Opendata, web and dolomites

CAR-OAC SIGNED

Carotid-artery-on-a-chip device to model thromboembolisms induced by vascular lesions and perform drug screenings

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 CAR-OAC project word cloud

Explore the words cloud of the CAR-OAC project. It provides you a very rough idea of what is the project "CAR-OAC" about.

mm    exposure    7mm    clinicians    pressure    engage    designed    environment    mimetic    ip    biological    globally    equipped    death    intravascular    trigger    blood    lipids    strokes    pathology    thrombosis    tissue    extra    visualize    erythrocytes    modulated    physical    device    ischaemic    subjected    internal    carotid    live    flow    developers    stretching    tested    agents    conducting    microscopy    enriching    tias    lumen    experiments    proximal    inducing    coagulation    platelets    researcher    occlusions    biologically    vascular    artery    haemodynamics    stretch    actions    engagement    mechanics    designing    microfluidic    intended    varied    physiologically    inflammatory    arteries    attacks    fibrinogen    elvesys    associations    stroke    marketing    cranial    composition    whereas    pharmaceutical    dimensions    thickness    explore    public    therapeutic    master    diameter    shear    mechanically    tia    solutions    applicable    visualization    transient    illustrated    liquids    resolution    patenting    rheological    confocal    avail   

Project "CAR-OAC" data sheet

The following table provides information about the project.

Coordinator
ELVESYS 

Organization address
address: 1-3 BIS RUE ROBERT ET SONIA DELAUNAY
city: PARIS
postcode: 75011
website: www.elvesys.com

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 196˙707 €
 EC max contribution 196˙707 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-SE
 Starting year 2020
 Duration (year-month-day) from 2020-02-17   to  2022-02-16

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ELVESYS FR (PARIS) coordinator 196˙707.00

Map

 Project objective

This project will be focused on designing a microfluidic device to visualize haemodynamics within a carotid-artery mimetic device. The system will be designed to evaluate associations especially between fibrinogen, erythrocytes, and platelets when subjected to shear and coagulation-inducing factors. The design will include biologically and mechanically variable properties as may occur in transient ischaemic attacks (TIA). The intended system is to have similar composition and dimensions as the extra-cranial (common to internal) carotid arteries. Physiologically relevant dimensions will be implemented where the common artery will have a lumen diameter of 6.1 mm with variable thickness (0.6 to 0.9 mm), whereas the internal artery will be 4.7 mm in diameter with thickness of 0.7mm. The system will be equipped with pressure and stretch-inducing mechanics which can be modulated to trigger rheological and biological responses. Specifically, stretching will cause exposure of tissue factor and lipids, capable of triggering inflammatory coagulation. The proximal formation of biological or physical occlusions will be assessed using this device. Also, the design will enable visualization of intra-vascular activity as may be illustrated in live high-resolution confocal microscopy. Flow properties of liquids with varied rheological properties similar to blood will be tested. Clinicians and researchers studying the pathology of strokes and TIAs or conducting studies on intravascular thrombosis will be able to engage this device in experiments while pharmaceutical developers will be able to engage the device in testing actions of therapeutic agents. Stroke remains the second leading cause of death globally and through the development of this device, both developers and potential users of the device will be able to explore effective and applicable solutions. Elvesys will avail the researcher an enriching environment to master IP, marketing concepts, patenting and public engagement.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "CAR-OAC" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "CAR-OAC" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

CoCoNat (2019)

Coordination in constrained and natural distributed systems

Read More  

EVOMET (2019)

The rise and fall of metastatic clones under immune attack

Read More  

Cartesian Networks (2020)

Cartesian Networks in Early Modern Europe: A Quantitative and Interdisciplinary Approach

Read More