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CAR-OAC SIGNED

Carotid-artery-on-a-chip device to model thromboembolisms induced by vascular lesions and perform drug screenings

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 CAR-OAC project word cloud

Explore the words cloud of the CAR-OAC project. It provides you a very rough idea of what is the project "CAR-OAC" about.

shear    applicable    coagulation    therapeutic    mechanically    extra    live    microscopy    cranial    occlusions    avail    haemodynamics    biological    marketing    lipids    agents    biologically    dimensions    subjected    vascular    whereas    mm    associations    platelets    erythrocytes    designed    carotid    illustrated    device    pressure    physical    blood    7mm    actions    ip    visualize    arteries    pharmaceutical    tested    rheological    tissue    environment    transient    pathology    public    tia    elvesys    diameter    engagement    lumen    resolution    engage    enriching    clinicians    master    artery    conducting    patenting    proximal    strokes    exposure    intravascular    globally    experiments    stretching    inducing    liquids    flow    fibrinogen    intended    mechanics    equipped    trigger    inflammatory    varied    microfluidic    explore    visualization    ischaemic    physiologically    death    stretch    internal    stroke    developers    tias    mimetic    thrombosis    solutions    composition    attacks    confocal    thickness    designing    modulated    researcher   

Project "CAR-OAC" data sheet

The following table provides information about the project.

Coordinator		 ELVESYS 

Organization address
address: 1-3 BIS RUE ROBERT ET SONIA DELAUNAY
city: PARIS
postcode: 75011
website: www.elvesys.com

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country France [FR]
 Total cost 196˙707 €
 EC max contribution 196˙707 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-SE
 Starting year 2020
 Duration (year-month-day) from 2020-02-17   to  2022-02-16

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ELVESYS FR (PARIS) coordinator 196˙707.00

Map

 Project objective

This project will be focused on designing a microfluidic device to visualize haemodynamics within a carotid-artery mimetic device. The system will be designed to evaluate associations especially between fibrinogen, erythrocytes, and platelets when subjected to shear and coagulation-inducing factors. The design will include biologically and mechanically variable properties as may occur in transient ischaemic attacks (TIA). The intended system is to have similar composition and dimensions as the extra-cranial (common to internal) carotid arteries. Physiologically relevant dimensions will be implemented where the common artery will have a lumen diameter of 6.1 mm with variable thickness (0.6 to 0.9 mm), whereas the internal artery will be 4.7 mm in diameter with thickness of 0.7mm. The system will be equipped with pressure and stretch-inducing mechanics which can be modulated to trigger rheological and biological responses. Specifically, stretching will cause exposure of tissue factor and lipids, capable of triggering inflammatory coagulation. The proximal formation of biological or physical occlusions will be assessed using this device. Also, the design will enable visualization of intra-vascular activity as may be illustrated in live high-resolution confocal microscopy. Flow properties of liquids with varied rheological properties similar to blood will be tested. Clinicians and researchers studying the pathology of strokes and TIAs or conducting studies on intravascular thrombosis will be able to engage this device in experiments while pharmaceutical developers will be able to engage the device in testing actions of therapeutic agents. Stroke remains the second leading cause of death globally and through the development of this device, both developers and potential users of the device will be able to explore effective and applicable solutions. Elvesys will avail the researcher an enriching environment to master IP, marketing concepts, patenting and public engagement.

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The information about "CAR-OAC" are provided by the European Opendata Portal: CORDIS opendata.

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