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BEBOP SIGNED

Bacterial biofilms in porous structures: from biomechanics to control

Total Cost €

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EC-Contrib. €

0

Partnership

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 BEBOP project word cloud

Explore the words cloud of the BEBOP project. It provides you a very rough idea of what is the project "BEBOP" about.

scientific    residence    proof    biofilms    bioreactors    microbial    envision    heterogeneous    obstacle    rates    innovative    blocks    computing    fluorescence    microorganisms    quantities    bacterial    biophysical    physical    implications    flow    first    pore    ranging    transport    microfluidic    porous    central    connected    biotechnologies    mechanisms    media    scaffold    bacteria    universal    imaging    volume    biomechanics    precise    models    generation    fantastic    phenomena    permeability    biofilm    experiments    fundamental    designs    cfd    ray    create    biological    strain    fluid    lack    individual    micro    unlock    motivating    interact    printed    times    building    reaction    solute    single    basis    engineering    synthetic    principles    translation    ideas    network    blending    gain    primary    biology    yield    ecology    theory    3d    performance    reversible    initial    surface    extract    hypothesis    industrial    structures    theoretical    complexity    conversely    stable    dynamic    bioreactor    multiscale    toward    ratios    microbiology    combine   

Project "BEBOP" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 1˙649˙861 €
 EC max contribution 1˙649˙861 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-01-01   to  2023-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 1˙649˙861.00

Map

 Project objective

The key ideas motivating this project are that: 1) precise control of the properties of porous systems can be obtained by exploiting bacteria and their fantastic abilities; 2) conversely, porous media (large surface to volume ratios, complex structures) could be a major part of bacterial synthetic biology, as a scaffold for growing large quantities of microorganisms in controlled bioreactors.

The main scientific obstacle to precise control of such processes is the lack of understanding of biophysical mechanisms in complex porous structures, even in the case of single-strain biofilms. The central hypothesis of this project is that a better fundamental understanding of biofilm biomechanics and physical ecology will yield a novel theoretical basis for engineering and control.

The first scientific objective is thus to gain insight into how fluid flow, transport phenomena and biofilms interact within connected multiscale heterogeneous structures - a major scientific challenge with wide-ranging implications. To this end, we will combine microfluidic and 3D printed micro-bioreactor experiments; fluorescence and X-ray imaging; high performance computing blending CFD, individual-based models and pore network approaches.

The second scientific objective is to create the primary building blocks toward a control theory of bacteria in porous media and innovative designs of microbial bioreactors. Building upon the previous objective, we first aim to extract from the complexity of biological responses the most universal engineering principles applying to such systems. We will then design a novel porous micro-bioreactor to demonstrate how the permeability and solute residence times can be controlled in a dynamic, reversible and stable way - an initial step toward controlling reaction rates.

We envision that this will unlock a new generation of biotechnologies and novel bioreactor designs enabling translation from proof-of-concept synthetic microbiology to industrial processes.

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The information about "BEBOP" are provided by the European Opendata Portal: CORDIS opendata.

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