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THERA SIGNED

Therapeutic Drug Monitoring with Smartphone-integrated Surface Enhanced Raman Spectroscopy

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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0

 THERA project word cloud

Explore the words cloud of the THERA project. It provides you a very rough idea of what is the project "THERA" about.

chromatography    specialized    ms    commercially    consistent    minimum    smartphone    sers    samples    routine    sized    spectroscopy    exclusively    utility    lc    drug    measuring    drugs    perform    variety    analytes    efficacy    immunoassays    laboratories    mass    first    circulating    artificial    therapeutic    data    toxicity    validate    alternative    adverse    narrow    weight    enhanced    limit    output    maintenance    intervals    maximise    raman    hospitals    reactions    tool    liquid    blood    commercial    fraction    minutes    patients    concentration    readiness    performance    elisa    prevent    monitoring    spectrometry    adaptability    size    experimentally    droplet    tabletop    throughput    transform    thera    proposition    surface    pure    device    miniaturized    clinical    business    detection    shown    central    barriers    feasibility    plasma    de    hplc    complexity    technologies    molecules    mu    verified    single    tdm    analyte    friendliness    designated   

Project "THERA" data sheet

The following table provides information about the project.

Coordinator
DANMARKS TEKNISKE UNIVERSITET 

Organization address
address: ANKER ENGELUNDSVEJ 1 BYGNING 101 A
city: KGS LYNGBY
postcode: 2800
website: www.dtu.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Total cost 0 €
 EC max contribution 150˙000 € (0%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-PoC
 Funding Scheme ERC-POC-LS
 Starting year 2020
 Duration (year-month-day) from 2020-02-01   to  2021-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    DANMARKS TEKNISKE UNIVERSITET DK (KGS LYNGBY) coordinator 150˙000.00

Map

 Project objective

Therapeutic drug monitoring (TDM) is an essential tool for measuring the circulating concentration of specific narrow therapeutic drugs at designated intervals, in order to maximise the efficacy of the drug and avoid toxicity and adverse drug reactions. TDM is currently available only in central laboratories or large hospitals, and several barriers prevent its wide implementation in routine clinical practice. First, current technologies used for TDM (e.g. high-performance liquid chromatography – HPLC, mass spectrometry – MS) are exclusively used in central laboratories due to their cost, system size and weight, complexity of use and maintenance requirements. Second, alternative technologies (e.g. ELISA immunoassays) are analyte-specific and do not allow adaptability to new analytes (increasing costs). We verified the feasibility and clinical utility of using Surface Enhanced Raman Spectroscopy (SERS) for TDM using real plasma samples taken from de-identified patients. Importantly, our measurements were consistent with state-of-the-art data generated by LC-MS/MS. We already have experimentally shown a 0.1 μM detection limit on pure, artificial samples. Within THERA, we aim to transform our research output into a commercially-relevant (in terms of size, throughput, user friendliness and cost) product by creating a minimum viable product that will enable TDM for a wide variety of molecules. Our goal within this project is to validate this device on clinical samples and build a strong business case for it that will enable commercial exploitation. THERA will advance our SERS-based device from a current technology readiness level of 3 to 5/6. Our value proposition is a tabletop, miniaturized (smartphone-sized) device that can perform TDM on a single droplet of blood, in a matter of minutes, without the need for specialized personnel, at a fraction of the cost currently associated with TDM.

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The information about "THERA" are provided by the European Opendata Portal: CORDIS opendata.

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