Explore the words cloud of the BISBORONDYKAT project. It provides you a very rough idea of what is the project "BISBORONDYKAT" about.
The following table provides information about the project.
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
|Coordinator Country||United Kingdom [UK]|
|Total cost||212˙933 €|
|EC max contribution||212˙933 € (100%)|
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
|Duration (year-month-day)||from 2020-07-01 to 2022-06-30|
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|1||THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD||UK (OXFORD)||coordinator||212˙933.00|
Suzuki−Miyaura coupling (SMC) has emerged as a powerful strategy in the field of cross-coupling reactions and is widely used in synthetic organic chemistry and drug development. Asymmetric SMC reactions employing aryl/alkenyl boronic acid is well developed; however, no general Csp3 – Csp3 Suzuki-Miyaura coupling is currently available. Furthermore, the asymmetric addition of benzylic nucleophile or 1,1-difunctionalized reagents as a nucleophile is quite rare.
This proposal aims to develop a general cross-coupling procedure that will effectively allow the use of 1,1-bisboryl alkanes in asymmetric SMC reactions. We intend to utilise the rhodium and copper catalysed dynamic kinetic asymmetric transformations (DYKAT) protocol developed in the Fletcher group to achieve this transformation. The corresponding enantioenriched product would feature boronic ester moiety equipped for further modification. Furthermore, the transformation would serve as an alternative protocol for the addition of difficult to install benzylic group. The method would provide a significant advancement in asymmetric cross-coupling reactions and would fortify the broad applicability of DYKATs in SMC reactions in the field of synthesis, medicinal and materials chemistry.
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