Opendata, web and dolomites

ESX-4 T7SS SIGNED

Structure/function of a prototypic type VII secretion system from a fast-growing pathogenic mycobacteria

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 ESX-4 T7SS project word cloud

Explore the words cloud of the ESX-4 T7SS project. It provides you a very rough idea of what is the project "ESX-4 T7SS" about.

mechanism    macrophages    deemed    genetics    awaited    functional    complementary    mtb    attractive    structural    virulence    function    resolution    investigation    13    eagerly    collaborators    cell    rendering    ecce4    survival    modeling    protein    membrane    recognition    eccb    data    infections    secretion    lack    diverse    dalton    eccc    esx    date    infection    mycobacteria    published    crosses    biology    integrative    multiple    active    responsible    tuberculosis    interdisciplinary    holo    questions    shown    abscessus    substrate    clinically    acquired    microbiology    ancestral    substrates    combine    extrapulmonary    multiply    survive    esx4    communities    mediated    structure    aring    multidrug    sgm    central    ecce    mab    inactive    rgm    functionally    resistant    opportunistic    tuberculous    intact    intracellular    form    components    possess    unlike    pulmonary    except    slow    eccd    mycobacterium    experimental    characterization    host    experiments    inner    lab    t7ss    mycp   

Project "ESX-4 T7SS" data sheet

The following table provides information about the project.

Coordinator
EUROPEAN MOLECULAR BIOLOGY LABORATORY 

Organization address
address: Meyerhofstrasse 1
city: HEIDELBERG
postcode: 69117
website: http://www.embl.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 162˙806 €
 EC max contribution 162˙806 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-04-01   to  2021-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    EUROPEAN MOLECULAR BIOLOGY LABORATORY DE (HEIDELBERG) coordinator 162˙806.00

Map

 Project objective

Mycobacterium abscessus (Mab) is an opportunistic-multidrug-resistant non-tuberculous mycobacteria responsible for multiple clinically-acquired infections both pulmonary and extrapulmonary. Unlike many rapidly growing mycobacteria (RGM), Mab is able to survive and multiply within macrophages, similar to slow growing mycobacteria (SGM) such as M. tuberculosis (Mtb). In Mtb, five T7SS (ESX-1-5) have been identified and shown to be essential for intracellular survival (ESX-1), virulence (ESX-1 and ESX-5) or growth (ESX-3). T7SS are composed of five protein components essential for function: EccB, EccC, EccD, EccE and MycP. Except for a low-resolution structure of the holo ESX-5 complex from the host lab at 13 Å resolution, no structural data on any T7SS have been published to date, rendering structural work timely and eagerly awaited by relevant communities. Deemed inactive due to its lack of one of the established T7SS components EccE4, ESX-4 has been considered an ancestral T7SS form. However, Mab possess a fully intact and functional ESX-4, essential for its intracellular survival, rendering it a highly attractive target for an in-depth characterization. Here, I propose an interdisciplinary project that includes both functional and structural investigation. As the 2 M Dalton-holo-complex crosses the Mab inner membrane, experimental structural work will be challenging and require an integrative modeling approach to combine diverse experimental data sets. Complementary infection biology experiments including microbiology, genetics and cell biology will be carried out by collaborators. With this work, I aim to respond to central questions related to T7SS in general and Mab ESX-4 specifically, such as: what is the mechanism of T7SS-mediated secretion? What makes ESX-4 specific and different from other T7SS? What is the specific role of EccE4 to establish a functionally active ESX4? and What are the substrates and specific mechanism of ESX-4 substrate recognition?

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "ESX-4 T7SS" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "ESX-4 T7SS" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

CoCoNat (2019)

Coordination in constrained and natural distributed systems

Read More  

EVOMET (2019)

The rise and fall of metastatic clones under immune attack

Read More  

Mel.Photo.Protect (2019)

Unraveling the Photoprotecting Mechanism of Melanin - From a Library of Fragments to Simulation of Spectra and Function

Read More