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ELECTROSULF SIGNED

Electrochemical Sulfonylation of Lysine Residues in Continuous Flow Microreactors.

Total Cost €

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EC-Contrib. €

0

Partnership

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 ELECTROSULF project word cloud

Explore the words cloud of the ELECTROSULF project. It provides you a very rough idea of what is the project "ELECTROSULF" about.

miniaturization    electrochemical    modify    continuous    market    consequence    mechanism    background    molecules    preferred    sulfonamide    older    employed    last    organic    alternative    modification    moieties    chemistry    metal    microreactors    drugs    expertise    strategies    minimize    connected    modern    properly    transfer    cross    synthetic    selectively    ubiquitous    discovered    labels    oxidation    reported    me    reaction    drawbacks    electrolyte    relevance    group    oxidative    mass    microreactor    introduce    constant    sulfonyl    limitation    peptides    electrosulf    arylation    global    literature    euml    look    supporting    sulfonylations    proven    no    handles    flow    employment    photocatalysis    difficulties    paving    free    electrosynthesis    motivate    pharmaceutical    lysine    fluorescent    greener    re    acylation    alkylation    transformations    prof    amine    difficult    guarantee    biological    coupling    condensation    advantageous    cytotoxic    experiencing    chemists    achievement    timothy    appealing    catalysis    peptide    transition    sulfonylation    thanks   

Project "ELECTROSULF" data sheet

The following table provides information about the project.

Coordinator
TECHNISCHE UNIVERSITEIT EINDHOVEN 

Organization address
address: GROENE LOPER 3
city: EINDHOVEN
postcode: 5612 AE
website: www.tue.nl/en

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 175˙572 €
 EC max contribution 175˙572 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-09-05   to  2021-09-04

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    TECHNISCHE UNIVERSITEIT EINDHOVEN NL (EINDHOVEN) coordinator 175˙572.00

Map

 Project objective

Peptides are important molecules, ubiquitous in biological systems. Their relevance in the pharmaceutical sector is proven by the constant increase which the global market of peptide-based drugs is experiencing in the last years. As a consequence, several methods have been developed to modify peptides (e.g. condensation, cross-coupling, transition-metal catalysis, and photocatalysis), being lysine with its free amine one of the most preferred handles used by chemists to introduce a new moieties, e.g. cytotoxic drugs or fluorescent labels. Several transformations as alkylation, arylation, oxidation, acylation and condensation have been described for lysine. However, it would be very appealing to introduce selectively a sulfonyl group, which would result in the formation of a sulfonamide, a functionality which is widely employed in drugs. Although several oxidative sulfonylations are reported in the literature, their drawbacks motivate me to look for greener synthetic strategies. Electrosynthesis represents an advantageous alternative, which has been re-discovered in the last years also thanks to its employment in continuous-flow microreactors. With the support of this modern technology, it is possible to minimize the difficulties connected to older electrochemical processes (such as mass-transfer limitation, the need of a supporting electrolyte,and the difficult scale-up). ELECTROSULF aims at developing a novel sulfonylation of lysine by electrochemical means with the use of a flow microreactor. The reaction mechanism will be also properly studied. My strong background in organic chemistry together with Prof. Timothy Noël’s expertise in flow processes and reaction miniaturization will guarantee the success of ELECTROSULF, whose achievement will have a great impact on the pharmaceutical sector, paving the path to a new approach for peptide modification.

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The information about "ELECTROSULF" are provided by the European Opendata Portal: CORDIS opendata.

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