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SHIKIFACTORY100 SIGNED

Modular cell factories for the production of 100 compounds from the shikimate pathway

Total Cost €

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EC-Contrib. €

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Partnership

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Project "SHIKIFACTORY100" data sheet

The following table provides information about the project.

Coordinator
SILICOLIFE LDA 

Organization address
address: RUA DO CANASTREIRO 15
city: BRAGA
postcode: 4715 387
website: www.silicolife.com

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Portugal [PT]
 Total cost 7˙995˙343 €
 EC max contribution 7˙995˙343 € (100%)
 Programme 1. H2020-EU.2.1.4. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies – Biotechnology)
 Code Call H2020-NMBP-BIO-2018-two-stage
 Funding Scheme RIA
 Starting year 2019
 Duration (year-month-day) from 2019-01-01   to  2023-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    SILICOLIFE LDA PT (BRAGA) coordinator 1˙091˙125.00
2    THE UNIVERSITY OF MANCHESTER UK (MANCHESTER) participant 1˙030˙016.00
3    DANMARKS TEKNISKE UNIVERSITET DK (KGS LYNGBY) participant 988˙000.00
4    UNIVERSIDADE NOVA DE LISBOA PT (LISBOA) participant 899˙950.00
5    DSM FOOD SPECIALTIES BV NL (DELFT) participant 885˙000.00
6    EUROPEAN MOLECULAR BIOLOGY LABORATORY DE (HEIDELBERG) participant 792˙650.00
7    ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE CH (LAUSANNE) participant 700˙838.00
8    GALCHIMIA SA ES (O PINO A CORUNA) participant 495˙241.00
9    C-LECTA GMBH DE (LEIPZIG) participant 400˙900.00
10    The National Non-Food Crops Centre UK (YORK) participant 360˙500.00
11    UNIVERSIDADE DO MINHO PT (BRAGA) participant 351˙122.00

Map

 Project objective

Chemical synthesis is often difficult and may be subject to unclear mechanisms, frequently producing undesired by-products, while the complexity of some compounds may rendered them virtually unattainable. Nature can provide a wealth of products, however typically at very low concentrations, which makes their extraction process expensive. Conversely, microbial production is a well-established process for compounds naturally produced by the hosts or for which there are fully characterised biosynthetic pathways. However, relying on nature’s diversity as a provider for industrial applications typically requires major screenings for pathways, genes and optimisation of cell factories for the efficient production of the target compounds. SHIKIFACTORY100 project aims towards the production of a universe of more than 100 high-added value compounds from the shikimate pathway, a hub in cell metabolism, through the development of an optimised shikimate chassis) and the proposal and implementation of novel biosynthetic routes exploring enzyme promiscuity to propose new pathways for the production of known and newly designed compounds. To champion SHIKIFACTORY100 project a consortium with some of the most relevant players in Europe has been assembled, covering research leading institutions in computational design, rapid prototyping and in vivo implementation of pathways and cell factories. As such, six world-leading research partners, four biotechnology SMEs with complementary focus areas and one large industrial company have been integrated. The research partners will be responsible for novel methods for pathway discovery and compound design, collaborating with the SMEs in the implementation and optimisation of the chassis, while SMEs and industrial partners will lead the assessment of the products and the exploitation of the results for different application areas. The industrial partner will be responsible for the validation of the production.

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The information about "SHIKIFACTORY100" are provided by the European Opendata Portal: CORDIS opendata.

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