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OPIOIDREWARD SIGNED

How distress alters opioid drug effects and abuse liability

Total Cost €

0

EC-Contrib. €

0

Partnership

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 OPIOIDREWARD project word cloud

Explore the words cloud of the OPIOIDREWARD project. It provides you a very rough idea of what is the project "OPIOIDREWARD" about.

contain    addiction    clinical    humans    administration    sum    imaging    profound    designed    functional    animal    turn    opioid    blocking    head    mechanistic    potentially    brain    risk    network    converge    methodology    human    questions    create    despite    confirm    computational    opioids    model    hypothesis    contributions    epidemic    epidemiological    charting    healthy    unknown    self    dopamine    sidestepping    independent    powerful    abuse    feel    falsify    underlying    hotly    as    arising    report    poor    policies    physiological    elucidate    wanting    offers    mechanisms    tremendous    drug    hijack    liability    debated    underpinning    reward    implications    breakthrough    morphine    links    relief    people    first    influence    acute    blockade    drugs    science    induction    addictive    alter    enhances    psychological    escalates    stressors    liking    ask    resolving    distress    dependent    social    underpinnings    care    animals   

Project "OPIOIDREWARD" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITETET I OSLO 

Organization address
address: PROBLEMVEIEN 5-7
city: OSLO
postcode: 313
website: www.uio.no

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Norway [NO]
 Total cost 1˙500˙000 €
 EC max contribution 1˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-07-01   to  2024-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITETET I OSLO NO (OSLO) coordinator 1˙500˙000.00

Map

 Project objective

As the opioid epidemic escalates, we must ask: why are opioids so addictive? Non-human animal research links addiction with the powerful relief opioids can offer to animals in distress. In humans, epidemiological and clinical studies converge upon social stressors and a poor social support network as key risk factors for addiction. Despite this, it is currently unknown how pre-drug distress might alter opioid drug effects. Tremendous resources are dedicated to charting how people feel after taking a drug, sidestepping the potentially profound influence of how people feel before they take the drug. Here, I will turn the current approach on its head. Using acute social distress induction before morphine administration in healthy humans, I will create a human model to determine the psychological, physiological and brain underpinnings of how social stressors increase opioids’ abuse liability.

First, I will test the hypothesis that pre-drug distress enhances drug wanting (self-administration) but not drug liking (self-report) compared to drug effects in a control condition. Second, I will use opioid blockade to confirm or falsify the hypothesis that opioid drugs ‘hijack’ brain mechanisms underpinning social support. Third, I will determine to what extent opioid drug effects are dopamine-dependent by blocking dopamine before morphine administration. I will also apply computational modelling and functional imaging to elucidate the underlying brain mechanisms. Thus, the proposal offers a powerful new methodology for resolving hotly debated questions on the independent contributions of opioids and dopamine for reward and abuse liability.

In sum, the project aims to achieve a breakthrough in our understanding of how a pre-drug social distress state can alter opioid drug mechanisms. The mechanistic understanding arising from this project could have profound implications for science, as well as for clinical care and new policies designed to contain the opioid epidemic.

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The information about "OPIOIDREWARD" are provided by the European Opendata Portal: CORDIS opendata.

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