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scTALLmap SIGNED

Single-cell map of the composition and evolution of T-cell acute lymphoblastic leukemia

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 scTALLmap project word cloud

Explore the words cloud of the scTALLmap project. It provides you a very rough idea of what is the project "scTALLmap" about.

diagnosis    overview    subclones    siesta    membership    genome    samples    acute    extensive    stereotypes    vivo    misleading    therapy    resolution    cancer    skills    aggressive    realtime    first    generate    intratumoral    ultimately    map    love    sensitivity    tremendously    transcriptome    personalized    nowadays    heterogeneity    opportunity    clinical    computational    underlying    temporal    relapse    sausages    tumors    envision    incomplete    ex    treatment    judging    expertise    composition    permit    population    subtype    unprecedented    accumulate    profiling    modalities    sparing    cellular    drug    children    sctallmap    shows    germans    genetic    therapeutic    perform    subclonal    pediatric    era    lab    single    spaniards    toxicity    sequencing    stratification    mix    experimental    risk    complement    exquisite    host    paving    leukemia    heterogeneous    beer    technologies    individual    lymphoblastic    daily    full    belgians    cell    carefully    integrative   

Project "scTALLmap" data sheet

The following table provides information about the project.

Coordinator
VIB VZW 

Organization address
address: RIJVISSCHESTRAAT 120
city: ZWIJNAARDE - GENT
postcode: 9052
website: www.vib.be

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Belgium [BE]
 Total cost 178˙320 €
 EC max contribution 178˙320 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-04-01   to  2021-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    VIB VZW BE (ZWIJNAARDE - GENT) coordinator 178˙320.00

Map

 Project objective

Spaniards have their daily siesta, Germans like sausages and Belgians love beer. Stereotypes can certainly be misleading, just like judging a cell by its membership to a particular cell type, the so-called population-based analysis. Nowadays we know that tumors are tremendously heterogeneous and, in the era of single-cell sequencing, we have the exquisite opportunity to study each individual cell with unprecedented resolution. Acute lymphoblastic leukemia (ALL), which is the most common cancer in children, shows extensive genetic intratumoral heterogeneity. This heterogeneity might be the underlying reason for an incomplete response to treatment and for the development of relapse. In order to envision its clinical implementation, it is essential to first i) generate a single-cell map and ii) accumulate evidence on how the subclonal composition affects the response to treatment. With this aim, I will build a comprehensive single-cell overview of the composition, development and response to therapy for the aggressive subtype T-cell ALL. I will perform integrative single-cell genome and transcriptome profiling of ex vivo carefully selected pediatric samples at diagnosis, during drug treatment and in case of relapse. This approach will provide realtime temporal information about the sensitivity of each cell type to the therapy and about how relapse can develop. I will use state-of-the-art single-cell technologies to which the host institute has early access. Moreover, I will apply my previous single-cell expertise and bring a unique mix of experimental and computational skills to the lab. The results of scTALLmap, will have significant impact in leukemia by paving the way for improved risk-stratification based on the cellular heterogeneity and the presence of high-risk subclones at diagnosis. Ultimately, it will permit the design of novel and more personalized therapeutic modalities sparing toxicity and targeting the full complement of leukemia subclones.

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The information about "SCTALLMAP" are provided by the European Opendata Portal: CORDIS opendata.

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