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OPIOIDREWARD SIGNED

How distress alters opioid drug effects and abuse liability

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 OPIOIDREWARD project word cloud

Explore the words cloud of the OPIOIDREWARD project. It provides you a very rough idea of what is the project "OPIOIDREWARD" about.

dopamine    risk    liking    report    opioids    poor    humans    opioid    policies    charting    psychological    drugs    arising    distress    liability    reward    epidemiological    blocking    stressors    create    science    ask    self    addiction    turn    questions    brain    acute    tremendous    alter    resolving    first    underpinning    influence    implications    human    epidemic    social    sum    contributions    potentially    people    underpinnings    designed    wanting    administration    computational    healthy    profound    head    addictive    escalates    breakthrough    sidestepping    powerful    clinical    blockade    mechanisms    debated    morphine    relief    drug    independent    hypothesis    hijack    elucidate    feel    imaging    as    animal    enhances    unknown    care    physiological    offers    induction    dependent    contain    falsify    functional    links    mechanistic    model    abuse    hotly    network    underlying    despite    methodology    converge    confirm    animals   

Project "OPIOIDREWARD" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITETET I OSLO 

Organization address
address: PROBLEMVEIEN 5-7
city: OSLO
postcode: 313
website: www.uio.no

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Norway [NO]
 Total cost 1˙500˙000 €
 EC max contribution 1˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-07-01   to  2024-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITETET I OSLO NO (OSLO) coordinator 1˙500˙000.00

Map

 Project objective

As the opioid epidemic escalates, we must ask: why are opioids so addictive? Non-human animal research links addiction with the powerful relief opioids can offer to animals in distress. In humans, epidemiological and clinical studies converge upon social stressors and a poor social support network as key risk factors for addiction. Despite this, it is currently unknown how pre-drug distress might alter opioid drug effects. Tremendous resources are dedicated to charting how people feel after taking a drug, sidestepping the potentially profound influence of how people feel before they take the drug. Here, I will turn the current approach on its head. Using acute social distress induction before morphine administration in healthy humans, I will create a human model to determine the psychological, physiological and brain underpinnings of how social stressors increase opioids’ abuse liability.

First, I will test the hypothesis that pre-drug distress enhances drug wanting (self-administration) but not drug liking (self-report) compared to drug effects in a control condition. Second, I will use opioid blockade to confirm or falsify the hypothesis that opioid drugs ‘hijack’ brain mechanisms underpinning social support. Third, I will determine to what extent opioid drug effects are dopamine-dependent by blocking dopamine before morphine administration. I will also apply computational modelling and functional imaging to elucidate the underlying brain mechanisms. Thus, the proposal offers a powerful new methodology for resolving hotly debated questions on the independent contributions of opioids and dopamine for reward and abuse liability.

In sum, the project aims to achieve a breakthrough in our understanding of how a pre-drug social distress state can alter opioid drug mechanisms. The mechanistic understanding arising from this project could have profound implications for science, as well as for clinical care and new policies designed to contain the opioid epidemic.

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The information about "OPIOIDREWARD" are provided by the European Opendata Portal: CORDIS opendata.

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