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IMMUNE SIGNED

Investigation into the Molecular Mechanisms Underlying NEmatode recognition by the Ma resistance protein in perennial plum roots

Total Cost €

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EC-Contrib. €

0

Partnership

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 IMMUNE project word cloud

Explore the words cloud of the IMMUNE project. It provides you a very rough idea of what is the project "IMMUNE" about.

cerasifera    toll    exons    decipher    describe    mainly    receptors    detection    immunity    agrobiotech    pathogens    disease    conservation    crop    species    repeated    mediated    root    rkn    worldwide    innate    inra    network    global    dr    crops    rkns    layered    terminal    classes    single    function    predominant    resistant    infection    toxic    susceptible    pesticides    binding    resides    threat    huge    spp    unknown    interleukin    carries    biological    domain    absence    interestingly    nematodes    sophia    banned    mechanisms    provides    nucleotide    pl    drastically    alternative    copy    participates    suggests    simon    recognition    post    encoding    architecture    repeat    knot    annual    broad    involvement    cloned    molecular    extention    family    losses    found    roots    isa    triggers    resistance    leucine    insights    combining    tree    opportunity    immune    saucet    meloidogyne    gene    perennial    complementary    parasitic    prunus    causing    signalling    lrr    undertaken    receptor    nb    ma    peculiar    rely    tnls    tnl    tir    plum    plant   

Project "IMMUNE" data sheet

The following table provides information about the project.

Coordinator
INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT 

Organization address
address: Rue De L'Universite 147
city: PARIS CEDEX 07
postcode: 75338
website: www.inra.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 184˙707 €
 EC max contribution 184˙707 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2019
 Duration (year-month-day) from 2019-11-15   to  2021-11-14

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT FR (PARIS CEDEX 07) coordinator 184˙707.00

Map

 Project objective

Plant-parasitic nematodes are major root pathogens that affect drastically plant development and growth. Predominant species, such as the root-knot nematodes (RKNs) Meloidogyne spp., represent a global threat for annual and perennial crops causing huge crop losses worldwide. In Europe, RKNs were mainly controlled by toxic pesticides that are getting banned. One of the most promising alternative to pesticides is to rely on biological control and on the plant innate immunity for disease resistance in crops. The plant immune system is a multi-layered network that enables the detection of pathogens using different classes of receptors. The presence/absence of such receptor can determine whether or not the plant will be resistant/susceptible to a particular disease. At INRA Sophia Agrobiotech Institute (ISA), an immune receptor gene Ma, from the toll/interleukin-1 receptor, nucleotide-binding and leucine-rich repeat (TIR-NB-LRR or TNL) family, has been cloned from the plum tree Prunus cerasifera where it provides a broad resistance against numerous RKN species. A unique feature of Ma resides in five repeated exons encoding a large C-terminal extention. Interestingly, each of those exons carries a recently characterized post-LRR (PL) domain which is found in a single copy in many other TNLs from different plant species. The PL domain’s function remains unknown but its conservation suggests an important role in TNLs. The peculiar architecture of Ma provides a great opportunity to decipher the involvement of the PL domain in TNL–mediated immunity. Combining complementary approaches, the proposed IMMUNE project aims to describe how Ma triggers immunity in response to RKNs in plant roots and how the PL domain participates in the recognition and signalling. This project, undertaken by Dr Simon Saucet at ISA, will provide new insights into the molecular mechanisms of plant immunity and contribute to the development of methods to control RKNs infection in crops.

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