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SkinTrmDeep SIGNED

Tissue Resident Memory (Trm) CD8+ T cells: Genome-wide dissection of cellular differentiation and heterogeneity

Total Cost €

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EC-Contrib. €

0

Partnership

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 SkinTrmDeep project word cloud

Explore the words cloud of the SkinTrmDeep project. It provides you a very rough idea of what is the project "SkinTrmDeep" about.

human    functions    resident    resolution    single    host    rely    epigenetic    potentially    cells    capacity    am    protection    unravelling    accessibility    pathogens    barrier    cytometry    cell    eliciting    comprising    limited    lymphoid    mounting    interactions    goals    identification    denominators    binding    unprecedented    regulatory    patient    unravel    producing    mechanisms    effector    chromatin    throughput    localized    trm    shaping    multidisciplinary    organs    immunity    pathology    lymphocyte    function    imprinting    flow    cd8    young    rna    skin    scientist    generating    functionally    immune    illuminate    lungs    biology    tissue    immunotherapies    predominant    transcription    decipher    independent    lymphocytes    tissues    sorting    gut    encompassing    microenvironment    circulating    molecular    populations    cellular    poorly    differentiation    surfaces    career    samples    heterogeneity    diverse    residency    diseases    coupled    ultimate    cytotoxic    critical    determined    population    promise    integral    profiles    understand    sequencing    cytokine    memory    ontogeny    map    phenotypically    forefront    framework    basis    collaborations    genome   

Project "SkinTrmDeep" data sheet

The following table provides information about the project.

Coordinator
KAROLINSKA INSTITUTET 

Organization address
address: Nobels Vag 5
city: STOCKHOLM
postcode: 17177
website: www.ki.se

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Sweden [SE]
 Total cost 173˙857 €
 EC max contribution 173˙857 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-03-01   to  2021-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KAROLINSKA INSTITUTET SE (STOCKHOLM) coordinator 173˙857.00

Map

 Project objective

Tissue-resident memory (Trm) cells are non-circulating T lymphocytes of non-lymphoid tissues and organs that provide localized protection at barrier surfaces such as skin, gut and lungs. In human skin, Trm cells represent the predominant lymphocyte population, comprising subsets with different cytokine profiles and cytotoxic capacity. They represent an integral part of barrier immunity, mounting tailored responses to diverse pathogens, but potentially also eliciting immune pathology. Trm cell differentiation, effector mechanisms and cellular interactions remain poorly defined. I aim to decipher cytotoxic Trm cell biology in greater depth, unravelling the epigenetic framework of phenotypically and functionally distinct CD8 Trm populations. I will rely on state-of-the-art methodologies at the host institution. Through unique collaborations and a multidisciplinary approach encompassing advanced flow cytometry, cell sorting and high-throughput sequencing, I propose to map genome-wide chromatin accessibility in skin and gut Trm cell subsets. Identification of regulatory elements critical for cell functions coupled with analyses of transcription factor binding promise to unravel the molecular mechanisms defining Trm cell ontogeny, function and tissue-specific imprinting. Moreover, with potential application to limited patient samples, single-cell RNA sequencing of cytokine-producing cells will provide a map of Trm cell heterogeneity with unprecedented resolution. This project will illuminate the role of the microenvironment in shaping tissue-resident memory, with ultimate goals to understand Trm cell-related diseases and determine common denominators required to establish tissue residency and provide basis for generating and shaping Trm cells in future cellular immunotherapies. Being at the forefront of the research on the epigenetic differentiation processes of lymphocytes, I am determined to build a strong basis for a future career as a young independent scientist.

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The information about "SKINTRMDEEP" are provided by the European Opendata Portal: CORDIS opendata.

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