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CAR-OAC SIGNED

Carotid-artery-on-a-chip device to model thromboembolisms induced by vascular lesions and perform drug screenings

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 CAR-OAC project word cloud

Explore the words cloud of the CAR-OAC project. It provides you a very rough idea of what is the project "CAR-OAC" about.

associations    cranial    tia    erythrocytes    biological    therapeutic    stretching    mm    composition    engagement    rheological    confocal    lumen    actions    internal    flow    patenting    dimensions    pharmaceutical    modulated    attacks    death    intravascular    elvesys    coagulation    device    inflammatory    artery    varied    stretch    clinicians    haemodynamics    proximal    ip    mechanically    conducting    resolution    intended    lipids    master    blood    engage    carotid    occlusions    stroke    microfluidic    whereas    tested    designing    equipped    physiologically    thrombosis    fibrinogen    mimetic    developers    transient    ischaemic    solutions    avail    diameter    marketing    inducing    subjected    designed    public    enriching    researcher    tias    globally    visualization    applicable    biologically    pathology    environment    pressure    extra    strokes    arteries    illustrated    7mm    exposure    visualize    agents    live    mechanics    trigger    tissue    shear    experiments    thickness    explore    vascular    physical    microscopy    liquids    platelets   

Project "CAR-OAC" data sheet

The following table provides information about the project.

Coordinator		 ELVESYS 

Organization address
address: 1-3 BIS RUE ROBERT ET SONIA DELAUNAY
city: PARIS
postcode: 75011
website: www.elvesys.com

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country France [FR]
 Total cost 196˙707 €
 EC max contribution 196˙707 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-SE
 Starting year 2020
 Duration (year-month-day) from 2020-02-17   to  2022-02-16

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ELVESYS FR (PARIS) coordinator 196˙707.00

Map

 Project objective

This project will be focused on designing a microfluidic device to visualize haemodynamics within a carotid-artery mimetic device. The system will be designed to evaluate associations especially between fibrinogen, erythrocytes, and platelets when subjected to shear and coagulation-inducing factors. The design will include biologically and mechanically variable properties as may occur in transient ischaemic attacks (TIA). The intended system is to have similar composition and dimensions as the extra-cranial (common to internal) carotid arteries. Physiologically relevant dimensions will be implemented where the common artery will have a lumen diameter of 6.1 mm with variable thickness (0.6 to 0.9 mm), whereas the internal artery will be 4.7 mm in diameter with thickness of 0.7mm. The system will be equipped with pressure and stretch-inducing mechanics which can be modulated to trigger rheological and biological responses. Specifically, stretching will cause exposure of tissue factor and lipids, capable of triggering inflammatory coagulation. The proximal formation of biological or physical occlusions will be assessed using this device. Also, the design will enable visualization of intra-vascular activity as may be illustrated in live high-resolution confocal microscopy. Flow properties of liquids with varied rheological properties similar to blood will be tested. Clinicians and researchers studying the pathology of strokes and TIAs or conducting studies on intravascular thrombosis will be able to engage this device in experiments while pharmaceutical developers will be able to engage the device in testing actions of therapeutic agents. Stroke remains the second leading cause of death globally and through the development of this device, both developers and potential users of the device will be able to explore effective and applicable solutions. Elvesys will avail the researcher an enriching environment to master IP, marketing concepts, patenting and public engagement.

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The information about "CAR-OAC" are provided by the European Opendata Portal: CORDIS opendata.

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