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MBMsforDOC SIGNED
Model-based biomarkers for the characterization and quantification of global states of consciousness
Total Cost €
0EC-Contrib. €
0Partnership
0Views
0MBMsforDOC project word cloud
Explore the words cloud of the MBMsforDOC project. It provides you a very rough idea of what is the project "MBMsforDOC" about.
synergy
disorders
underlying
brain
neuroimaging
diagnostic
stages
contrast
computational
human
mbms
patients
integrate
ebms
consciousness
doc
mbm
categories
diagnosis
empirically
functional
sufficient
patient
precisely
acute
structural
gaps
systematic
combines
previously
naturally
extract
thing
thresholds
networks
combined
groups
utility
conscious
question
models
area
biomarkers
connectivity
theory
analyze
ebm
proposing
insights
silico
neuroscience
capacity
mechanisms
clinical
chronic
causal
studying
complement
model
biomarker
medicine
time
adjusted
basic
perturbational
simulations
interdisciplinary
prognostic
segregate
mainly
expertise
empirical
neural
fingerprinting
family
hypothesis
separate
single
data
Project "MBMsforDOC" data sheet
The following table provides information about the project.
| Coordinator |
INSTITUT DU CERVEAU ET DE LA MOELLE EPINIERE
Organization address contact info |
| Coordinator Country | France [FR] |
| Total cost | 196˙707 € |
| EC max contribution | 196˙707 € (100%) |
| Programme |
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility) |
| Code Call | H2020-MSCA-IF-2019 |
| Funding Scheme | MSCA-IF-EF-RI |
| Starting year | 2021 |
| Duration (year-month-day) | from 2021-01-03 to 2023-01-02 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | INSTITUT DU CERVEAU ET DE LA MOELLE EPINIERE | FR (PARIS) | coordinator | 196˙707.00 |
Map
Project objective
Studying the brain mechanisms behind consciousness is a major challenge for neuroscience and medicine. Yet so far, there is no such thing as a unique biomarker that can precisely define the state of consciousness of a disorders of consciousness (DOC) patient. All the biomarkers proposed so far are theory-based but empirically defined (EBM; empirical biomarkers): the thresholds that separate categories are set in a data-driven way. In this project, we propose a novel approach using model-based biomarkers (MBM). This new family of biomarkers (MBMs) will not only complement the EBMs but mainly will naturally address the knowledge gaps associated with the understanding of the underlying causal mechanisms behind the different states of consciousness. The modelling of the structural and functional connectivity will be combined with novel, systematic perturbational approaches that can provide new insights into the human brain’s ability to integrate and segregate information over time. In particular, with this approach we will address the hypothesis that MBMs provide functional fingerprinting of conscious states and insights into the underlying necessary and sufficient brain networks as well as their neural mechanisms. To address the development of these biomarkers, we propose a highly interdisciplinary project that combines basic and clinical neuroscience with whole-brain computational modelling proposing a synergy between two groups with large expertise in each area to address a common question We will develop computational whole-brain models based on single-patient neuroimaging data. We will extract MBM from the adjusted model parameters and from in-silico simulations. We will test the utility of these biomarkers for the diagnosis of patients with chronic DOC. Then, we will contrast the MBM with a set of previously developed EBM. Finally, we will analyze the diagnostic and prognostic capacity of these biomarkers in DOC patients in both chronic and acute stages.
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The information about "MBMSFORDOC" are provided by the European Opendata Portal: CORDIS opendata.
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No valid XML
lastchecktime (2024-04-20 5:57:58) correctly updated