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RNAflashbacks SIGNED

The Neuronal Code of Inheritance

Total Cost €

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EC-Contrib. €

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Partnership

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Project "RNAflashbacks" data sheet

The following table provides information about the project.

Coordinator
TEL AVIV UNIVERSITY 

Organization address
address: RAMAT AVIV
city: TEL AVIV
postcode: 69978
website: http://www.tau.ac.il/

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Israel [IL]
 Total cost 2˙000˙000 €
 EC max contribution 2˙000˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-COG
 Funding Scheme ERC-COG
 Starting year 2019
 Duration (year-month-day) from 2019-08-01   to  2024-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    TEL AVIV UNIVERSITY IL (TEL AVIV) coordinator 2˙000˙000.00

Map

 Project objective

Little is known about non-DNA mediated transgenerational inheritance of parental responses. If inheritance of non-genetic materials is prevalent, it could challenge our conceptions regarding the rules and limits of heredity. We are in particularly intrigued by the possibility that the nervous system can produce heritable changes. Mechanisms for propagation of responses from the soma to the germline are known. Until very recently, the possibility that any type of environmental response could become heritable, let alone somatic responses, was considered blasphemous. In C. elegans nematodes, exogenously-supplied artificial dsRNA transfers from the soma to the germline, triggering transgenerational small RNA-mediated RNA interference. It is unknown whether endogenous small RNAs can transmit specific information about the environment to the progeny. We will investigate if endogenous siRNAs, which are naturally made in somatic tissues, and in particular in neurons, produce transgenerational responses. Specifically, we will test which RNA molecules act transgenerationally, how do they mediate non-cell autonomous gene regulation, and which responses can be communicated to the progeny. What is the code that transforms particular environmental responses to specific arsenals of heritable RNA molecules? We will answer these questions, and moreover study the implications that this completely new form of hereditary has for the offspring’s survival. Can heritable small RNAs retain adaptive memory? Not only will we elucidate natural transmission of the parents’ activity from generation-to-generation, we will moreover devise means to control these mechanisms. We will engineer tools to diagnose, erase, maintain, and modulate the heritable effects, which would be important for basic research and hopefully also translational in the future.

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The information about "RNAFLASHBACKS" are provided by the European Opendata Portal: CORDIS opendata.

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