Opendata, web and dolomites

ProDAP SIGNED

Protein Dynamics in Antiviral Processes

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 ProDAP project word cloud

Explore the words cloud of the ProDAP project. It provides you a very rough idea of what is the project "ProDAP" about.

elucid    outcome    hypothesize    protein    virus    interactions    viral    stimulated    mechanistically    regulated    signalling    isgs    integration    pathogens    central    name    host    cells    stabilisation    spectrometry    vaps    statistical    tvaps    function    modulators    interaction    mass    event    despite    employing    cascades    vivo    happen    tested    vitro    infections    proteins    gt    data    immune    relies    class    defense    interferon    techniques    antiviral    systematic    detrimental    capacity    mechanistic    genes    experiments    alike    mitigate    innate    prodap    group    translation    characterise    functional    6900    defend    similarities    ivaps    infected    regulate    similarly    suggesting    regulatory    insights    cellular    protect    preliminary    protective    degradation    immunity    changing    overexpression    unstudied    performed    fulfil    screens    influence    basis    interplay    follow    rates    turnover    viruses    regulation    networks    critical    infectious    depletion    pathogen    candidate   

Project "ProDAP" data sheet

The following table provides information about the project.

Coordinator
TECHNISCHE UNIVERSITAET MUENCHEN 

Organization address
address: Arcisstrasse 21
city: MUENCHEN
postcode: 80333
website: www.tu-muenchen.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 2˙169˙555 €
 EC max contribution 2˙169˙555 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-COG
 Funding Scheme ERC-COG
 Starting year 2019
 Duration (year-month-day) from 2019-04-01   to  2024-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    TECHNISCHE UNIVERSITAET MUENCHEN DE (MUENCHEN) coordinator 2˙169˙555.00

Map

 Project objective

The innate antiviral defense system is of central importance to protect from viral pathogens. Its ability to mitigate a detrimental outcome of an infectious event relies on interactions that happen between viral and host-derived proteins as well as on signalling cascades that regulate the cellular response. However, despite the importance of these interactions, the involved processes and proteins are not yet fully understood.

We established state of the art mass spectrometry techniques and statistical modelling to characterise protein-protein interactions that are affected by viruses. We identified a class of proteins we name “viral affected proteins changing their interaction” (iVAPs). In addition, we established protein turnover rates of >6900 proteins in virus infected cells and identified a group of “viral affected proteins changing turnover rates” (tVAPs). tVAPs are regulated on basis of protein stabilisation, degradation or translation. Preliminary experiments show critical importance of iVAPs and tVAPs in antiviral immunity, suggesting functional similarities to Interferon stimulated genes (ISGs). Alike ISGs, VAPs therefore represent a critical component of the immune system.

ProDAP will establish the function of iVAPs and tVAPs in the antiviral immune response. Systematic screens employing depletion and overexpression experiments, integration of these data in functional networks and mechanistic follow up studies will be performed. Already identified and new candidate proteins will be tested mechanistically for their immune-regulatory capacity and their influence on virus infections in vitro and in vivo.

ProDAP will allow insights in yet unstudied modulators of host-pathogen interplay and will influence our current understanding of immune regulation in general. It is well established that ISGs are of central importance to defend virus infections and we hypothesize that VAPs may fulfil a similarly important protective function that has yet not been elucid

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "PRODAP" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "PRODAP" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

Aware (2019)

Aiding Antibiotic Development with Deep Analysis of Resistance Evolution

Read More  

Resonances (2019)

Resonances and Zeta Functions in Smooth Ergodic Theory and Geometry

Read More  

TERIFIC (2018)

Targeted Experiment to Reconcile Increased Freshwater with Increased Convection

Read More