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3DBIOLUNG SIGNED

Bioengineering lung tissue using extracellular matrix based 3D bioprinting

Total Cost €

0

EC-Contrib. €

0

Partnership

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 3DBIOLUNG project word cloud

Explore the words cloud of the 3DBIOLUNG project. It provides you a very rough idea of what is the project "3DBIOLUNG" about.

manufacturing    transplants    demonstrating    annually    scalable    combining    options    disease    innovative    xenogeneic    angiogenesis    transplantation    prior    tissues    lung    anatomical    stage    differences    awaiting    hybrid    feasibility    biologically    science    diseases    bioengineering    seeded    generate    cues    architecture    prevalence    chronic    option    conductive    scaffolds    printing    obviating    bioreactor    65    bioprint    printed    lack    1000    biological    materials    worldwide    desperately    3d    indicate    custom    fiction    ideally    sources    first    tissue    reproducibility    regeneration    immunosuppression    area    cells    engineering    critical    transplant    models    gas    generating    mimicking    functional    bioprinters    primary    ex    once    heterogeneity    4000    difficulty    mature    recipient    patients    vivo    human    receive    thought    grown    patient    acellular    constructs    reproducible    synthetic    murine    bioprinting    million    immune    exchange   

Project "3DBIOLUNG" data sheet

The following table provides information about the project.

Coordinator
LUNDS UNIVERSITET 

Organization address
address: Paradisgatan 5c
city: LUND
postcode: 22100
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Sweden [SE]
 Total cost 1˙499˙975 €
 EC max contribution 1˙499˙975 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-01-01   to  2023-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    LUNDS UNIVERSITET SE (LUND) coordinator 1˙499˙975.00

Map

 Project objective

Chronic lung diseases are increasing in prevalence with over 65 million patients worldwide. Lung transplantation remains the only potential option at end-stage disease. Around 4000 patients receive lung transplants annually with more awaiting transplantation, including 1000 patients in Europe. New options to increase available tissue for lung transplantation are desperately needed.

An exciting new research area focuses on generating lung tissue ex vivo using bioengineering approaches. Scaffolds can be generated from synthetic or biologically-derived (acellular) materials, seeded with cells and grown in a bioreactor prior to transplantation. Ideally, scaffolds would be seeded with cells derived from the transplant recipient, thus obviating the need for long-term immunosuppression. However, functional regeneration has yet to be achieved. New advances in 3D printing and 3D bioprinting (when cells are printed) indicate that this once thought of science-fiction concept might finally be mature enough for complex tissues, including lung. 3D bioprinting addresses a number of concerns identified in previous approaches, such as a) patient heterogeneity in acellular human scaffolds, b) anatomical differences in xenogeneic sources, c) lack of biological cues on synthetic materials and d) difficulty in manufacturing the complex lung architecture. 3D bioprinting could be a reproducible, scalable, and controllable approach for generating functional lung tissue.

The aim of this proposal is to use custom 3D bioprinters to generate constructs mimicking lung tissue using an innovative approach combining primary cells, the engineering reproducibility of synthetic materials, and the biologically conductive properties of acellular lung (hybrid). We will 3D bioprint hybrid murine and human lung tissue models and test gas exchange, angiogenesis and in vivo immune responses. This proposal will be a critical first step in demonstrating feasibility of 3D bioprinting lung tissue.

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The information about "3DBIOLUNG" are provided by the European Opendata Portal: CORDIS opendata.

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