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CAR-OAC SIGNED

Carotid-artery-on-a-chip device to model thromboembolisms induced by vascular lesions and perform drug screenings

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 CAR-OAC project word cloud

Explore the words cloud of the CAR-OAC project. It provides you a very rough idea of what is the project "CAR-OAC" about.

lipids    elvesys    biological    vascular    avail    inducing    designing    developers    blood    extra    pharmaceutical    intravascular    live    equipped    coagulation    physical    tested    whereas    public    liquids    internal    flow    stroke    experiments    visualization    dimensions    lumen    tias    master    ip    researcher    clinicians    stretching    resolution    physiologically    illustrated    actions    rheological    marketing    engage    diameter    stretch    composition    intended    tissue    tia    engagement    haemodynamics    mechanically    conducting    pathology    varied    erythrocytes    transient    device    subjected    exposure    proximal    thickness    7mm    agents    death    mechanics    cranial    occlusions    artery    strokes    explore    inflammatory    carotid    microscopy    thrombosis    biologically    enriching    globally    applicable    modulated    mimetic    mm    microfluidic    visualize    shear    platelets    solutions    attacks    confocal    environment    pressure    associations    designed    fibrinogen    patenting    ischaemic    therapeutic    trigger    arteries   

Project "CAR-OAC" data sheet

The following table provides information about the project.

Coordinator		 ELVESYS 

Organization address
address: 1-3 BIS RUE ROBERT ET SONIA DELAUNAY
city: PARIS
postcode: 75011
website: www.elvesys.com

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country France [FR]
 Total cost 196˙707 €
 EC max contribution 196˙707 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-SE
 Starting year 2020
 Duration (year-month-day) from 2020-02-17   to  2022-02-16

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ELVESYS FR (PARIS) coordinator 196˙707.00

Map

 Project objective

This project will be focused on designing a microfluidic device to visualize haemodynamics within a carotid-artery mimetic device. The system will be designed to evaluate associations especially between fibrinogen, erythrocytes, and platelets when subjected to shear and coagulation-inducing factors. The design will include biologically and mechanically variable properties as may occur in transient ischaemic attacks (TIA). The intended system is to have similar composition and dimensions as the extra-cranial (common to internal) carotid arteries. Physiologically relevant dimensions will be implemented where the common artery will have a lumen diameter of 6.1 mm with variable thickness (0.6 to 0.9 mm), whereas the internal artery will be 4.7 mm in diameter with thickness of 0.7mm. The system will be equipped with pressure and stretch-inducing mechanics which can be modulated to trigger rheological and biological responses. Specifically, stretching will cause exposure of tissue factor and lipids, capable of triggering inflammatory coagulation. The proximal formation of biological or physical occlusions will be assessed using this device. Also, the design will enable visualization of intra-vascular activity as may be illustrated in live high-resolution confocal microscopy. Flow properties of liquids with varied rheological properties similar to blood will be tested. Clinicians and researchers studying the pathology of strokes and TIAs or conducting studies on intravascular thrombosis will be able to engage this device in experiments while pharmaceutical developers will be able to engage the device in testing actions of therapeutic agents. Stroke remains the second leading cause of death globally and through the development of this device, both developers and potential users of the device will be able to explore effective and applicable solutions. Elvesys will avail the researcher an enriching environment to master IP, marketing concepts, patenting and public engagement.

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The information about "CAR-OAC" are provided by the European Opendata Portal: CORDIS opendata.

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