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ProDAP SIGNED

Protein Dynamics in Antiviral Processes

Total Cost €

0

EC-Contrib. €

0

Partnership

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 ProDAP project word cloud

Explore the words cloud of the ProDAP project. It provides you a very rough idea of what is the project "ProDAP" about.

modulators    outcome    pathogens    event    elucid    interferon    defend    characterise    antiviral    preliminary    follow    interaction    employing    signalling    gt    regulate    infected    immunity    isgs    mass    candidate    viral    techniques    despite    tvaps    similarities    pathogen    unstudied    genes    cellular    ivaps    integration    experiments    changing    influence    vaps    regulatory    protect    virus    spectrometry    screens    regulated    vivo    proteins    defense    regulation    cells    performed    stimulated    viruses    prodap    networks    cascades    stabilisation    similarly    group    interactions    immune    vitro    mitigate    turnover    interplay    functional    translation    mechanistically    systematic    rates    tested    name    protective    mechanistic    statistical    relies    host    depletion    basis    happen    protein    infections    fulfil    critical    alike    insights    function    class    capacity    detrimental    infectious    suggesting    degradation    hypothesize    innate    overexpression    data    central    6900   

Project "ProDAP" data sheet

The following table provides information about the project.

Coordinator
TECHNISCHE UNIVERSITAET MUENCHEN 

Organization address
address: Arcisstrasse 21
city: MUENCHEN
postcode: 80333
website: www.tu-muenchen.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 2˙169˙555 €
 EC max contribution 2˙169˙555 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-COG
 Funding Scheme ERC-COG
 Starting year 2019
 Duration (year-month-day) from 2019-04-01   to  2024-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    TECHNISCHE UNIVERSITAET MUENCHEN DE (MUENCHEN) coordinator 2˙169˙555.00

Map

 Project objective

The innate antiviral defense system is of central importance to protect from viral pathogens. Its ability to mitigate a detrimental outcome of an infectious event relies on interactions that happen between viral and host-derived proteins as well as on signalling cascades that regulate the cellular response. However, despite the importance of these interactions, the involved processes and proteins are not yet fully understood.

We established state of the art mass spectrometry techniques and statistical modelling to characterise protein-protein interactions that are affected by viruses. We identified a class of proteins we name “viral affected proteins changing their interaction” (iVAPs). In addition, we established protein turnover rates of >6900 proteins in virus infected cells and identified a group of “viral affected proteins changing turnover rates” (tVAPs). tVAPs are regulated on basis of protein stabilisation, degradation or translation. Preliminary experiments show critical importance of iVAPs and tVAPs in antiviral immunity, suggesting functional similarities to Interferon stimulated genes (ISGs). Alike ISGs, VAPs therefore represent a critical component of the immune system.

ProDAP will establish the function of iVAPs and tVAPs in the antiviral immune response. Systematic screens employing depletion and overexpression experiments, integration of these data in functional networks and mechanistic follow up studies will be performed. Already identified and new candidate proteins will be tested mechanistically for their immune-regulatory capacity and their influence on virus infections in vitro and in vivo.

ProDAP will allow insights in yet unstudied modulators of host-pathogen interplay and will influence our current understanding of immune regulation in general. It is well established that ISGs are of central importance to defend virus infections and we hypothesize that VAPs may fulfil a similarly important protective function that has yet not been elucid

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