ProDAP SIGNED
Protein Dynamics in Antiviral Processes
Total Cost €
0EC-Contrib. €
0Partnership
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0ProDAP project word cloud
Explore the words cloud of the ProDAP project. It provides you a very rough idea of what is the project "ProDAP" about.
Project "ProDAP" data sheet
The following table provides information about the project.
| Coordinator |
TECHNISCHE UNIVERSITAET MUENCHEN
Organization address contact info |
| Coordinator Country | Germany [DE] |
| Total cost | 2˙169˙555 € |
| EC max contribution | 2˙169˙555 € (100%) |
| Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
| Code Call | ERC-2018-COG |
| Funding Scheme | ERC-COG |
| Starting year | 2019 |
| Duration (year-month-day) | from 2019-04-01 to 2024-03-31 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | TECHNISCHE UNIVERSITAET MUENCHEN | DE (MUENCHEN) | coordinator | 2˙169˙555.00 |
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Project objective
The innate antiviral defense system is of central importance to protect from viral pathogens. Its ability to mitigate a detrimental outcome of an infectious event relies on interactions that happen between viral and host-derived proteins as well as on signalling cascades that regulate the cellular response. However, despite the importance of these interactions, the involved processes and proteins are not yet fully understood.
We established state of the art mass spectrometry techniques and statistical modelling to characterise protein-protein interactions that are affected by viruses. We identified a class of proteins we name “viral affected proteins changing their interaction” (iVAPs). In addition, we established protein turnover rates of >6900 proteins in virus infected cells and identified a group of “viral affected proteins changing turnover rates” (tVAPs). tVAPs are regulated on basis of protein stabilisation, degradation or translation. Preliminary experiments show critical importance of iVAPs and tVAPs in antiviral immunity, suggesting functional similarities to Interferon stimulated genes (ISGs). Alike ISGs, VAPs therefore represent a critical component of the immune system.
ProDAP will establish the function of iVAPs and tVAPs in the antiviral immune response. Systematic screens employing depletion and overexpression experiments, integration of these data in functional networks and mechanistic follow up studies will be performed. Already identified and new candidate proteins will be tested mechanistically for their immune-regulatory capacity and their influence on virus infections in vitro and in vivo.
ProDAP will allow insights in yet unstudied modulators of host-pathogen interplay and will influence our current understanding of immune regulation in general. It is well established that ISGs are of central importance to defend virus infections and we hypothesize that VAPs may fulfil a similarly important protective function that has yet not been elucid
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