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BEBOP SIGNED

Bacterial biofilms in porous structures: from biomechanics to control

Total Cost €

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EC-Contrib. €

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Partnership

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 BEBOP project word cloud

Explore the words cloud of the BEBOP project. It provides you a very rough idea of what is the project "BEBOP" about.

printed    phenomena    first    extract    network    fantastic    gain    basis    combine    residence    biology    ray    initial    fundamental    experiments    blending    porous    biomechanics    theory    hypothesis    multiscale    quantities    principles    mechanisms    biophysical    times    cfd    complexity    ratios    dynamic    microbiology    translation    generation    toward    lack    3d    synthetic    flow    biofilms    single    industrial    reversible    theoretical    individual    scientific    proof    bioreactors    primary    micro    scaffold    unlock    ecology    stable    media    performance    precise    interact    blocks    connected    fluorescence    imaging    central    pore    models    bacterial    rates    solute    implications    yield    ideas    reaction    bioreactor    conversely    microbial    physical    microorganisms    building    universal    biofilm    biotechnologies    motivating    transport    obstacle    envision    create    bacteria    heterogeneous    surface    structures    ranging    volume    permeability    microfluidic    biological    fluid    engineering    computing    designs    innovative    strain   

Project "BEBOP" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 1˙649˙861 €
 EC max contribution 1˙649˙861 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-01-01   to  2023-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 1˙649˙861.00

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 Project objective

The key ideas motivating this project are that: 1) precise control of the properties of porous systems can be obtained by exploiting bacteria and their fantastic abilities; 2) conversely, porous media (large surface to volume ratios, complex structures) could be a major part of bacterial synthetic biology, as a scaffold for growing large quantities of microorganisms in controlled bioreactors.

The main scientific obstacle to precise control of such processes is the lack of understanding of biophysical mechanisms in complex porous structures, even in the case of single-strain biofilms. The central hypothesis of this project is that a better fundamental understanding of biofilm biomechanics and physical ecology will yield a novel theoretical basis for engineering and control.

The first scientific objective is thus to gain insight into how fluid flow, transport phenomena and biofilms interact within connected multiscale heterogeneous structures - a major scientific challenge with wide-ranging implications. To this end, we will combine microfluidic and 3D printed micro-bioreactor experiments; fluorescence and X-ray imaging; high performance computing blending CFD, individual-based models and pore network approaches.

The second scientific objective is to create the primary building blocks toward a control theory of bacteria in porous media and innovative designs of microbial bioreactors. Building upon the previous objective, we first aim to extract from the complexity of biological responses the most universal engineering principles applying to such systems. We will then design a novel porous micro-bioreactor to demonstrate how the permeability and solute residence times can be controlled in a dynamic, reversible and stable way - an initial step toward controlling reaction rates.

We envision that this will unlock a new generation of biotechnologies and novel bioreactor designs enabling translation from proof-of-concept synthetic microbiology to industrial processes.

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The information about "BEBOP" are provided by the European Opendata Portal: CORDIS opendata.

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