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Carotid-artery-on-a-chip device to model thromboembolisms induced by vascular lesions and perform drug screenings

Total Cost €


EC-Contrib. €






 CAR-OAC project word cloud

Explore the words cloud of the CAR-OAC project. It provides you a very rough idea of what is the project "CAR-OAC" about.

patenting    carotid    ip    intravascular    device    applicable    extra    lumen    stretching    microfluidic    inflammatory    designed    dimensions    clinicians    biological    resolution    enriching    flow    trigger    diameter    experiments    marketing    rheological    mm    arteries    developers    equipped    thickness    lipids    tissue    researcher    confocal    transient    platelets    pharmaceutical    composition    intended    pathology    tia    live    pressure    engage    shear    microscopy    illustrated    engagement    master    occlusions    fibrinogen    ischaemic    avail    mechanics    whereas    death    designing    tias    therapeutic    agents    haemodynamics    thrombosis    globally    erythrocytes    elvesys    varied    liquids    artery    stroke    conducting    internal    actions    environment    stretch    cranial    blood    tested    visualize    7mm    physiologically    modulated    mechanically    coagulation    strokes    mimetic    public    physical    associations    inducing    solutions    visualization    biologically    attacks    proximal    vascular    explore    subjected    exposure   

Project "CAR-OAC" data sheet

The following table provides information about the project.


Organization address
city: PARIS
postcode: 75011

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 196˙707 €
 EC max contribution 196˙707 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-SE
 Starting year 2020
 Duration (year-month-day) from 2020-02-17   to  2022-02-16


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ELVESYS FR (PARIS) coordinator 196˙707.00


 Project objective

This project will be focused on designing a microfluidic device to visualize haemodynamics within a carotid-artery mimetic device. The system will be designed to evaluate associations especially between fibrinogen, erythrocytes, and platelets when subjected to shear and coagulation-inducing factors. The design will include biologically and mechanically variable properties as may occur in transient ischaemic attacks (TIA). The intended system is to have similar composition and dimensions as the extra-cranial (common to internal) carotid arteries. Physiologically relevant dimensions will be implemented where the common artery will have a lumen diameter of 6.1 mm with variable thickness (0.6 to 0.9 mm), whereas the internal artery will be 4.7 mm in diameter with thickness of 0.7mm. The system will be equipped with pressure and stretch-inducing mechanics which can be modulated to trigger rheological and biological responses. Specifically, stretching will cause exposure of tissue factor and lipids, capable of triggering inflammatory coagulation. The proximal formation of biological or physical occlusions will be assessed using this device. Also, the design will enable visualization of intra-vascular activity as may be illustrated in live high-resolution confocal microscopy. Flow properties of liquids with varied rheological properties similar to blood will be tested. Clinicians and researchers studying the pathology of strokes and TIAs or conducting studies on intravascular thrombosis will be able to engage this device in experiments while pharmaceutical developers will be able to engage the device in testing actions of therapeutic agents. Stroke remains the second leading cause of death globally and through the development of this device, both developers and potential users of the device will be able to explore effective and applicable solutions. Elvesys will avail the researcher an enriching environment to master IP, marketing concepts, patenting and public engagement.

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The information about "CAR-OAC" are provided by the European Opendata Portal: CORDIS opendata.

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