EARLYNUTRITION
Long-term effects of early nutrition on later health
| Coordinatore | LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
Organization address
address: GESCHWISTER SCHOLL PLATZ 1 contact info |
| Nazionalità Coordinatore | Germany [DE] |
| Sito del progetto | http://www.project-earlynutrition.eu/ |
| Totale costo | 11˙558˙996 € |
| EC contributo | 8˙962˙771 € |
| Programma | FP7-KBBE
Specific Programme "Cooperation": Food, Agriculture and Biotechnology |
| Code Call | FP7-KBBE-2011-5 |
| Funding Scheme | CP-IP |
| Anno di inizio | 2012 |
| Periodo (anno-mese-giorno) | 2012-02-01 - 2017-01-31 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
Organization address
address: GESCHWISTER SCHOLL PLATZ 1 contact info |
DE (MUENCHEN) | coordinator | 2˙890˙610.21 |
| 2 |
KING'S COLLEGE LONDON
Organization address
address: Strand contact info |
UK (LONDON) | participant | 1˙097˙153.00 |
| 3 |
UNIVERSITY OF SOUTHAMPTON
Organization address
address: Highfield contact info |
UK (SOUTHAMPTON) | participant | 977˙264.00 |
| 4 |
UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN
Organization address
address: BELFIELD contact info |
IE (DUBLIN) | participant | 459˙720.00 |
| 5 |
Medizinische Universitaet Graz
Organization address
address: AUENBRUGGERPLATZ 2 contact info |
AT (GRAZ) | participant | 388˙200.00 |
| 6 |
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
Organization address
address: The Old Schools, Trinity Lane contact info |
UK (CAMBRIDGE) | participant | 284˙100.00 |
| 7 |
ACADEMISCH ZIEKENHUIS LEIDEN
Organization address
address: Albinusdreef 2 contact info |
NL (LEIDEN) | participant | 252˙120.00 |
| 8 |
MEDSCINET UK LTD
Organization address
address: WESTMINSTER BRIDGE ROAD ST THOMAS contact info |
UK (LONDON) | participant | 234˙579.00 |
| 9 | KOBENHAVNS UNIVERSITET | DK | participant | 223˙698.74 |
| 10 |
STICHTING VU-VUMC
Organization address
address: DE BOELELAAN 1105 contact info |
NL (AMSTERDAM) | participant | 218˙642.00 |
| 11 |
UNIVERSIDAD DE GRANADA
Organization address
address: CUESTA DEL HOSPICIO SN contact info |
ES (GRANADA) | participant | 202˙140.00 |
| 12 |
BIOLUTION GMBH
Organization address
address: Karl-Farkas-Gasse 22 contact info |
AT (WIEN) | participant | 190˙016.80 |
| 13 |
STATENS SERUM INSTITUT
Organization address
address: ARTILLERIVEJ 5 contact info |
DK (KOBENHAVN S) | participant | 161˙400.00 |
| 14 |
UNIVERSIDAD DE MURCIA
Organization address
address: AVENIDA TENIENTE FLOMESTA S/N - EDIFICIO CONVALECENCIA contact info |
ES (MURCIA) | participant | 157˙098.00 |
| 15 |
NASJONALT FOLKEHELSEINSTITUTT
Organization address
address: Lovisenberggata 8 contact info |
NO (OSLO) | participant | 150˙115.00 |
| 16 |
UNIVERSITAT ROVIRA I VIRGILI
Organization address
address: CARRER DE ESCORXADOR contact info |
ES (TARRAGONA) | participant | 147˙240.00 |
| 17 |
ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
Organization address
address: 's Gravendijkwal 230 contact info |
NL (ROTTERDAM) | participant | 139˙800.00 |
| 18 |
UNIVERSITY COLLEGE CORK, NATIONAL UNIVERSITY OF IRELAND, CORK
Organization address
address: Western Road contact info |
IE (CORK) | participant | 131˙688.00 |
| 19 |
INSTYTUT POMNIK CENTRUM ZDROWIA DZIECKA
Organization address
address: Aleja Dzieci Polskich 20 contact info |
PL (WARSZAWA) | participant | 118˙380.00 |
| 20 |
UNIVERSITA DEGLI STUDI DI MILANO
Organization address
address: Via Festa Del Perdono 7 contact info |
IT (MILANO) | participant | 111˙060.00 |
| 21 |
WARSZAWSKI UNIWERSYTET MEDYCZNY
Organization address
address: UL. ZWIRKI I WIGURY 61 contact info |
PL (WARSZAWA) | participant | 103˙300.00 |
| 22 |
ServiceXS BV
Organization address
address: Plesmanlaan 1.d contact info |
NL (Leiden) | participant | 98˙400.00 |
| 23 |
CENTRE HOSPITALIER CHRETIEN ASBL
Organization address
address: RUE DE HESBAYE 75 contact info |
BE (LIEGE) | participant | 74˙315.78 |
| 24 |
NIZO FOOD RESEARCH BV
Organization address
address: KERNHEMSEWEG 2 contact info |
NL (EDE GLD) | participant | 63˙806.25 |
| 25 |
THE UNIVERSITY OF NOTTINGHAM
Organization address
address: University Park contact info |
UK (NOTTINGHAM) | participant | 59˙520.00 |
| 26 |
NATIONAL AND KAPODISTRIAN UNIVERSITY OF ATHENS
Organization address
address: CHRISTOU LADA 6 contact info |
EL (ATHENS) | participant | 25˙680.00 |
| 27 |
UNIVERSITE LIBRE DE BRUXELLES
Organization address
address: Avenue Franklin Roosevelt 50 contact info |
BE (BRUXELLES) | participant | 2˙724.22 |
| 28 |
ABBOTT LABORATORIES SA
Organization address
address: AVENIDA DE BURGOS 91 contact info |
ES (MADRIDE) | participant | 0.00 |
| 29 |
BENEO GMBH
Organization address
address: MAXIMILIANSTRAAT 10 contact info |
DE (MANNHEIM) | participant | 0.00 |
| 30 |
CASE WESTERN RESERVE UNIVERSITY CORPORATION - CWRU
Organization address
address: EUCLIDE AVENUE 10900 contact info |
US (CLEVELAND) | participant | 0.00 |
| 31 |
DANONE RESEARCH BV
Organization address
address: Bosrandweg 20 contact info |
NL (UTRECHT) | participant | 0.00 |
| 32 |
HARVARD PILGRIM HEALTH CARE INC CORP
Organization address
address: WORCESTER STREET 93 contact info |
US (WELLESLEY MA) | participant | 0.00 |
| 33 |
MURDOCH CHILDRENS RESEARCH INSTITUTE
Organization address
address: FLEMINGTON ROAD RCH contact info |
AU (PARKVILLE) | participant | 0.00 |
| 34 |
TELETHON INSTITUTE FOR CHILD HEALTH RESEARCH
Organization address
address: ROBERTS ROAD 100 contact info |
AU (SUBIACO) | participant | 0.00 |
| 35 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Organization address
address: "FRANKLIN STREET 1111, 12 FLOOR" contact info |
US (OAKLAND CA) | participant | 0.00 |
| 36 |
THE UNIVERSITY OF ADELAIDE
Organization address
address: NORTH TERRACE contact info |
AU (ADELAIDE) | participant | 0.00 |
| 37 |
THE UNIVERSITY OF TEXAS SYSTEM
Organization address
address: COLORADO STREET 601 contact info |
US (AUSTIN) | participant | 0.00 |
| 38 |
VERENIGING VOOR CHRISTELIJK HOGER ONDERWIJS WETENSCHAPPELIJK ONDERZOEK EN PATIENTENZORG
Organization address
address: De Boelelaan 1105 contact info |
NL (AMSTERDAM) | participant | 0.00 |
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Obiettivo del progetto (Objective)
'Nutrition during early development has an important impact on later health, particularly through greater obesity risk, as demonstrated by FP6 EARNEST. EarlyNutrition explores the current key hypotheses on likely causes and pathways to prevention of early life origins of obesity (specifically adiposity) and associated disorders. We bring extraordinary expertise and study populations of 470,000 individuals to investigate: • The fuel mediated in utero hypothesis • The accelerated postnatal weight gain hypothesis • The mismatch hypothesis. Scientific and technical expertise in placental biology, epigenetics and metabolomics will provide understanding at the cellular and molecular level, and refined strategies for intervention in pregnancy and early post natal life to prevent obesity. Using existing cohort studies, ongoing and novel intervention studies and a basic science programme, we will provide the scientific foundations for evidence based recommendations for optimal EarlyNutrition that incorporate long-term health outcomes, focusing on 4 Target Groups: women before pregnancy; pregnant women; infants (incl. breastfeeding); young children. Evidence is produced from animal and placental studies (Theme 1; T1), prospective cohort studies (T2), and randomised controlled trials in pregnant women and infants (T3). T4 covers scientific strategic integration, recommendation development and dissemination, including systematic reviews and behaviour change approaches. A strong multi-disciplinary team of international leaders in the field including collaborators from USA and Australia achieves balance and complementarity. The project’s impact comprises definitive evidence on early nutrition effects on health, enhanced EU and global policies, major economic benefits through obesity prevention and value-added nutritional products, and practical recommendations on optimal nutrition in Target Groups. Wide dissemination will be achieved through active engagement with stakeholders.'
Introduzione (Teaser)
The adage 'we are what we eat' applies to our long-term health and well-being. Predisposition to obesity and metabolic disorders can be linked to diet and lifestyle right from our time in the womb.
Descrizione progetto (Article)
The current obesity epidemic is clearly only in part of genetic origin, but unfavourable changes in environment and lifestyle that cause obesity and associated disorders remain elusive. Nutrition during early years has an important impact on later health, and might correlate with obesity risk.
An ongoing 5-year EU-funded project, http://www.project-earlynutrition.eu/ (EARLYNUTRITION) (Long-term effects of early nutrition on later health), is investigating this correlation on a collection of several cohorts of 470 000 individuals. The study populations include women before pregnancy, pregnant women, infants and young children. Alongside epidemiological and interventional approaches, advanced methods of bioinformatics, epigenetics and metabolomics are providing information also at the cellular and molecular levels.
The project is analysing the mechanisms for early nutrition programming by following up on human cohorts in childhood, adolescence and adulthood as one of the focus areas. For instance, new evidence reveals that greater childhood adiposity is associated with maternal vitamin D insufficiency and with low levels of activity in children.
EARLYNUTRITION linked maternal dietary glycaemic load in early (but not late) pregnancy with childhood adiposity. Greater abdominal circumference gain during early infancy was found to correlate with higher childhood blood pressure. Currently analysed data from major cohorts will establish the long-term effects of maternal pregnancy weight gain, body composition and smoking on offspring adiposity/co-morbidities.
Data from animal models and placental samples are also being collected and analysed. Thus, in vitro studies in perfused placentas are providing insights into biological mechanisms of fatty acid transport. A difference in target gene expression in human and animal placentas from obese compared to lean mothers is analysed using a microarray approach. In rodents, maternal obesity is associated with abnormal glucose homeostasis. New data suggests maternal dietary and exercise interventions can favourably influence the phenotype of their offspring.
Current recommendations for pregnant and particularly obese women and for young children do not take into account the long-term health consequences of nutrition. EARLYNUTRITION is reviewing the evidence to optimise recommendations on nutrition before and during pregnancy, the breastfeeding period and childhood, with special reference to later health development. Current recommendations and latest research findings are furthermore translated into practical application by the http://www.early-nutrition.org/ENeA (Early Nutrition eAcademy), an e-learning platform conceptualized for the continuing medical education of international health care professionals. State of the art research in the field and project achievements will be presented at the second EarlyNutrition conference in October 2016, http://munich2016.project-earlynutrition.eu/ (The Power of Programming 2016).