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SkinTrmDeep SIGNED

Tissue Resident Memory (Trm) CD8+ T cells: Genome-wide dissection of cellular differentiation and heterogeneity

Total Cost €

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EC-Contrib. €

0

Partnership

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 SkinTrmDeep project word cloud

Explore the words cloud of the SkinTrmDeep project. It provides you a very rough idea of what is the project "SkinTrmDeep" about.

coupled    critical    interactions    biology    imprinting    ultimate    protection    memory    population    host    samples    goals    illuminate    populations    cell    skin    unprecedented    single    cells    sorting    identification    ontogeny    gut    eliciting    cytometry    organs    function    multidisciplinary    binding    surfaces    rely    patient    functionally    unravel    producing    throughput    basis    career    functions    cytokine    lungs    capacity    cytotoxic    epigenetic    scientist    generating    diverse    circulating    human    understand    immunity    denominators    differentiation    sequencing    mechanisms    immunotherapies    lymphoid    comprising    lymphocyte    profiles    am    pathology    molecular    diseases    determined    forefront    resident    pathogens    resolution    localized    flow    framework    tissue    barrier    predominant    limited    tissues    decipher    microenvironment    residency    cd8    rna    poorly    effector    collaborations    young    encompassing    map    phenotypically    potentially    shaping    cellular    trm    unravelling    immune    integral    regulatory    mounting    transcription    chromatin    promise    lymphocytes    independent    accessibility    heterogeneity    genome   

Project "SkinTrmDeep" data sheet

The following table provides information about the project.

Coordinator
KAROLINSKA INSTITUTET 

Organization address
address: Nobels Vag 5
city: STOCKHOLM
postcode: 17177
website: www.ki.se

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Sweden [SE]
 Total cost 173˙857 €
 EC max contribution 173˙857 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-03-01   to  2021-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KAROLINSKA INSTITUTET SE (STOCKHOLM) coordinator 173˙857.00

Map

 Project objective

Tissue-resident memory (Trm) cells are non-circulating T lymphocytes of non-lymphoid tissues and organs that provide localized protection at barrier surfaces such as skin, gut and lungs. In human skin, Trm cells represent the predominant lymphocyte population, comprising subsets with different cytokine profiles and cytotoxic capacity. They represent an integral part of barrier immunity, mounting tailored responses to diverse pathogens, but potentially also eliciting immune pathology. Trm cell differentiation, effector mechanisms and cellular interactions remain poorly defined. I aim to decipher cytotoxic Trm cell biology in greater depth, unravelling the epigenetic framework of phenotypically and functionally distinct CD8 Trm populations. I will rely on state-of-the-art methodologies at the host institution. Through unique collaborations and a multidisciplinary approach encompassing advanced flow cytometry, cell sorting and high-throughput sequencing, I propose to map genome-wide chromatin accessibility in skin and gut Trm cell subsets. Identification of regulatory elements critical for cell functions coupled with analyses of transcription factor binding promise to unravel the molecular mechanisms defining Trm cell ontogeny, function and tissue-specific imprinting. Moreover, with potential application to limited patient samples, single-cell RNA sequencing of cytokine-producing cells will provide a map of Trm cell heterogeneity with unprecedented resolution. This project will illuminate the role of the microenvironment in shaping tissue-resident memory, with ultimate goals to understand Trm cell-related diseases and determine common denominators required to establish tissue residency and provide basis for generating and shaping Trm cells in future cellular immunotherapies. Being at the forefront of the research on the epigenetic differentiation processes of lymphocytes, I am determined to build a strong basis for a future career as a young independent scientist.

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The information about "SKINTRMDEEP" are provided by the European Opendata Portal: CORDIS opendata.

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