Opendata, web and dolomites

MetAeAvIm SIGNED

The Role of the Metabolism in Mosquito Immunity against Dengue virus in Aedes aegypti

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

Project "MetAeAvIm" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 184˙707 €
 EC max contribution 184˙707 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-05-01   to  2021-10-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 184˙707.00

Map

 Project objective

Mosquito-borne diseases remain among the most prevalent diseases in the world with. At present, more than half of the world population lives in areas where mosquito vectors are present. Vector control is one of the cornerstones of arbovirus control. However, insecticide-resistant population are emerging demanding new tools of vector control to be developed. It is known that mosquito immunity can be modulated by its physiological state and nutritional status. However, we still lack an integrated view of how immune mechanisms and metabolic pathways interact to control viruses at different stages of infection. In order to obtain a more detailed understanding of the gene expression profile associated with immunity to Dengue virus (DENV), we performed a genome-wide analysis of the transcriptome of susceptible and resistant individuals from the same population of mosquitoes. Metabolic pathways represented the majority of the differentially expressed gene sets identified by our analysis, suggesting that differences in metabolism determine DENV resistance. These results support the hypothesis that mosquito metabolism plays a key role in controlling mosquito susceptibility to viral infections. In this project, we will characterize the metabolism of mosquitoes and characterize pathways and genes that are determinants for DENV resistance. We will study the metabolism of A. aegypti, comparing susceptible and resistant mosquitoes, measuring specific metabolic outputs and also performing unbiased high-throughput metabolomic studies. In parallel, we will perform reverse genetic screenings to validate whether metabolic pathways and biological processes identified in our transcriptomic analysis have a role in vector competence to DENV. Finally, we will apply the CRISPR/Cas9 technology and classical transgenesis to target genes and pathways that affect vector competence in mosquitoes. Together, this project will allow for a deeper mechanistic study of mosquito antiviral immunity.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "METAEAVIM" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "METAEAVIM" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

NaWaTL (2020)

Narrative, Writing, and the Teotihuacan Language: Exploring Language History Through Phylogenetics, Epigraphy and Iconography

Read More  

MingleIFT (2020)

Multi-color and single-molecule fluorescence imaging of intraflagellar transport in the phasmid chemosensory cilia of C. Elegans

Read More  

MathematicsAnalogies (2019)

Mathematics Analogies

Read More