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IMMUNE SIGNED

Investigation into the Molecular Mechanisms Underlying NEmatode recognition by the Ma resistance protein in perennial plum roots

Total Cost €

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EC-Contrib. €

0

Partnership

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 IMMUNE project word cloud

Explore the words cloud of the IMMUNE project. It provides you a very rough idea of what is the project "IMMUNE" about.

resistant    nb    prunus    biological    root    opportunity    involvement    global    rkn    pl    function    interestingly    repeated    interleukin    post    signalling    peculiar    receptor    family    tree    extention    dr    molecular    resistance    saucet    worldwide    toxic    tnls    domain    absence    leucine    agrobiotech    nematodes    sophia    tnl    immunity    triggers    single    inra    causing    knot    tir    carries    participates    terminal    rely    describe    pathogens    meloidogyne    receptors    crop    predominant    banned    drastically    perennial    threat    parasitic    binding    cloned    immune    nucleotide    layered    pesticides    exons    disease    lrr    species    repeat    annual    conservation    mediated    huge    mechanisms    spp    broad    simon    crops    encoding    unknown    isa    suggests    architecture    complementary    undertaken    cerasifera    infection    innate    roots    found    detection    decipher    provides    insights    ma    network    losses    susceptible    gene    plum    mainly    recognition    resides    plant    rkns    toll    combining    classes    copy    alternative   

Project "IMMUNE" data sheet

The following table provides information about the project.

Coordinator
INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT 

Organization address
address: Rue De L'Universite 147
city: PARIS CEDEX 07
postcode: 75338
website: www.inra.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 184˙707 €
 EC max contribution 184˙707 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2019
 Duration (year-month-day) from 2019-11-15   to  2021-11-14

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT FR (PARIS CEDEX 07) coordinator 184˙707.00

Map

 Project objective

Plant-parasitic nematodes are major root pathogens that affect drastically plant development and growth. Predominant species, such as the root-knot nematodes (RKNs) Meloidogyne spp., represent a global threat for annual and perennial crops causing huge crop losses worldwide. In Europe, RKNs were mainly controlled by toxic pesticides that are getting banned. One of the most promising alternative to pesticides is to rely on biological control and on the plant innate immunity for disease resistance in crops. The plant immune system is a multi-layered network that enables the detection of pathogens using different classes of receptors. The presence/absence of such receptor can determine whether or not the plant will be resistant/susceptible to a particular disease. At INRA Sophia Agrobiotech Institute (ISA), an immune receptor gene Ma, from the toll/interleukin-1 receptor, nucleotide-binding and leucine-rich repeat (TIR-NB-LRR or TNL) family, has been cloned from the plum tree Prunus cerasifera where it provides a broad resistance against numerous RKN species. A unique feature of Ma resides in five repeated exons encoding a large C-terminal extention. Interestingly, each of those exons carries a recently characterized post-LRR (PL) domain which is found in a single copy in many other TNLs from different plant species. The PL domain’s function remains unknown but its conservation suggests an important role in TNLs. The peculiar architecture of Ma provides a great opportunity to decipher the involvement of the PL domain in TNL–mediated immunity. Combining complementary approaches, the proposed IMMUNE project aims to describe how Ma triggers immunity in response to RKNs in plant roots and how the PL domain participates in the recognition and signalling. This project, undertaken by Dr Simon Saucet at ISA, will provide new insights into the molecular mechanisms of plant immunity and contribute to the development of methods to control RKNs infection in crops.

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