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BEBOP SIGNED

Bacterial biofilms in porous structures: from biomechanics to control

Total Cost €

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EC-Contrib. €

0

Partnership

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 BEBOP project word cloud

Explore the words cloud of the BEBOP project. It provides you a very rough idea of what is the project "BEBOP" about.

synthetic    theory    individual    create    building    bacteria    flow    single    porous    rates    obstacle    unlock    volume    biophysical    permeability    printed    principles    experiments    blending    hypothesis    quantities    combine    biotechnologies    designs    translation    precise    microorganisms    cfd    ranging    structures    bioreactors    bacterial    scaffold    micro    media    proof    pore    conversely    computing    heterogeneous    times    mechanisms    biofilm    complexity    phenomena    engineering    implications    lack    reversible    dynamic    residence    fluorescence    theoretical    imaging    bioreactor    gain    network    fluid    3d    central    biological    blocks    biology    performance    primary    industrial    microbial    motivating    biofilms    ideas    scientific    generation    models    envision    fundamental    connected    microbiology    solute    strain    surface    physical    transport    microfluidic    yield    ray    reaction    biomechanics    basis    first    fantastic    toward    initial    ratios    ecology    innovative    interact    extract    universal    stable    multiscale   

Project "BEBOP" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 1˙649˙861 €
 EC max contribution 1˙649˙861 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-01-01   to  2023-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 1˙649˙861.00

Map

 Project objective

The key ideas motivating this project are that: 1) precise control of the properties of porous systems can be obtained by exploiting bacteria and their fantastic abilities; 2) conversely, porous media (large surface to volume ratios, complex structures) could be a major part of bacterial synthetic biology, as a scaffold for growing large quantities of microorganisms in controlled bioreactors.

The main scientific obstacle to precise control of such processes is the lack of understanding of biophysical mechanisms in complex porous structures, even in the case of single-strain biofilms. The central hypothesis of this project is that a better fundamental understanding of biofilm biomechanics and physical ecology will yield a novel theoretical basis for engineering and control.

The first scientific objective is thus to gain insight into how fluid flow, transport phenomena and biofilms interact within connected multiscale heterogeneous structures - a major scientific challenge with wide-ranging implications. To this end, we will combine microfluidic and 3D printed micro-bioreactor experiments; fluorescence and X-ray imaging; high performance computing blending CFD, individual-based models and pore network approaches.

The second scientific objective is to create the primary building blocks toward a control theory of bacteria in porous media and innovative designs of microbial bioreactors. Building upon the previous objective, we first aim to extract from the complexity of biological responses the most universal engineering principles applying to such systems. We will then design a novel porous micro-bioreactor to demonstrate how the permeability and solute residence times can be controlled in a dynamic, reversible and stable way - an initial step toward controlling reaction rates.

We envision that this will unlock a new generation of biotechnologies and novel bioreactor designs enabling translation from proof-of-concept synthetic microbiology to industrial processes.

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The information about "BEBOP" are provided by the European Opendata Portal: CORDIS opendata.

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