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ImmunoMECH SIGNED

High-performance biomechanical model of combined immunotherapy and anti-angiogenic cancer treatment

Total Cost €

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EC-Contrib. €

0

Partnership

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 ImmunoMECH project word cloud

Explore the words cloud of the ImmunoMECH project. It provides you a very rough idea of what is the project "ImmunoMECH" about.

host    hypoxic    professional    metastatic    negatively    hinder    evade    normalization    efficacy    interendothelial    treat    computing    rendering    vessel    fluid    international    interstitial    strategy    types    oxygenation    training    combined    procedure    perfusion    experimentally    molecular    cellular    vascular    tumors    hypo    performance    clinical    collaborations    cancer    tumor    structure    immunotherapeutic    treatment    subset    causes    drugs    space    optimal    algorithms    patients    inefficient    supply    experimental    optimization    fail    potent    permeability    vasculature    survival    hyper    complement    validate    immune    though    sustained    dramatically    artificial    neural    standard    receiving    networks    solid    therapeutic    exhibit    shrinkage    reduce    impaired    patient    medicines    chemo    openings    maturity    vessels    cells    permeable    hypothesize    gaining    microenvironment    abnormalities    model    drug    invasive    repair    blood    expertise    perfused    leaving    numerical    skills    systemic    flow    hypoxia    explains    immunotherapy    therapies    eradicate   

Project "ImmunoMECH" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY OF CYPRUS 

Organization address
address: KALLIPOLEOS STREET 75
city: NICOSIA
postcode: 1678
website: www.ucy.ac.cy

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Cyprus [CY]
 Total cost 145˙941 €
 EC max contribution 145˙941 € (100%)
 Programme 1. H2020-EU.4. (SPREADING EXCELLENCE AND WIDENING PARTICIPATION)
 Code Call H2020-WF-01-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-06-17   to  2021-06-16

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY OF CYPRUS CY (NICOSIA) coordinator 145˙941.00

Map

 Project objective

Inefficient delivery of cellular and molecular medicines to solid tumors can reduce dramatically the efficacy of treatment and affect negatively patient’s survival. This explains in large part why standard chemo- and immune-therapies often fail to treat specific cancer types, even though these therapies are potent enough to eradicate cancer cells. Abnormalities in the structure of the tumor vasculature hinder tumor perfusion and as a result the systemic delivery of the medicines. In many tumor types, blood vessels are hyper-permeable, leaving large interendothelial openings, which causes fluid loss from the vascular to the interstitial tumor space. Vessel hyper-permeability can reduce tumor blood flow, rendering tumors hypo-perfused and hypoxic. Impaired blood supply and hypoxia help cancer cells evade the immune system and increase their invasive and metastatic potential. Normalization of the tumor vasculature is a clinical strategy to repair vascular abnormalities in order to improve perfusion, oxygenation and delivery of medicines. Immunotherapy is gaining interest as an effective therapeutic approach against cancer, but only a subset of patients receiving immunotherapy exhibit sustained tumor shrinkage. Here, we hypothesize that vascular normalization can improve immunotherapy. The objective of the proposed research is the optimal design of the combined immunotherapy and vascular normalization therapeutic approach. To this end, a numerical and experimental study is proposed to model and experimentally validate the vascular normalization procedure, focusing on its combined effects with immunotherapeutic drugs. The proposed research/training will complement the Applicant’s skills in high-performance computing, advanced optimization algorithms and artificial neural networks with the Host’s expertise in tumor microenvironment and cancer drug delivery to enhance his professional maturity and promote international collaborations.

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The information about "IMMUNOMECH" are provided by the European Opendata Portal: CORDIS opendata.

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