud of the MyoChip project. It provides you a very rough idea of what is the project "MyoChip" about.

team prime vitro skeletal biorobotics mathematical irrigated shape myochip joins physiologic vivo network contractility feasibility interdisciplinary screening foundations muscle reconstituted irrigation aging building engineers limited function prosthetics push vasculature regenerative mirror relies engineering candidate neurons 3d drug tackle modellers experts additional methodological motor biologists human lay generation innervation innervated found architecture material chip pertinence organ vascular microenvironment tissue organs cell microfluidics

Project "MyoChip" data sheet

The following table provides information about the project.

Coordinator	INSTITUTO DE MEDICINA MOLECULAR JOAO LOBO ANTUNES Organization address address: AVENIDA PROF EGAS MONIZ city: LISBOA postcode: 1649 028 website: www.imm.ul.pt contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Portugal [PT]
Total cost	3˙153˙553 €
EC max contribution	3˙153˙553 € (100%)
Programme	1. H2020-EU.1.2.1. (FET Open)
Code Call	H2020-FETOPEN-1-2016-2017
Funding Scheme	RIA
Starting year	2018
Duration (year-month-day)	from 2018-11-01 to 2022-10-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	INSTITUTO DE MEDICINA MOLECULAR JOAO LOBO ANTUNES INSTITUTO DE MEDICINA MOLECULAR JOAO LOBO ANTUNES Organization address address: AVENIDA PROF EGAS MONIZ city: LISBOA postcode: 1649 028 website: www.imm.ul.pt contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	PT (LISBOA)	coordinator	1˙266˙861.00
2	INSTITUT CURIE INSTITUT CURIE Organization address address: rue d'Ulm 26 city: PARIS postcode: 75231 website: www.curie.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	participant	668˙054.00
3	THE UNIVERSITY OF EDINBURGH THE UNIVERSITY OF EDINBURGH Organization address address: OLD COLLEGE, SOUTH BRIDGE city: EDINBURGH postcode: EH8 9YL website: www.ed.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (EDINBURGH)	participant	610˙172.00
4	FLUIGENT SA FLUIGENT SA Organization address address: 57-77 AVENUE DE FONTAINEBLEAU city: LE KREMLIN-BICETRE postcode: 94270 website: www.fluigent.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (LE KREMLIN-BICETRE)	participant	608˙465.00

Map

Project objective

The aim of the MyoChip project is to build a 3D human skeletal muscle irrigated by vasculature and innervated by neurons. The reconstituted 3D muscle will mirror the architecture and function found in vivo, namely in shape, contractility and microenvironment, while irrigation by a vascular network and innervation by human motor neurons will bring additional physiologic pertinence to it. This organ-on-a-chip technology will have numerous applications including but not limited to research on muscle building and aging, drug testing and screening, as well as prosthetics and biorobotics. The feasibility of the project relies on the interdisciplinary approach which joins a team of cell biologists, material engineers, experts in microfluidics and mathematical modellers. The architecture of skeletal muscle and its regenerative capabilities make muscle a prime candidate to push the 3D tissue engineering field. As such the project will lay the technical, material and methodological foundations to tackle the next generation of complex organ-on-a-chip systems that the MyoChip consortium can exploit for the generation of highly complex 3D in vitro systems of many organs.

Deliverables

List of deliverables.
Data Management Plan	Open Research Data Pilot	2020-02-12 16:55:13
Design of multi-tubular microchannels	Demonstrators, pilots, prototypes	2020-02-12 16:55:23
Gene editing method	Demonstrators, pilots, prototypes	2020-02-12 16:55:09
Project website and logo	Websites, patent fillings, videos etc.	2020-02-12 16:55:12

Take a look to the deliverables list in detail: detailed list of MyoChip deliverables.

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The information about "MYOCHIP" are provided by the European Opendata Portal: CORDIS opendata.