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BEBOP SIGNED

Bacterial biofilms in porous structures: from biomechanics to control

Total Cost €

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EC-Contrib. €

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Partnership

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 BEBOP project word cloud

Explore the words cloud of the BEBOP project. It provides you a very rough idea of what is the project "BEBOP" about.

synthetic    motivating    permeability    reversible    porous    imaging    phenomena    network    multiscale    blending    reaction    times    obstacle    micro    gain    microbial    toward    microorganisms    precise    extract    pore    stable    biofilms    theory    mechanisms    performance    fluorescence    proof    biological    biophysical    rates    fantastic    theoretical    bioreactor    primary    ratios    ray    industrial    hypothesis    combine    engineering    individual    flow    connected    biotechnologies    bacteria    designs    dynamic    quantities    solute    ranging    basis    3d    central    ecology    universal    interact    translation    ideas    complexity    bacterial    biology    biofilm    volume    microbiology    media    biomechanics    implications    blocks    building    residence    lack    models    envision    cfd    yield    initial    generation    heterogeneous    structures    transport    principles    bioreactors    physical    printed    fundamental    create    experiments    conversely    computing    single    unlock    strain    microfluidic    scientific    fluid    first    surface    innovative    scaffold   

Project "BEBOP" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 1˙649˙861 €
 EC max contribution 1˙649˙861 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-01-01   to  2023-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 1˙649˙861.00

Map

 Project objective

The key ideas motivating this project are that: 1) precise control of the properties of porous systems can be obtained by exploiting bacteria and their fantastic abilities; 2) conversely, porous media (large surface to volume ratios, complex structures) could be a major part of bacterial synthetic biology, as a scaffold for growing large quantities of microorganisms in controlled bioreactors.

The main scientific obstacle to precise control of such processes is the lack of understanding of biophysical mechanisms in complex porous structures, even in the case of single-strain biofilms. The central hypothesis of this project is that a better fundamental understanding of biofilm biomechanics and physical ecology will yield a novel theoretical basis for engineering and control.

The first scientific objective is thus to gain insight into how fluid flow, transport phenomena and biofilms interact within connected multiscale heterogeneous structures - a major scientific challenge with wide-ranging implications. To this end, we will combine microfluidic and 3D printed micro-bioreactor experiments; fluorescence and X-ray imaging; high performance computing blending CFD, individual-based models and pore network approaches.

The second scientific objective is to create the primary building blocks toward a control theory of bacteria in porous media and innovative designs of microbial bioreactors. Building upon the previous objective, we first aim to extract from the complexity of biological responses the most universal engineering principles applying to such systems. We will then design a novel porous micro-bioreactor to demonstrate how the permeability and solute residence times can be controlled in a dynamic, reversible and stable way - an initial step toward controlling reaction rates.

We envision that this will unlock a new generation of biotechnologies and novel bioreactor designs enabling translation from proof-of-concept synthetic microbiology to industrial processes.

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The information about "BEBOP" are provided by the European Opendata Portal: CORDIS opendata.

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