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IMMUNE SIGNED

Investigation into the Molecular Mechanisms Underlying NEmatode recognition by the Ma resistance protein in perennial plum roots

Total Cost €

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EC-Contrib. €

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Partnership

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 IMMUNE project word cloud

Explore the words cloud of the IMMUNE project. It provides you a very rough idea of what is the project "IMMUNE" about.

conservation    detection    saucet    domain    immune    suggests    molecular    insights    receptors    cloned    triggers    huge    leucine    crop    parasitic    roots    peculiar    carries    biological    family    encoding    opportunity    nb    infection    interleukin    immunity    combining    meloidogyne    undertaken    nucleotide    predominant    repeated    found    mainly    unknown    innate    recognition    worldwide    pl    perennial    repeat    network    exons    receptor    architecture    ma    knot    isa    complementary    agrobiotech    inra    participates    binding    plum    tir    layered    post    copy    alternative    cerasifera    pesticides    gene    tree    classes    simon    susceptible    broad    mechanisms    dr    losses    resides    crops    terminal    resistant    prunus    interestingly    drastically    single    function    toxic    banned    sophia    plant    extention    annual    signalling    rkn    causing    involvement    toll    tnl    spp    species    decipher    rely    mediated    absence    root    lrr    global    threat    nematodes    disease    pathogens    rkns    provides    resistance    describe    tnls   

Project "IMMUNE" data sheet

The following table provides information about the project.

Coordinator
INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT 

Organization address
address: Rue De L'Universite 147
city: PARIS CEDEX 07
postcode: 75338
website: www.inra.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 184˙707 €
 EC max contribution 184˙707 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2019
 Duration (year-month-day) from 2019-11-15   to  2021-11-14

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT FR (PARIS CEDEX 07) coordinator 184˙707.00

Map

 Project objective

Plant-parasitic nematodes are major root pathogens that affect drastically plant development and growth. Predominant species, such as the root-knot nematodes (RKNs) Meloidogyne spp., represent a global threat for annual and perennial crops causing huge crop losses worldwide. In Europe, RKNs were mainly controlled by toxic pesticides that are getting banned. One of the most promising alternative to pesticides is to rely on biological control and on the plant innate immunity for disease resistance in crops. The plant immune system is a multi-layered network that enables the detection of pathogens using different classes of receptors. The presence/absence of such receptor can determine whether or not the plant will be resistant/susceptible to a particular disease. At INRA Sophia Agrobiotech Institute (ISA), an immune receptor gene Ma, from the toll/interleukin-1 receptor, nucleotide-binding and leucine-rich repeat (TIR-NB-LRR or TNL) family, has been cloned from the plum tree Prunus cerasifera where it provides a broad resistance against numerous RKN species. A unique feature of Ma resides in five repeated exons encoding a large C-terminal extention. Interestingly, each of those exons carries a recently characterized post-LRR (PL) domain which is found in a single copy in many other TNLs from different plant species. The PL domain’s function remains unknown but its conservation suggests an important role in TNLs. The peculiar architecture of Ma provides a great opportunity to decipher the involvement of the PL domain in TNL–mediated immunity. Combining complementary approaches, the proposed IMMUNE project aims to describe how Ma triggers immunity in response to RKNs in plant roots and how the PL domain participates in the recognition and signalling. This project, undertaken by Dr Simon Saucet at ISA, will provide new insights into the molecular mechanisms of plant immunity and contribute to the development of methods to control RKNs infection in crops.

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