Opendata, web and dolomites

ProDAP SIGNED

Protein Dynamics in Antiviral Processes

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 ProDAP project word cloud

Explore the words cloud of the ProDAP project. It provides you a very rough idea of what is the project "ProDAP" about.

viral    degradation    spectrometry    tested    name    antiviral    systematic    screens    6900    techniques    interaction    vitro    mechanistically    capacity    cells    protect    hypothesize    protein    functional    rates    group    depletion    regulate    genes    regulatory    basis    modulators    despite    suggesting    class    mechanistic    pathogen    vivo    isgs    unstudied    viruses    relies    mass    immune    alike    follow    preliminary    characterise    infectious    stabilisation    defend    mitigate    integration    translation    virus    infected    similarly    pathogens    interferon    performed    fulfil    cellular    central    proteins    ivaps    elucid    turnover    insights    regulation    changing    signalling    employing    critical    overexpression    interactions    stimulated    regulated    outcome    innate    host    networks    happen    cascades    prodap    data    tvaps    detrimental    defense    influence    vaps    gt    infections    function    similarities    experiments    event    immunity    candidate    interplay    statistical    protective   

Project "ProDAP" data sheet

The following table provides information about the project.

Coordinator
TECHNISCHE UNIVERSITAET MUENCHEN 

Organization address
address: Arcisstrasse 21
city: MUENCHEN
postcode: 80333
website: www.tu-muenchen.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 2˙169˙555 €
 EC max contribution 2˙169˙555 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-COG
 Funding Scheme ERC-COG
 Starting year 2019
 Duration (year-month-day) from 2019-04-01   to  2024-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    TECHNISCHE UNIVERSITAET MUENCHEN DE (MUENCHEN) coordinator 2˙169˙555.00

Map

 Project objective

The innate antiviral defense system is of central importance to protect from viral pathogens. Its ability to mitigate a detrimental outcome of an infectious event relies on interactions that happen between viral and host-derived proteins as well as on signalling cascades that regulate the cellular response. However, despite the importance of these interactions, the involved processes and proteins are not yet fully understood.

We established state of the art mass spectrometry techniques and statistical modelling to characterise protein-protein interactions that are affected by viruses. We identified a class of proteins we name “viral affected proteins changing their interaction” (iVAPs). In addition, we established protein turnover rates of >6900 proteins in virus infected cells and identified a group of “viral affected proteins changing turnover rates” (tVAPs). tVAPs are regulated on basis of protein stabilisation, degradation or translation. Preliminary experiments show critical importance of iVAPs and tVAPs in antiviral immunity, suggesting functional similarities to Interferon stimulated genes (ISGs). Alike ISGs, VAPs therefore represent a critical component of the immune system.

ProDAP will establish the function of iVAPs and tVAPs in the antiviral immune response. Systematic screens employing depletion and overexpression experiments, integration of these data in functional networks and mechanistic follow up studies will be performed. Already identified and new candidate proteins will be tested mechanistically for their immune-regulatory capacity and their influence on virus infections in vitro and in vivo.

ProDAP will allow insights in yet unstudied modulators of host-pathogen interplay and will influence our current understanding of immune regulation in general. It is well established that ISGs are of central importance to defend virus infections and we hypothesize that VAPs may fulfil a similarly important protective function that has yet not been elucid

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "PRODAP" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "PRODAP" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

Resonances (2019)

Resonances and Zeta Functions in Smooth Ergodic Theory and Geometry

Read More  

TAMING CORROSION (2020)

Towards mastering the long-standing challenge of ageing infrastructures in corrosive environments

Read More  

Aware (2019)

Aiding Antibiotic Development with Deep Analysis of Resistance Evolution

Read More