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THERA SIGNED

Therapeutic Drug Monitoring with Smartphone-integrated Surface Enhanced Raman Spectroscopy

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 THERA project word cloud

Explore the words cloud of the THERA project. It provides you a very rough idea of what is the project "THERA" about.

prevent    central    business    adverse    drug    mass    single    commercial    lc    drugs    data    patients    circulating    enhanced    first    adaptability    weight    device    laboratories    shown    samples    thera    ms    therapeutic    commercially    limit    mu    sized    maintenance    chromatography    raman    surface    validate    output    hplc    hospitals    detection    smartphone    designated    clinical    specialized    sers    throughput    feasibility    perform    utility    efficacy    elisa    minimum    de    monitoring    fraction    readiness    analytes    droplet    artificial    performance    size    concentration    miniaturized    minutes    tdm    measuring    consistent    pure    complexity    variety    exclusively    friendliness    barriers    tool    technologies    narrow    reactions    intervals    immunoassays    spectrometry    transform    maximise    proposition    alternative    routine    experimentally    liquid    molecules    analyte    verified    tabletop    toxicity    blood    spectroscopy    plasma   

Project "THERA" data sheet

The following table provides information about the project.

Coordinator
DANMARKS TEKNISKE UNIVERSITET 

Organization address
address: ANKER ENGELUNDSVEJ 1 BYGNING 101 A
city: KGS LYNGBY
postcode: 2800
website: www.dtu.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Total cost 0 €
 EC max contribution 150˙000 € (0%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-PoC
 Funding Scheme ERC-POC-LS
 Starting year 2020
 Duration (year-month-day) from 2020-02-01   to  2021-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    DANMARKS TEKNISKE UNIVERSITET DK (KGS LYNGBY) coordinator 150˙000.00

Map

 Project objective

Therapeutic drug monitoring (TDM) is an essential tool for measuring the circulating concentration of specific narrow therapeutic drugs at designated intervals, in order to maximise the efficacy of the drug and avoid toxicity and adverse drug reactions. TDM is currently available only in central laboratories or large hospitals, and several barriers prevent its wide implementation in routine clinical practice. First, current technologies used for TDM (e.g. high-performance liquid chromatography – HPLC, mass spectrometry – MS) are exclusively used in central laboratories due to their cost, system size and weight, complexity of use and maintenance requirements. Second, alternative technologies (e.g. ELISA immunoassays) are analyte-specific and do not allow adaptability to new analytes (increasing costs). We verified the feasibility and clinical utility of using Surface Enhanced Raman Spectroscopy (SERS) for TDM using real plasma samples taken from de-identified patients. Importantly, our measurements were consistent with state-of-the-art data generated by LC-MS/MS. We already have experimentally shown a 0.1 μM detection limit on pure, artificial samples. Within THERA, we aim to transform our research output into a commercially-relevant (in terms of size, throughput, user friendliness and cost) product by creating a minimum viable product that will enable TDM for a wide variety of molecules. Our goal within this project is to validate this device on clinical samples and build a strong business case for it that will enable commercial exploitation. THERA will advance our SERS-based device from a current technology readiness level of 3 to 5/6. Our value proposition is a tabletop, miniaturized (smartphone-sized) device that can perform TDM on a single droplet of blood, in a matter of minutes, without the need for specialized personnel, at a fraction of the cost currently associated with TDM.

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The information about "THERA" are provided by the European Opendata Portal: CORDIS opendata.

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lastchecktime (2022-11-28 12:12:27) correctly updated