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ImmunoMECH SIGNED

High-performance biomechanical model of combined immunotherapy and anti-angiogenic cancer treatment

Total Cost €

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EC-Contrib. €

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Partnership

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 ImmunoMECH project word cloud

Explore the words cloud of the ImmunoMECH project. It provides you a very rough idea of what is the project "ImmunoMECH" about.

dramatically    shrinkage    perfused    fluid    vasculature    explains    treat    complement    medicines    hypoxic    interstitial    metastatic    networks    invasive    space    immune    evade    professional    tumors    vessel    collaborations    therapies    patients    hinder    sustained    inefficient    host    exhibit    therapeutic    procedure    immunotherapeutic    solid    normalization    expertise    artificial    fail    strategy    numerical    perfusion    drugs    experimentally    immunotherapy    though    optimal    gaining    supply    microenvironment    survival    openings    validate    permeability    cells    combined    receiving    clinical    reduce    rendering    structure    flow    efficacy    performance    international    vascular    vessels    oxygenation    cancer    negatively    hypo    hyper    hypothesize    eradicate    algorithms    standard    training    leaving    abnormalities    systemic    chemo    cellular    skills    tumor    causes    patient    hypoxia    potent    types    subset    drug    treatment    repair    neural    optimization    impaired    interendothelial    molecular    experimental    model    computing    maturity    permeable    blood   

Project "ImmunoMECH" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY OF CYPRUS 

Organization address
address: KALLIPOLEOS STREET 75
city: NICOSIA
postcode: 1678
website: www.ucy.ac.cy

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Cyprus [CY]
 Total cost 145˙941 €
 EC max contribution 145˙941 € (100%)
 Programme 1. H2020-EU.4. (SPREADING EXCELLENCE AND WIDENING PARTICIPATION)
 Code Call H2020-WF-01-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-06-17   to  2021-06-16

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY OF CYPRUS CY (NICOSIA) coordinator 145˙941.00

Map

 Project objective

Inefficient delivery of cellular and molecular medicines to solid tumors can reduce dramatically the efficacy of treatment and affect negatively patient’s survival. This explains in large part why standard chemo- and immune-therapies often fail to treat specific cancer types, even though these therapies are potent enough to eradicate cancer cells. Abnormalities in the structure of the tumor vasculature hinder tumor perfusion and as a result the systemic delivery of the medicines. In many tumor types, blood vessels are hyper-permeable, leaving large interendothelial openings, which causes fluid loss from the vascular to the interstitial tumor space. Vessel hyper-permeability can reduce tumor blood flow, rendering tumors hypo-perfused and hypoxic. Impaired blood supply and hypoxia help cancer cells evade the immune system and increase their invasive and metastatic potential. Normalization of the tumor vasculature is a clinical strategy to repair vascular abnormalities in order to improve perfusion, oxygenation and delivery of medicines. Immunotherapy is gaining interest as an effective therapeutic approach against cancer, but only a subset of patients receiving immunotherapy exhibit sustained tumor shrinkage. Here, we hypothesize that vascular normalization can improve immunotherapy. The objective of the proposed research is the optimal design of the combined immunotherapy and vascular normalization therapeutic approach. To this end, a numerical and experimental study is proposed to model and experimentally validate the vascular normalization procedure, focusing on its combined effects with immunotherapeutic drugs. The proposed research/training will complement the Applicant’s skills in high-performance computing, advanced optimization algorithms and artificial neural networks with the Host’s expertise in tumor microenvironment and cancer drug delivery to enhance his professional maturity and promote international collaborations.

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The information about "IMMUNOMECH" are provided by the European Opendata Portal: CORDIS opendata.

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