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SPOT SIGNED

SPOT - Synthesis of Pretargeted Oncology Theranostics

Total Cost €

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EC-Contrib. €

0

Partnership

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 SPOT project word cloud

Explore the words cloud of the SPOT project. It provides you a very rough idea of what is the project "SPOT" about.

subsequently    pancreatic    whereby    nps    adenocarcinoma    chances    trans    pdca    ab    delivering    imaging    lactic    azide    drug    sulfide    reaction    tissue    ductal    moieties    cyclooctene    exclusive    np    overcome    extremely    shielding    pretargeted    acid    immunological    generation    injected    attached    encapsulated    ratio    outcome    chemotherapeutic    probes    electrospraying    fall    deep    fragments    nanoparticle    docetaxel    zone    treatment    antibodies    gemcitabine    diagnosis    carriers    click    bioorthogonal    healthy    alginate    action    dbco    surface    penetration    animal    additionally    clickable    opponent    poly    accumulation    visualization    ligands    gaining    benefits    hyaluronic    contrast    vivo    tested    conjugated    dibenzocyclooctyne    active    spot    ideal    positive    drawbacks    tumor    preforming    pdac    size    small    intact    noise    clearance    tco    silver    lost    undergo    tetrazine    functionalized    capacities    poor    site    model    cancer    xenografts    prognosis    cycloaddition    multivalent    groups   

Project "SPOT" data sheet

The following table provides information about the project.

Coordinator
UNIVERSIDAD COMPLUTENSE DE MADRID 

Organization address
address: AVENIDA DE SENECA 2
city: MADRID
postcode: 28040
website: http://www.ucm.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 160˙932 €
 EC max contribution 160˙932 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-04-01   to  2022-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSIDAD COMPLUTENSE DE MADRID ES (MADRID) coordinator 160˙932.00

Map

 Project objective

To overcome size-related drawbacks of intact antibodies (Ab) for active tumor targeting, small but multivalent Ab-fragments, which fall in the “ideal tumor targeting zone”, are gaining increasing interest. However, the achieved benefits of Ab-fragments are lost when conjugated to imaging probes or drug carriers. Therefore, the SPOT action is going to focus on the generation of small Ab-fragments with highly specific targeting capacities and deep tissue penetration that are able to subsequently undergo a bioorthogonal click reaction at the tumor site. As cancer model, pancreatic ductal adenocarcinoma (PDAC), which currently still has an extremely poor prognosis, is going to be targeted. Two different click reaction will be evaluated: The cycloaddition between tetrazine and trans-cyclooctene (TCO) as well as azide and dibenzocyclooctyne (DBCO), whereby the Ab-fragments are functionalized with the TCO and DBCO groups. The opponent moieties are attached to alginate and hyaluronic acid-based ligands, which are subsequently introduced to the nanoparticle’s (NP) surface, additionally providing shielding from the immunological system. After the accumulation of the clickable Ab-fragments at the tumor site and their clearance from healthy tissue, the imaging or drug-delivering NPs with the opponent clickable moieties are injected, allowing for their exclusive accumulation at the pretargeted tumor site. For effective visualization of PDAC tissue, state-of-the-art silver sulfide NPs, with a high contrast-to-noise ratio and deep tissue imaging, are applied. The use of these NPs can be a significant step towards early PDCA diagnosis and therefore providing better chances for a positive treatment outcome. For the pretargeted drug-delivery approach, poly(lactic acid)-based NPs with encapsulated gemcitabine or docetaxel generated via electrospraying are going to be tested as a potential chemotherapeutic approach for PDAC, preforming small animal in vivo studies with PDAC xenografts.

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The information about "SPOT" are provided by the European Opendata Portal: CORDIS opendata.

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