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IMMUNE SIGNED

Investigation into the Molecular Mechanisms Underlying NEmatode recognition by the Ma resistance protein in perennial plum roots

Total Cost €

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EC-Contrib. €

0

Partnership

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 IMMUNE project word cloud

Explore the words cloud of the IMMUNE project. It provides you a very rough idea of what is the project "IMMUNE" about.

tree    tir    sophia    undertaken    resistance    species    participates    interestingly    threat    parasitic    exons    predominant    post    crops    molecular    cloned    rkns    infection    inra    family    leucine    recognition    involvement    function    insights    root    absence    suggests    toxic    rkn    prunus    lrr    immunity    provides    binding    carries    classes    biological    pesticides    drastically    receptor    pathogens    cerasifera    immune    conservation    nb    peculiar    causing    copy    spp    isa    mainly    gene    roots    unknown    encoding    saucet    crop    decipher    plum    ma    disease    perennial    interleukin    knot    losses    extention    complementary    resides    repeat    worldwide    huge    triggers    simon    receptors    domain    repeated    detection    broad    signalling    agrobiotech    annual    pl    nematodes    single    global    resistant    alternative    meloidogyne    nucleotide    rely    banned    plant    combining    tnls    susceptible    mechanisms    describe    innate    layered    found    dr    toll    network    opportunity    architecture    terminal    tnl    mediated   

Project "IMMUNE" data sheet

The following table provides information about the project.

Coordinator
INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT 

Organization address
address: Rue De L'Universite 147
city: PARIS CEDEX 07
postcode: 75338
website: www.inra.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 184˙707 €
 EC max contribution 184˙707 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2019
 Duration (year-month-day) from 2019-11-15   to  2021-11-14

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT FR (PARIS CEDEX 07) coordinator 184˙707.00

Map

 Project objective

Plant-parasitic nematodes are major root pathogens that affect drastically plant development and growth. Predominant species, such as the root-knot nematodes (RKNs) Meloidogyne spp., represent a global threat for annual and perennial crops causing huge crop losses worldwide. In Europe, RKNs were mainly controlled by toxic pesticides that are getting banned. One of the most promising alternative to pesticides is to rely on biological control and on the plant innate immunity for disease resistance in crops. The plant immune system is a multi-layered network that enables the detection of pathogens using different classes of receptors. The presence/absence of such receptor can determine whether or not the plant will be resistant/susceptible to a particular disease. At INRA Sophia Agrobiotech Institute (ISA), an immune receptor gene Ma, from the toll/interleukin-1 receptor, nucleotide-binding and leucine-rich repeat (TIR-NB-LRR or TNL) family, has been cloned from the plum tree Prunus cerasifera where it provides a broad resistance against numerous RKN species. A unique feature of Ma resides in five repeated exons encoding a large C-terminal extention. Interestingly, each of those exons carries a recently characterized post-LRR (PL) domain which is found in a single copy in many other TNLs from different plant species. The PL domain’s function remains unknown but its conservation suggests an important role in TNLs. The peculiar architecture of Ma provides a great opportunity to decipher the involvement of the PL domain in TNL–mediated immunity. Combining complementary approaches, the proposed IMMUNE project aims to describe how Ma triggers immunity in response to RKNs in plant roots and how the PL domain participates in the recognition and signalling. This project, undertaken by Dr Simon Saucet at ISA, will provide new insights into the molecular mechanisms of plant immunity and contribute to the development of methods to control RKNs infection in crops.

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