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OPIOIDREWARD SIGNED

How distress alters opioid drug effects and abuse liability

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 OPIOIDREWARD project word cloud

Explore the words cloud of the OPIOIDREWARD project. It provides you a very rough idea of what is the project "OPIOIDREWARD" about.

underlying    stressors    hypothesis    feel    people    psychological    wanting    underpinning    designed    induction    links    abuse    questions    addictive    policies    animals    converge    debated    elucidate    despite    charting    liability    liking    blockade    powerful    epidemiological    dopamine    computational    methodology    confirm    epidemic    unknown    create    sidestepping    distress    model    animal    reward    turn    administration    mechanistic    falsify    healthy    sum    mechanisms    poor    clinical    influence    independent    acute    hotly    tremendous    arising    network    addiction    head    imaging    as    profound    morphine    physiological    escalates    human    alter    ask    potentially    risk    blocking    drug    breakthrough    self    functional    social    drugs    care    enhances    underpinnings    offers    hijack    opioid    dependent    implications    first    humans    report    opioids    science    contain    brain    contributions    relief    resolving   

Project "OPIOIDREWARD" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITETET I OSLO 

Organization address
address: PROBLEMVEIEN 5-7
city: OSLO
postcode: 313
website: www.uio.no

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Norway [NO]
 Total cost 1˙500˙000 €
 EC max contribution 1˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-07-01   to  2024-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITETET I OSLO NO (OSLO) coordinator 1˙500˙000.00

Map

 Project objective

As the opioid epidemic escalates, we must ask: why are opioids so addictive? Non-human animal research links addiction with the powerful relief opioids can offer to animals in distress. In humans, epidemiological and clinical studies converge upon social stressors and a poor social support network as key risk factors for addiction. Despite this, it is currently unknown how pre-drug distress might alter opioid drug effects. Tremendous resources are dedicated to charting how people feel after taking a drug, sidestepping the potentially profound influence of how people feel before they take the drug. Here, I will turn the current approach on its head. Using acute social distress induction before morphine administration in healthy humans, I will create a human model to determine the psychological, physiological and brain underpinnings of how social stressors increase opioids’ abuse liability.

First, I will test the hypothesis that pre-drug distress enhances drug wanting (self-administration) but not drug liking (self-report) compared to drug effects in a control condition. Second, I will use opioid blockade to confirm or falsify the hypothesis that opioid drugs ‘hijack’ brain mechanisms underpinning social support. Third, I will determine to what extent opioid drug effects are dopamine-dependent by blocking dopamine before morphine administration. I will also apply computational modelling and functional imaging to elucidate the underlying brain mechanisms. Thus, the proposal offers a powerful new methodology for resolving hotly debated questions on the independent contributions of opioids and dopamine for reward and abuse liability.

In sum, the project aims to achieve a breakthrough in our understanding of how a pre-drug social distress state can alter opioid drug mechanisms. The mechanistic understanding arising from this project could have profound implications for science, as well as for clinical care and new policies designed to contain the opioid epidemic.

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The information about "OPIOIDREWARD" are provided by the European Opendata Portal: CORDIS opendata.

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lastchecktime (2021-05-17 10:44:20) correctly updated