Explore the words cloud of the MIX-UP project. It provides you a very rough idea of what is the project "MIX-UP" about.
The following table provides information about the project.
RHEINISCH-WESTFAELISCHE TECHNISCHE HOCHSCHULE AACHEN
|Coordinator Country||Germany [DE]|
|Total cost||7˙365˙335 €|
|EC max contribution||5˙465˙335 € (74%)|
1. H2020-EU.2.1.4. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies – Biotechnology)
|Duration (year-month-day)||from 2020-01-01 to 2023-12-31|
Take a look of project's partnership.
|1||RHEINISCH-WESTFAELISCHE TECHNISCHE HOCHSCHULE AACHEN||DE (AACHEN)||coordinator||1˙927˙796.00|
|2||AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS||ES (MADRID)||participant||780˙838.00|
|3||UNIVERSITAET GREIFSWALD||DE (GREIFSWALD)||participant||720˙638.00|
|4||BIOPLASTECH LTD||IE (DUBLIN)||participant||521˙882.00|
|5||UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN||IE (DUBLIN)||participant||509˙955.00|
|6||CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS||FR (PARIS)||participant||417˙922.00|
|7||FORSCHUNGSZENTRUM JULICH GMBH||DE (JULICH)||participant||314˙426.00|
|8||AB Enzymes GmbH||DE (Darmstadt)||participant||158˙750.00|
|9||PGS PACIFIC GARBAGE SCREENING GMBH||DE (AACHEN)||participant||62˙625.00|
The continuing demand for plastic products, the lack of appropriate recycling and the ubiquitous pollution of the environment with plastic waste pose a global challenge. An ambitious vision and considerable efforts are required to change the traditional value chain of plastics to a sustainable one, based on biodegradable plastics. In MIX-UP, plastic mixtures with five of the top six fossil-based recalcitrant plastics (PP, PE, PUR, PET, and PS), along with upcoming biodegradable plastics such as PLA and PHA, will be used as feedstock for microbial transformations, thereby generating a workflow that increases the recycling quota and adds value to poorly recycled plastics waste streams. Successive controlled enzymatic and microbial degradation of mechanically pre-treated plastics waste will be combined with subsequent microbial conversion to value-added chemicals and polymers by mixed cultures. We will optimize known plastics-degrading enzymes for high specific binding capacities, stability, and catalytic efficacy towards a broad spectrum of plastics polymers under high salt and temperature conditions by integrated protein engineering, and also isolate novel enzymes with activities on recalcitrant polymers. MIX-UP will also optimize the production of enzymes and formulate enzyme cocktails tailored to specific waste streams. Implementation of these enzymes, both in vitro and in vivo, enables stable self-sustaining microbiomes to convert the released plastic monomers selectively into at least six value-added products, key building blocks, and biomass. Any remaining material recalcitrant to enzymatic activity will be recirculated into the process after a physico-chemical treatment. The Chinese-European MIX-UP is a multidisciplinary and industry-driven consortium that addresses the market need for novel sustainable routes to valorise plastics waste streams. MIX-UP realises a circular (bio)-economy and could be a viable alternative for mechanical and chemical recycling.
|year||authors and title||journal||last update|
Wing-Jin Li, Tanja Narancic, Shane T. Kenny, Paul-Joachim Niehoff, Kevin Oâ€™Connor, Lars M. Blank, Nick Wierckx
Unraveling 1,4-Butanediol Metabolism in Pseudomonas putida KT2440
published pages: , ISSN: 1664-302X, DOI: 10.3389/fmicb.2020.00382
|Frontiers in Microbiology 11||2020-04-15|
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